Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ann L Scott"'
Autor:
Theodore P. Broten, Jill M. Erb, Mark G. Bock, Jennie B. Nerenberg, Raymond S.L. Chang, Jeffrey M. Bergman, Stacey O'Malley, Ann L. Scott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:291-294
The 4-oxospiro[benzopyran-2,4'-piperidine] ring system is contained within potent class III antiarrhythmic agents. We highlight how these agents can be chemically transformed into a new class of potent (1 nM) and selective (25-fold) alpha 1a-receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38b11e6d14be9e2854308cc1d845fe8
https://doi.org/10.1016/s0960-894x(98)00732-x
https://doi.org/10.1016/s0960-894x(98)00732-x
Autor:
Theodore P. Broten, Wayne J. Thompson, Hee Yoon Lee, Ann L. Scott, Jill M. Erb, Joel R. Huff, Terry W. Schorn, Jennie B. Nerenberg, Raymond S.L. Chang, Tsing B. Chen, James P. Guare, Stacey O'Malley, Peter M. Munson, Jeffrey M. Bergman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2467-2472
Benign prostatic hyperplasia can be managed pharmacologically with alpha-1 adrenergic receptor antagonists. Agents that demonstrate selectivity for the alpha-1a receptor subtype may offer advantages in clinical applications with respect to hypotensiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137e9f8d465460c0a6128622617a9ba7
https://doi.org/10.1016/s0960-894x(98)00446-6
https://doi.org/10.1016/s0960-894x(98)00446-6
Autor:
Theodore P. Broten, Stacey O'Malley, Jeffrey M. Bergman, Jill M. Erb, Mark G. Bock, Jennie B. Nerenberg, Ann L. Scott, Raymond S.L. Chang
Publikováno v:
ChemInform. 30
The 4-oxospiro[benzopyran-2,4′-piperidine] ring system is contained within potent class III antiarrhythmic agents. We highlight how these agents can be chemically transformed into a new class of potent ( 25-fold) α 1a -receptor subtype adrenergic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6767e799cd4b8942ae93fe410af90caa
https://doi.org/10.1002/chin.199920116
https://doi.org/10.1002/chin.199920116
Autor:
Joseph J. Lynch, Ann L. Scott, Peter K. S. Siegl, Richard T. Wiedmann, Robert B. Stein, Horacio E. Cingolani, Herbert C. Wenger
Publikováno v:
Journal of Molecular and Cellular Cardiology. 22:1025-1034
In open-chest anesthetized dogs, the time constant of isovolumic left ventricular pressure decay increased following the intravenous administration of either E4031, a class III antiarrhythmic agent which acts by K+ channel blockade, or DPI 201-106 (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7aa93010d4fb6f9e19985c99636ef62
https://doi.org/10.1016/0022-2828(90)91042-6
https://doi.org/10.1016/0022-2828(90)91042-6
Autor:
Ian Collins, Michael Rowley, Alan E. Fletcher, William B Davey, Ann L Scott, Rosemarie Marwood, Shil Patel, F. Emms, Paul D. Leeson, Theodore P. Broten, Ian C. Ragan, Smita Patel
Publikováno v:
Bioorganicmedicinal chemistry. 6(6)
3-(4-Piperidinyl)-5-arylpyrazoles, such as 1, were selective for the cloned human dopamine D4 receptor (hD4), but also showed affinity at voltage sensitive calcium, sodium and potassium ion channels. A combination of substituent changes to reduce the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f7c49406a6edd03c6b3f84a8b9eaf6
https://pubmed.ncbi.nlm.nih.gov/9681140
https://pubmed.ncbi.nlm.nih.gov/9681140
Autor:
Theodore P. Broten, Richard W. Ransom, Mark G. Bock, Carlos Forray, Jerry DiSalvo, Ann L. Scott, Raymond S.L. Chang, Michael A. Patane
Publikováno v:
Journal of medicinal chemistry. 41(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27500b55a8001580b54532ea5c2e27e
https://pubmed.ncbi.nlm.nih.gov/9548811
https://pubmed.ncbi.nlm.nih.gov/9548811
Autor:
Ian R. Cottingham, Alexander Stacey, Alan Colman, Bert Binas, Colin McKee, Angelika Schnieke, Ann L. Scott, Marian Kerr, Colin J. Wilde
Mice carrying either a deletion of the murine alpha-lactalbumin (alpha-lac) gene (null allele) or its replacement by the human alpha-lac gene (humanized allele) have been generated by gene targeting. Homozygous null females are alpha-lac-deficient, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d10d2d816fb5040906efce3594f9570
https://europepmc.org/articles/PMC42313/
https://europepmc.org/articles/PMC42313/
Autor:
David Aharony, Peter K. S. Siegl, Ann L. Scott, Raymond F. Orzechowski, W. Craig Moore, Ron C. Falcone
Publikováno v:
European journal of pharmacology. 204(2)
Leukotriene D4 (LTD4) increased the force of contraction in guinea-pig papillary muscle. A rapid (less than 1 min), transient (less than 5 min) response to LTD4 (1 microM) reached 19.3 +/- 5.4% of isoproterenol maximum. A single exposure to LTD4 resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b0ed040dc98b5bd2e4237e91b4dd77
https://pubmed.ncbi.nlm.nih.gov/1666876
https://pubmed.ncbi.nlm.nih.gov/1666876
Publikováno v:
Circulation research. 68(1)
The mechanism by which isoproterenol (ISO) prevents the prolongation of action potential duration (APD) and refractory period (RP) by the class III antiarrhythmic agent E-4031 was studied. E-4031 (1 microM) increased RP by 50% with no effect on contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2de8afa59a193dc523f50fd837b929f
https://pubmed.ncbi.nlm.nih.gov/1984874
https://pubmed.ncbi.nlm.nih.gov/1984874