Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ann L, White"'
Publikováno v:
Antibodies, Vol 11, Iss 2, p 29 (2022)
Since the approval of Rituximab in the late 1990s, the first chimeric monoclonal antibody for the treatment of non-Hodgkin lymphoma, antibody engineering for cancer immunotherapy has become a rapidly growing field, with almost 50 antibody therapeutic
Externí odkaz:
https://doaj.org/article/cabdf498f6a64cc283217759bc96448f
Autor:
Christian M. Orr, Hayden Fisher, Xiaojie Yu, Claude H.-T. Chan, Yunyun Gao, Patrick J. Duriez, Steven G. Booth, Isabel Elliott, Tatyana Inzhelevskaya, Ian Mockridge, Christine A. Penfold, Armin Wagner, Martin J. Glennie, Ann L. White, Jonathan W. Essex, Arwen R. Pearson, Mark S. Cragg, Ivo Tews
Publikováno v:
Science Immunology
Antibodies protect from infection, underpin successful vaccines and elicit therapeutic responses in otherwise untreatable cancers and autoimmune conditions. The human IgG2 isotype displays a unique capacity to undergo disulfide shuffling in the hinge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f26559ffaad774e3100f8f5c38f54b
https://pubmed.ncbi.nlm.nih.gov/35857582
https://pubmed.ncbi.nlm.nih.gov/35857582
Autor:
Robert J. Brown, Joshua R. Schultz, Kerry W.S. Ko, John S. Hill, Tanya A. Ramsamy, Ann L. White, Daniel L. Sparks, Zemin Yao
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 7, Pp 1306-1314 (2003)
Human hepatic lipase (hHL) mainly exists cell surface bound, whereas mouse HL (mHL) circulates in the blood stream. Studies have suggested that the carboxyl terminus of HL mediates cell surface binding. We prepared recombinant hHL, mHL, and chimeric
Externí odkaz:
https://doaj.org/article/98a41152971649969a457b20a49caa8c
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 11, Pp 1858-1864 (2001)
Combined lipase deficiency (cld) is a recessively inherited disorder in mice associated with a deficiency of LPL and hepatic lipase (HL) activity. LPL is synthesized in cld tissues but is retained in the endoplasmic reticulum (ER), whereas mouse HL (
Externí odkaz:
https://doaj.org/article/4d21f1ef6db94e49a865f24be8a9a70a
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 1, Pp 60-69 (2001)
Efforts to develop an in vitro model system to analyze apolipoprotein [a] (apo[a]) gene transcription, mRNA translation, and protein secretion have been complicated by the limited tissue and species distribution of apo[a] and the presence of regulato
Externí odkaz:
https://doaj.org/article/d1b7a6442dea4dceb9b9e6b46cab962a
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 9, Pp 1627-1635 (1999)
The addition and endoplasmic reticulum (ER) glucosidase processing of N-linked glycans is essential for the secretion of rat hepatic lipase (HL). Human HL is distinct from rat HL by the presence of four as opposed to two N-linked carbohydrate side ch
Externí odkaz:
https://doaj.org/article/b767a0559b6144929e8d45a165e4bede
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 2, Pp 275-286 (1999)
Plasma levels of atherogenic lipoprotein [a] (Lp[a]) vary over a 1000-fold range and are largely determined by the gene for its unique glycoprotein, apolipoprotein [a] (apo[a]). The apo[a] locus comprises more than 100 alleles, encoding proteins from
Externí odkaz:
https://doaj.org/article/372df0c1d9ec4febbd425d16d2f9a9a8
Autor:
Ann L. White, Mark S. Cragg, Tatyana Inzhelevskaya, H.T. Claude Chan, Ivo Tews, Xiaojie Yu, J. Sjef Verbeek, Leon Douglas, Ruth R. French, Martin J. Glennie, Hayden Fisher, Vikki English, Patrick J. Duriez, Jinny Kim, C. Ian Mockridge, Christine A. Penfold
Publikováno v:
Cancer Cell, 37(6), 850-866.e7. CELL PRESS
Cancer Cell
Cancer Cell
Summary Anti-CD40 monoclonal antibodies (mAbs) comprise agonists and antagonists, which display promising therapeutic activities in cancer and autoimmunity, respectively. We previously showed that epitope and isotype interact to deliver optimal agoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fe2c5159509a625490455880f35384
https://doi.org/10.1016/j.ccell.2020.04.013
https://doi.org/10.1016/j.ccell.2020.04.013
Autor:
Xiaojie, Yu, H T Claude, Chan, Christian M, Orr, Osman, Dadas, Steven G, Booth, Lekh N, Dahal, Christine A, Penfold, Lyn, O'Brien, C Ian, Mockridge, Ruth R, French, Patrick, Duriez, Leon R, Douglas, Arwen R, Pearson, Mark S, Cragg, Ivo, Tews, Martin J, Glennie, Ann L, White
Publikováno v:
Cancer cell. 33(4)
Anti-CD40 monoclonal antibodies (mAbs) that promote or inhibit receptor function hold promise as therapeutics for cancer and autoimmunity. Rules governing their diverse range of functions, however, are lacking. Here we determined characteristics of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32a6fca115b636323fb246c1334d2566
https://pubmed.ncbi.nlm.nih.gov/29634942
https://pubmed.ncbi.nlm.nih.gov/29634942
Publikováno v:
Blood. 127(9)
Monoclonal antibody (mAb) therapeutics are revolutionizing cancer treatment; however, not all tumors respond, and agent optimization is essential to improve outcome. It has become clear over recent years that isotype choice is vital to therapeutic su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c4973ced780981196197f64793ed45
https://pubmed.ncbi.nlm.nih.gov/26764357
https://pubmed.ncbi.nlm.nih.gov/26764357