Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ann Lövgren"'
Autor:
Marcus Weinguny, Gerald Klanert, Peter Eisenhut, Andreas Jonsson, Daniel Ivansson, Ann Lövgren, Nicole Borth
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1320-1329 (2020)
Chinese Hamster Ovary (CHO) cells are the working horse of the pharmaceutical industry. To obtain high producing cell clones and to satisfy regulatory requirements single cell cloning is a necessary step in cell line development. However, it is also
Externí odkaz:
https://doaj.org/article/232d6707f27a4be9977614512c8eb79d
Autor:
Marcus Weinguny, Nicole Borth, Peter Eisenhut, Nikolaus Virgolini, Daniel Ivansson, Ann Lövgren, Nicolas Marx, Andreas Jonsson, Gerald Klanert
Publikováno v:
Biotechnology and Bioengineering
Chinese hamster ovary (CHO) cells produce a large share of today's biopharmaceuticals. Still, the generation of satisfactory producer cell lines is a tedious undertaking. Recently, it was found that CHO cells, when exposed to new environmental condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a05fee2ae757bd88582abb26a1a080
https://doi.org/10.1002/bit.27493
https://doi.org/10.1002/bit.27493
Autor:
Peter Eisenhut, Andreas Jonsson, Nicole Borth, Daniel Ivansson, Gerald Klanert, Ann Lövgren, Marcus Weinguny
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1320-1329 (2020)
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1320-1329 (2020)
Graphical abstract By repeatedly selecting and pooling the most rapidly outgrowing clones during multiple single cell subcloning rounds, the time required for subcloning was reduced from 3 to 2 weeks and the cloning efficiency significantly increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aee6ce0ce8bf720036a211143d1e913
http://europepmc.org/articles/PMC7306589
http://europepmc.org/articles/PMC7306589
Autor:
Karin J Johansson, Susanne Pehrsson, Ann Lövgren, Anna Lindblom, Kenny M. Hansson, Karin Nelander
Publikováno v:
Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 30(4)
Uncontrolled bleeding due to trauma and coagulopathy is an area with high unmet medical need and high mortality rate. Treatment recommendations focus on transfusion of blood components while optimal therapy to improve coagulation remains to be establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3dbeb4207b7e341d85cbe1f9df2bb1
https://pubmed.ncbi.nlm.nih.gov/31090596
https://pubmed.ncbi.nlm.nih.gov/31090596
Publikováno v:
Haemophilia. 22:453-461
BACKGROUND Haemophilia A and B are treated with FVIII and FIX replacement therapy. Treatment may be complicated by inhibitory antibodies that require bypass therapy such as FEIBA(®) in which prothrombin (FII) is suggested to be the main active compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7fbc5810d5ca8c91d59c3cfb38afdd
https://doi.org/10.1111/hae.12861
https://doi.org/10.1111/hae.12861
Publikováno v:
Blood Coagulation & Fibrinolysis
Thrombin (FIIa) is the key enzyme in haemostasis and acts on several substrates involved in clot formation, platelet activation and feed-back regulation of its own formation. During activation of blood coagulation, FIIa is formed by proteolytic cleav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f63a57895d1e13718ab34d3d0c44d0
https://doi.org/10.1097/mbc.0000000000000289
https://doi.org/10.1097/mbc.0000000000000289
Publikováno v:
Research and Practice in Thrombosis and Haemostasis
Summary Essentials Prediction of bleeding risk in trauma patients is difficult.We evaluated a test which measures prothrombin time/ability of blood to clot.We showed the prothrombin time test reflected prothrombin concentration in blood.The test coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fbcd84d82955771b979a91928a99f9
https://pubmed.ncbi.nlm.nih.gov/30046694
https://pubmed.ncbi.nlm.nih.gov/30046694
Publikováno v:
The Protein Journal
Recombinant human FIX concentrates (rhFIX) are essential in the treatment and prevention of bleeding in the bleeding disorder haemophilia B. However, due to the complex nature of FIX production yields are low which leads to high treatment costs. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9127ac5256581638fa0e9cdbbbdc0754
http://europepmc.org/articles/PMC3947961
http://europepmc.org/articles/PMC3947961
Publikováno v:
British Journal of Pharmaceutical Research. 4:2511-2524
Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy, University of Gothenburg, S-413 45, Sweden. Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Department of Clinical Pathology and Cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86f969f7c00c97cba821be583713dabf
https://doi.org/10.9734/bjpr/2014/10923
https://doi.org/10.9734/bjpr/2014/10923
Autor:
Karin J Johansson, Ann Lövgren, Kenny M Hansson, Cecilia Wingren, Karin Nelander, Dietmar Fries
Publikováno v:
Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 28(3)
Uncontrolled bleeding remains one of the leading causes of trauma-induced death. Treatment recommendations focus on fresh frozen plasma and blood cell transfusions, whereas plasma concentrates or single coagulation factors have been studied in recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb08d669e5194ba8c7e1867b2e1447f
https://pubmed.ncbi.nlm.nih.gov/27428015
https://pubmed.ncbi.nlm.nih.gov/27428015