Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Ann Louw"'
Publikováno v:
Journal of Photochemistry and Photobiology, Vol 22, Iss , Pp 100242- (2024)
Exposure to Ultraviolet B (UVB) radiation can trigger a diverse array of biological responses that have the potential to contribute to the onset of skin cancer. Natural compounds, such as tea polyphenols, have been shown to protect against UVB-induce
Externí odkaz:
https://doaj.org/article/f6a4413dba2745e58e3cf8427659efa5
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Breast cancer is the most diagnosed type of cancer amongst women in economically developing countries and globally. Most breast cancers express estrogen receptor alpha (ERα) and are categorized as positive (ER+) breast cancer. Endocrine therapies su
Externí odkaz:
https://doaj.org/article/f49e35afb7394876bfa76c148999a12f
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Synergistic drug combinations are not only popular in antibiotic, anti-microbial, immune disease (i.e., AIDS) and viral infection studies, but has also gained traction in the field of cancer research as a multi-targeted approach. It has the potential
Externí odkaz:
https://doaj.org/article/3937824efb204e5ab2f02460677aab52
Publikováno v:
Cells, Vol 11, Iss 14, p 2163 (2022)
Acute phase proteins (APPs), such as plasminogen activator inhibitor-1 (PAI-1), serum amyloid A (SAA), and C-reactive protein (CRP), are elevated in type-2 diabetes (T2D) and are routinely used as biomarkers for this disease. These APPs are regulated
Externí odkaz:
https://doaj.org/article/1ccf1e9b8f5f48ac9a86c02a0a103735
Publikováno v:
Cells, Vol 10, Iss 10, p 2529 (2021)
For over 70 years, the unique anti-inflammatory properties of glucocorticoids (GCs), which mediate their effects via the ligand-activated transcription factor, the glucocorticoid receptor alpha (GRα), have allowed for the use of these steroid hormon
Externí odkaz:
https://doaj.org/article/e44ab430fb31418aa939be0bc355f008
Autor:
Ann Louw
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Pharmacologically, glucocorticoids, which mediate their effects via the glucocorticoid receptor (GR), are a most effective therapy for inflammatory diseases despite the fact that chronic use causes side-effects and acquired GC resistance. The design
Externí odkaz:
https://doaj.org/article/c758bb5ea6714c16870f88206979644e
Publikováno v:
Endocrine Connections, Vol 7, Iss 12, Pp R328-R349 (2018)
The development of resistance to glucocorticoids (GCs) in therapeutic regimens poses a major threat. Generally, GC resistance is congenital or acquired over time as a result of disease progression, prolonged GC treatment or, in some cases, both. Esse
Externí odkaz:
https://doaj.org/article/d49383a35264486ca84f60be54cafcc7
Chemoprevention of LA7-Induced Mammary Tumor Growth by SM6Met, a Well-Characterized Cyclopia Extract
Autor:
Omolola R. Oyenihi, Annadie Krygsman, Nicolette Verhoog, Dalene de Beer, Michael J. Saayman, Thys M. Mouton, Ann Louw
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Breast cancer (BC) is the leading cause of cancer-related deaths in women. Chemoprevention of BC by using plant extracts is gaining attention. SM6Met, a well-characterized extract of Cyclopia subternata with reported selective estrogen receptor subty
Externí odkaz:
https://doaj.org/article/d3c2c745a36146d2a2233251c5b7da3d
Autor:
Nicolette Verhoog, Fatima Allie-Reid, Wim Vanden Berghe, Carine Smith, Guy Haegeman, Janet Hapgood, Ann Louw
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110702 (2014)
Corticosteroid-binding globulin (CBG), a negative acute phase protein produced primarily in the liver, is responsible for the transport of glucocorticoids (GCs). It also modulates the bioavailability of GCs, as only free or unbound steroids are biolo
Externí odkaz:
https://doaj.org/article/0ae8bc14c40840db8f921502d402b6c9
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64831 (2013)
Glucocorticoid receptor (GR) levels vary between tissues and individuals and are altered by physiological and pharmacological effectors. However, the effects and implications of differences in GR concentration have not been fully elucidated. Using th
Externí odkaz:
https://doaj.org/article/e842dc4185cd41e1a63c37b59068e326