Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ann M Ranger"'
Autor:
Agnes Gardet, Wei C Chou, Taylor L Reynolds, Diana B Velez, Kai Fu, Julia M Czerkowicz, Jeffrey Bajko, Ann M Ranger, Normand Allaire, Hannah M Kerns, Sarah Ryan, Holly M Legault, Robert W Dunstan, Robert Lafyatis, Matvey Lukashev, Joanne L Viney, Jeffrey L Browning, Dania Rabah
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164423 (2016)
Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelera
Externí odkaz:
https://doaj.org/article/de2edfb8f586497f81cac95be2baa6e6
Autor:
J. Marie Hardwick, Iva Ivanovska, Ying Bei Chen, Valina L. Dawson, So Young Seo, Suk Jin Hong, Yihru Fannjiang, Stanley J. Korsmeyer, David S. Bellows, Ann M. Ranger
Publikováno v:
Journal of Biological Chemistry. 279:42240-42249
The mammalian BAD protein belongs to the BH3-only subgroup of the BCL-2 family. In contrast to its known pro-apoptotic function, we found that endogenous and overexpressed BAD(L) can inhibit cell death in neurons and other cell types. Several mechani
Publikováno v:
Nature Genetics. 28:113-118
Cell death is critical for the development and orderly maintenance of cellular homeostasis in metazoans. Developmental genetics in model systems, including Caenorhabditis elegans and Drosophila melanogaster, have helped to identify and order the comp
Autor:
Michael J. Grusby, Fabienne Charles de la Brousse, Ann M. Ranger, Tim Hoey, Martin R. Hodge, H. Scott Baldwin, Laurie H. Glimcher, Ellen M. Gravallese, Craig S. Mickanin
Publikováno v:
Nature. 392:186-190
Nuclear factor of activated T cells (NF-AT) is the name of a family of four related transcription factors that may be needed for cytokine gene expression in activated lymphocytes1,2,3,4. Here we report that mice with a targeted disruption of the NF-A
Autor:
Mercy Prabhu Das, Vijay K. Kuchroo, Julia A. Brown, Raymond A. Sobel, Nasrin Nabavi, Ann M. Ranger, Laurie H. Glimcher, Howard L. Weiner, Scott S. Zamvil
Publikováno v:
Cell. 80:707-718
CD4 T helper precursor cells mature along two alternative pathways, Th1 and Th2. Here we show that these pathways are differentially activated by two costimulatory molecules, B7-1 and B7-2. Using anti-B7 antibodies, this developmental step was manipu
Autor:
Stanley J. Korsmeyer, Ann M. Ranger, Sandeep Robert Datta, Michael E. Greenberg, Michelle M. Le Beau, Hisashi Harada, Jeffery L. Kutok, Jiping Zha, Nika N. Danial, Andrew P. Gilmore
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(16)
The proapoptotic activity of the “BH3-only” molecule BAD can be differentially regulated by survival factor signaling. Bad -deficient mice lacking both BAD long and BAD short proteins proved viable, and most cell types appeared to develop normall
Autor:
Colette F. Gramm, Chen-Yu Zhang, Luca Scorrano, Nika N. Danial, Ann M. Ranger, Steven P. Gygi, Bradford B. Lowell, Michael E. Greenberg, Stefan Krauss, Stanley J. Korsmeyer, Lawrence J. Licklider, Sandeep Robert Datta
Publikováno v:
Nature. 424(6951)
Glycolysis and apoptosis are considered major but independent pathways that are critical for cell survival1,2,3,4. The activity of BAD, a pro-apoptotic BCL-2 family member, is regulated by phosphorylation in response to growth/survival factors5,6,7,8
Autor:
Pieter Dikkes, Christopher W. Cowan, Michael E. Greenberg, Stanley J. Korsmeyer, Michael Z. Lin, Yong Chao Ma, Ann M. Ranger, Sandeep Robert Datta, James Fitzhugh Sturgill
Publikováno v:
Developmental cell. 3(5)
Growth factor suppression of apoptosis correlates with the phosphorylation and inactivation of multiple proapoptotic proteins, including the BCL-2 family member BAD. However, the physiological events required for growth factors to block cell death ar
Autor:
Ann M. Ranger, Stanley J. Korsmeyer, Charles H. Streuli, Pengbo Wang, Michael J. O'Hare, Andrew P. Gilmore, Anthony J. Valentijn, A. E. Wakeling, Nigel J Bundred
Publikováno v:
The Journal of biological chemistry. 277(31)
Novel cancer chemotherapeutics are required to induce apoptosis by activating pro-apoptotic proteins. Both epidermal growth factor (EGF) and insulin-like growth factor (IGF) provide potent survival stimuli in many epithelia, and activation of their r
Autor:
Ann M. Ranger, Ellen M. Gravallese, Tamiyo Kon, Jinxi Wang, Hyunsu Bae, Melvin J. Glimcher, Laurie H. Glimcher, Louis C. Gerstenfeld
Publikováno v:
The Journal of Experimental Medicine
Nuclear factor of activated T cells (NFAT) transcription factors regulate gene expression in lymphocytes and control cardiac valve formation. Here, we report that NFATp regulates chondrogenesis in the adult animal. In mice lacking NFATp, resident cel