Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo

Autor: Ann Kristin Frøyset, Amanda J. Edson, Naouel Gharbi, Essa A. Khan, Daniel Dondorp, Qing Bai, Ettore Tiraboschi, Maximiliano L. Suster, Joanne B. Connolly, Edward A. Burton, Kari E. Fladmark

Publikováno v: Redox Biology, Vol 16, Iss , Pp 237-247 (2018)

DJ-1, a Parkinson's disease-associated protein, is strongly up-regulated in reactive astrocytes in Parkinson's disease. This is proposed to represent a neuronal protective response, although the mechanism has not yet been identified. We have generate

Externí odkaz: https://doaj.org/article/b257c24988bd417aa9a616d71968481a

Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson’s Disease-Related Protein DJ-1

Autor: Essa A. Khan, Helena A. Hushagen, Amanda J. Edson, Inga Elda, Antonio Di Stefano, Ann Kristin Frøyset, Kari E. Fladmark

Publikováno v: Molecular Neurobiology. 56:8306-8322

DJ-1 is a protein with a wide range of functions importantly related to redox regulation in the cell. In humans, dysfunction of the PARK7 gene is associated with neurodegeneration and Parkinson's disease. Our objective was to establish a novel DJ-1 k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77c8af4f077522befe91d5cb76640bb
https://doi.org/10.1007/s12035-019-01667-w

Algal Toxin Azaspiracid-1 Induces Early Neuronal Differentiation and Alters Peripherin Isoform Stoichiometry

Autor: Krisna Rungruangsak-Torrissen, Kari E. Fladmark, Linda Veka Hjørnevik, Toril Anne Grønset, Ann Kristin Frøyset

Publikováno v: Marine Drugs
Volume 13
Issue 12
Pages 7390-7402
Marine Drugs; Volume 13; Issue 12; Pages: 7390-7402
Marine Drugs, Vol 13, Iss 12, Pp 7390-7402 (2015)

Azaspiracid-1 is an algal toxin that accumulates in edible mussels, and ingestion may result in human illness as manifested by vomiting and diarrhoea. When injected into mice, it causes neurotoxicological symptoms and death. Although it is well known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df575704f1033c5b9ed3db7c3bd7eef
https://doi.org/10.3390/md13127072

Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress

Autor: Lise Fismen, Ann Kristin Frøyset, Darina Gromyko, Vibeke H. Bull, Kari E. Fladmark, Linda Veka Hjørnevik, Therese Solstad, Jill A. Opsahl

Publikováno v: PROTEOMICS. 10:1494-1504

DJ-1 was originally identified to be an oncogenic product, but has later been shown to be highly multifunctional. DJ-1 plays a role in oxidative stress response and transcriptional regulation, and loss of its function leads to an early onset of Parki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea2e43c988dc7d361d0a6cbae4db334
https://doi.org/10.1002/pmic.200900586

Reintroduction of DJ-1 in Müller Cells Inhibits Retinal Degeneration in the DJ-1 Deficient Retina

Autor: Naouel Gharbi, Dagne Røise, Jorunn-Elise Førre, Amanda J. Edson, Helena A. Hushagen, Valentina Tronci, Ann-Kristin Frøyset, Kari E. Fladmark

Publikováno v: Antioxidants, Vol 10, Iss 12, p 1862 (2021)

The eye is continuously under oxidative stress due to high metabolic activity and reactive oxygen species generated by daily light exposure. The redox-sensitive protein DJ-1 has proven to be essential in order to protect retina and retinal pigment ep

Externí odkaz: https://doaj.org/article/e35a55465b814ce1b87e75cf33bbd411