Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Ann M Saunders"'
Autor:
Lei Yu, Michael W Lutz, Robert S Wilson, Daniel K Burns, Allen D Roses, Ann M Saunders, Jingyun Yang, Chris Gaiteri, Philip L De Jager, Lisa L Barnes, David A Bennett
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180356 (2017)
Patterns of linkage between the ε4 allele of Apolipoprotein E (APOE) and '523 poly-T alleles in the adjacent gene, TOMM40, differ between Caucasian and African Americans. The extent to which this difference affects the risk of Alzheimer's disease (A
Externí odkaz:
https://doaj.org/article/9346f1093cb546f99d3b8a84822231a2
Autor:
Donald M Lyall, Natalie A Royle, Sarah E Harris, Mark E Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W Lutz, Ann M Saunders, Allen D Roses, Maria C del Valdés Hernández, John M Starr, David J Porteous, Joanna M Wardlaw, Ian J Deary
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80513 (2013)
The APOE ε and TOMM40 rs10524523 ('523') variable length poly-T repeat gene loci have been significantly and independently associated with Alzheimer's disease (AD) related phenotypes such as age of clinical onset. Hippocampal atrophy has been signif
Externí odkaz:
https://doaj.org/article/4b656b486d5a421890436bac0f1814b1
Autor:
Colton Linnertz, Ann M Saunders, Michael W Lutz, Donna M Crenshaw, Iris Grossman, Daniel K Burns, Keith E Whitfield, Michael A Hauser, Jeanette J McCarthy, Megan Ulmer, Rand Allingham, Kathleen A Welsh-Bohmer, Allen D Roses, Ornit Chiba-Falek
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30994 (2012)
We previously discovered that a polymorphic, deoxythymidine-homopolymer (poly-T, rs10524523) in intron 6 of the TOMM40 gene is associated with age-of-onset of Alzheimer's disease and with cognitive performance in elderly. Three allele groups were def
Externí odkaz:
https://doaj.org/article/f942e05d472a4d749d9caeb46a486e20
Autor:
Carl Chiang, Jacquelynn Copeland, Vanessa Raymont, Peter Connelly, Reto Kressig, Guy G. Potter, Daniel K. Burns, Stephen Pearson, Manish Saxena, Ann M. Saunders, Debra Fleischman, DeRen Huang, Thomas Leyhe, Gabriel Leger, Gigi Lefebvre, Mardik Donikyan, Natalie Denburg, Alex Knopman, Nancy Voight, James Burke, Philip Moore, James R. Burke, Margaret Newson, Stephen Haneline, Adam J. Schwarz, George Demakis, Joseph Butchart, Robert Mitchell, Mark Leibowitz, Michael Woodward, Robert Alexander, Concetta Forchetti, Emiliangelo Ratti, Andreas U. Monsch, Lon S. Schneider, Aaron Ritter, Joscelyn Agron-Figueroa, Fraser Inglis, Craig Curtis, Judith Neugroschl, Geraint Price, Mark Brody, Clark Johnson, Clive Ballard, Stephen Thein, Meredith Culp, Kristine Yaffe, Ahad Sabet, Walter Braude, Gregory Kirk, David Krefetz, Rupert Noad, Omid Omidvar, John Sass, Brenda L. Plassman, James Bergthold, Arne Klostermann, Haydn Till, Aaron Ellenbogen, Patrick Harrigan, Heinz-Peter Herbst, Joseph Kass, Lorna Wallace, Jennifer Robinson, Elliot Henderson, Felicia Goldstein, Christopher McWilliam, R. Clarnette, Jerry Halsten, Dan Rujescu, Silvana Micallef, Nestor Galvez-Jimenez, Jeffrey Ross, Dag Aarsland, Hugh Miller, Theresa Campbell, Jingtao Wu, Allan Levey, Liebhild Stratmann, Rosalyn Lai, Agnes Flöel, Richard Shingleton, Steve Higham, Pierre N. Tariot, Esteban Olivera, Sandra Carusa, Amanda Olley, Ricky Mofsen, Kathryn Goozee, Kara Lyons, Richard J. Brown, Marwan N. Sabbagh, Virginia De Sanctis, Jerome Goldstein, Hamid R. Sohrabi, Lefkos T. Middleton, Eugen Schlegel, Donna Munic-Miller, Sylvia Robinson, David Watson, Oda Ackermann, Ralph Votolato, Peter Bailey, Paul Massman, Daniel Gruener, Robert Perneczky, Frederick Schaerf, Craig W. Ritchie, Scott Losk, Christina Zimmerman, Mario Parra, Jill Crusey, Edward Zamrini, Christine Belden, Thomas Arnold, Alexander White, Linda Rice, Elizabeth Coulthard, Jane Martin, Anne Koplin, Rebecca Evans, Janet O'Neil, Oliver Peters, Raj Shah, Marshall Nash, Ronald Bradley, Kathleen A. Welsh-Bohmer, Howard Hassman, Scott Barton, Robert Cohen, Robert Stephenson, Jacobo Mintzer, Michael W. Lutz, Wendy Bond, Rachelle S. Doody, Ronald Hofner, Laura Samson
Publikováno v:
The Lancet Neurology. 20:537-547
Background: The identification of people at risk of cognitive impairment is essential for improving recruitment in secondary prevention trials of Alzheimer's disease. We aimed to test and qualify a biomarker risk assignment algorithm (BRAA) to identi
Autor:
David P. Yarnall, Stephen Haneline, Brenda L. Plassman, Carl Chiang, Kathleen A. Welsh-Bohmer, Grant Runyan, Stephen Brannan, Janet O'Neil, Patrick Harrigan, Craig Metz, Ann M. Saunders, Eric Lai, Daniel K. Burns, Meredith Culp, Scott S. Sundseth, Sridevi Ponduru, Michael W. Lutz, Deborah Yarbrough
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Introduction Alzheimer's disease (AD) is a continuum with neuropathologies manifesting years before clinical symptoms; thus, AD research is attempting to identify more disease-modifying approaches to test treatments administered before full disease e
Autor:
Stephen Haneline, Elaine R. Peskind, Lon S. Schneider, David A. Bennett, Janet O'Neil, Mary Sano, Robert Alexander, Meredith Culp, Ryan Walter, Sylvia Maresca, Martin R. Farlow, Murray A. Raskind, Daniel K. Burns, Ann M. Saunders, Yaakov Stern, Kathleen A. Welsh-Bohmer, Carl Chiang
Background The onset of mild cognitive impairment (MCI) is an essential outcome in Alzheimer’s disease (AD) prevention trials and a compelling milestone for clinically meaningful change. Determining MCI, however, may be variable and subject to disa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ac30343eb29afaae400fa78f42be206
https://doi.org/10.21203/rs.3.rs-806031/v1
https://doi.org/10.21203/rs.3.rs-806031/v1
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience, Vol 15 (2021)
Alzheimer’s disease is a quintessential ‘unmet medical need’, accounting for ∼65% of progressive cognitive impairment among the elderly, and 700,000 deaths in the United States in 2020. In 2019, the cost of caring for Alzheimer’s sufferers
Autor:
Daniel K. Burns, Scott Marshall, Ann M. Saunders, Emiliangelo Ratti, Sarah N. Statt, Eric Lai, Meredith Culp, Tom Swanson, Bernard F. Andruss, Scott S. Sundseth, Carl Chiang, Tobi Guennel, Bradley Hall, Craig A. Metz, Gary J. Latham, Michael W. Lutz, Stephen Haneline, Robert Alexander, David Yarnall
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Julia, Pytte, Loren L, Flynn, Ryan S, Anderton, Frank L, Mastaglia, Frances, Theunissen, Ian, James, Abigail, Pfaff, Sulev, Koks, Ann M, Saunders, Richard, Bedlack, Daniel K, Burns, Michael W, Lutz, Nailah, Siddique, Teepu, Siddique, Allen D, Roses, P Anthony, Akkari
Publikováno v:
Neurology: Genetics
Objective To test the hypothesis that rs573116164 will have disease-modifying effects in patients with superoxide dismutase 1 (SOD1) familial amyotrophic lateral sclerosis (fALS), we characterized rs573116164 within a cohort of 190 patients with fALS
Autor:
Shuhong Luo, Isaac Ng, Allen D. Roses, Sonal Gagrani, Lefko Charlambous, Daniel L. Rock, Mirta Mihovilovic, Ann M. Saunders, W. Kirby Gottschalk, Kahli Zeitlow
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863:2973-2986
A variable-length poly-T variant in intron 6 of the TOMM40 gene, rs10524523, is associated with risk and age-of-onset of sporadic (late-onset) Alzheimer's disease. In Caucasians, the three predominant alleles at this locus are Short (S), Long (L) or