Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Ann L. Sharpley"'
Autor:
Alexandra C. Pike, Ann L. Sharpley, Rebecca J. Park, Philip J. Cowen, Michael Browning, Erdem Pulcu
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Eating disorders are characterised by altered eating patterns alongside overvaluation of body weight or shape, and have relatively low rates of successful treatment and recovery. Notably, cognitive inflexibility has been implicated in both t
Externí odkaz:
https://doaj.org/article/2d8491c0934244d3b1d253bdd2490fc6
Autor:
Beata R. Godlewska, Philip J. Cowen, Stephen R. Williams, Ana Jorge Goncalves, Brian Angus, Uzay E. Emir, Chi Chen, Ann L. Sharpley, William T. Clarke, Monique Andersson
Publikováno v:
Psychopharmacology
Rationale Chronic fatigue syndrome (CFS) is a common and burdensome illness with a poorly understood pathophysiology, though many of the characteristic symptoms are likely to be of brain origin. The use of high-field proton magnetic resonance spectro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc672e990b4db1513ff0988c94544653
https://doi.org/10.1007/s00213-021-05986-6
https://doi.org/10.1007/s00213-021-05986-6
Autor:
Beata R. Godlewska, Orla Macdonald, Milensu Shanyinde, Ann L. Sharpley, Adele A Holder, Philip J. Cowen, Clare Williams, Nisha Singh
Publikováno v:
Psychopharmacology
Rationale Lithium is an effective prophylactic and anti-manic treatment in bipolar disorder; however, its use is declining through perceived poor tolerance and toxicity. Lithium inhibits inositol monophosphatase (IMPase), a probable key therapeutic m
Autor:
J. C. Gibson, Hasanen Al-Taiar, Alexis Economou, Jennifer M Rendell, D J Quested, F Ahmad, J Lawson, Ann L. Sharpley, John R. Geddes, J. H. Cordey, Merryn Voysey, A. Lennox, F De Crescenzo
Publikováno v:
Bipolar disordersREFERENCES. 23(2)
Objectives: Current options for treating emergent episodes of hypomania and mania in bipolar disorder are limited. Our objective was to compare the effectiveness and safety of add‐on melatonin in hypomania or mania over three weeks as a well‐tole
Publikováno v:
Psychological Medicine
BackgroundThe possible role of glutamate in the pathophysiology and treatment of depression is of intense current interest. Proton magnetic resonance spectroscopy (MRS) enables the detection of glutamate in the living human brain and meta-analyses of
Publikováno v:
Sleep Medicine Reviews. 33:58-69
Sleep disruptions represent a core feature of bipolar disorders and have been widely studied through the use of actigraphy, which is an objective measure of motor activity and sleep. Finding objective outcomes, which reliably measure sleep in bipolar
Autor:
Beata R. Godlewska, Philip J. Cowen, Clare Williams, Richard G. Compton, Ann L. Sharpley, Kamonwad Ngamchuea, Christopher Batchelor-McAuley
Background Glutathione (GSH) is an important cellular antioxidant and its levels are decreased in some studies of bipolar patients. Saliva provides a simple and feasible means of measuring GSH but has not yet been applied to the study of bipolar diso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59c7b2af31e01c926dbc33b08eca9b0
https://ora.ox.ac.uk/objects/uuid:86143139-6d47-4d60-bc6b-135d09d26832
https://ora.ox.ac.uk/objects/uuid:86143139-6d47-4d60-bc6b-135d09d26832
Autor:
Ann L. Sharpley, Catherine J. Harmer, Eleanor Barnes, Beata R. Godlewska, Philip J. Cowen, C M Cooper
Publikováno v:
Psychological Medicine
BackgroundTreatment of medical patients with the inflammatory cytokine, interferon-α (IFN-α), is frequently associated with the development of clinical depressive symptomatology. Several important biological correlates of the effect of IFN-α on mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e56df2f7b5ba72b592dc5060c877c0
https://ora.ox.ac.uk/objects/uuid:e6ce8da0-2cf7-4046-9e73-0c8c36e9cfd9
https://ora.ox.ac.uk/objects/uuid:e6ce8da0-2cf7-4046-9e73-0c8c36e9cfd9
Brain glutamate in anorexia nervosa: A magnetic resonance spectroscopy case control study at 7 Tesla
Autor:
Ann L. Sharpley, Philip J. Cowen, Rebecca J. Park, Agnes Ayton, Alexandra C. Pike, Uzay E. Emir, Beata R. Godlewska
Publikováno v:
Psychopharmacology
Rationale Anorexia nervosa (AN) is a serious psychiatric disorder with high morbidity and mortality. There are no established pharmacological treatments and the neurobiology of the condition is poorly understood. Previous studies using magnetic reson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e0698276638149cd1a6afaf0c51eee
https://ora.ox.ac.uk/objects/uuid:7197f6c5-8f84-4c87-9c04-4a4f2b87964e
https://ora.ox.ac.uk/objects/uuid:7197f6c5-8f84-4c87-9c04-4a4f2b87964e
Publikováno v:
European Neuropsychopharmacology. 28:S66-S67
N-acetyl cysteine (NAC) is a dietary supplement and glutathione precursor which has shown benefit in the treatment of psychiatric disorders that feature prominent compulsive behaviours such as excoriation and trichotillomania [1]. Eating disorders su