Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ann Katrine Jakobsen"'
Autor:
Cinzia Tesauro, Anne Katrine Simonsen, Marie Bech Andersen, Kamilla Wandsoe Petersen, Emil Laust Kristoffersen, Line Algreen, Noriko Yokoyama Hansen, Anne Bech Andersen, Ann Katrine Jakobsen, Magnus Stougaard, Pavel Gromov, Birgitta R. Knudsen, Irina Gromova
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background Camptothecin (CPT) and its derivatives are currently used as second- or third-line treatment for patients with endocrine-resistant breast cancer (BC). These drugs convert nuclear enzyme DNA topoisomerase I (TOP1) to a cell poison
Externí odkaz:
https://doaj.org/article/5bdd00634203464bab2f0dbccd74d249
Autor:
Ann-Katrine Jakobsen, Josephine Geertsen Keller, María Gonzalez, Endika Martin-Encinas, Francisco Palacios, Concepcion Alonso, Birgitta Ruth Knudsen, Magnus Stougaard
Publikováno v:
Sensors, Vol 21, Iss 14, p 4832 (2021)
DNA sensors can be used as robust tools for high-throughput drug screening of small molecules with the potential to inhibit specific enzymes. As enzymes work in complex biological pathways, it is important to screen for both desired and undesired inh
Externí odkaz:
https://doaj.org/article/cd00288b6963464ca183cc462cd5f16e
Autor:
Joanna Proszek, Amit Roy, Ann-Katrine Jakobsen, Rikke Frøhlich, Birgitta R. Knudsen, Magnus Stougaard
Publikováno v:
Sensors, Vol 14, Iss 1, Pp 1195-1207 (2014)
Human topoisomerase I (hTopI) is an essential cellular enzyme. The enzyme is often upregulated in cancer cells, and it is a target for chemotherapeutic drugs of the camptothecin (CPT) family. Response to CPT-based treatment is dependent on hTopI acti
Externí odkaz:
https://doaj.org/article/87374361d474416883c9c7ce1e73c2ce
Autor:
Ann-Katrine Jakobsen, Sakineh Yuusufi, Line Bille Madsen, Peter Meldgaard, Birgitta R. Knudsen, Magnus Stougaard
Publikováno v:
Jakobsen, A K, Yuusufi, S, Madsen, L B, Meldgaard, P, Knudsen, B R & Stougaard, M 2022, ' TDP1 and TOP1 as targets in anticancer treatment of NSCLC : Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data ', Lung Cancer, vol. 164, pp. 23-32 . https://doi.org/10.1016/j.lungcan.2021.12.010
Objectives: Topoisomerase 1 (TOP1) is a drug target used in anticancer treatment of various cancer types. The effect of the TOP1 drugs can be counteracted by the enzymatic activity of tyrosyl-DNA phosphodiesterase 1 (TDP1). Thus, to elucidate the rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b1c704673e73ff07059ce5c38440af
https://pure.au.dk/portal/da/publications/tdp1-and-top1-as-targets-in-anticancer-treatment-of-nsclc(05d8dc98-0db1-43c9-ad57-f8da63558d2f).html
https://pure.au.dk/portal/da/publications/tdp1-and-top1-as-targets-in-anticancer-treatment-of-nsclc(05d8dc98-0db1-43c9-ad57-f8da63558d2f).html
Autor:
Magnus Stougaard, Ann-Katrine Jakobsen, Laura Øllegaard Johnsen, Rune Thomsen, Kasper Holm, Oskar Franch, Birgitta Ruth Knudsen, Rikke Riber-Hansen, Torben Steiniche, Benedicte Parm Ulhøi
Publikováno v:
Stougaard, M, Jakobsen, A-K, Johnsen, L Ø, Thomsen, R, Holm, K, Franch, O, Knudsen, B R, Riber-Hansen, R, Steiniche, T & Ulhøi, B P 2019, ' Comparison of FISH and NGS Based 1p/19q Co-Deletion in Gliomas ' .
Aarhus University
Aarhus University
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::52b95be89c25ef6c437a51948acb9624
https://pure.au.dk/portal/da/publications/comparison-of-fish-and-ngs-based-1p19q-codeletion-in-gliomas(72c5cb04-eb01-4774-bfd2-ff0bb1c0fc4d).html
https://pure.au.dk/portal/da/publications/comparison-of-fish-and-ngs-based-1p19q-codeletion-in-gliomas(72c5cb04-eb01-4774-bfd2-ff0bb1c0fc4d).html
Autor:
Ann Katrine Jakobsen, Irina Gromova, Birgitta R. Knudsen, Line Algreen, Anne Katrine W. Simonsen, Cinzia Tesauro, Kamilla Wandsoe Petersen, Marie Bech Andersen, Emil L. Kristoffersen, Pavel Gromov, Magnus Stougaard, Anne Bech Andersen, Noriko Yokoyama Hansen
Publikováno v:
BMC Cancer
Tesauro, C, Simonsen, A K, Andersen, M B, Petersen, K W, Kristoffersen, E L, Algreen, L, Hansen, N Y, Andersen, A B, Jakobsen, A K, Stougaard, M, Gromov, P, Knudsen, B R & Gromova, I 2019, ' Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells : a comparative study ', BMC Cancer, vol. 19, no. 1, 1158 . https://doi.org/10.1186/s12885-019-6371-0
BMC Cancer, Vol 19, Iss 1, Pp 1-15 (2019)
Tesauro, C, Simonsen, A K, Andersen, M B, Petersen, K W, Kristoffersen, E L, Algreen, L, Hansen, N Y, Andersen, A B, Jakobsen, A K, Stougaard, M, Gromov, P, Knudsen, B R & Gromova, I 2019, ' Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells : a comparative study ', BMC Cancer, vol. 19, no. 1, 1158 . https://doi.org/10.1186/s12885-019-6371-0
BMC Cancer, Vol 19, Iss 1, Pp 1-15 (2019)
BackgroundCamptothecin (CPT) and its derivatives are currently used as second- or third-line treatment for patients with endocrine-resistant breast cancer (BC). These drugs convert nuclear enzyme DNA topoisomerase I (TOP1) to a cell poison with the p
Autor:
Ana Costa Braga, Magnus Stougaard, Yvonne Bury, António Nogueira, Sandra Zekic Tomas, Birgitta Ruth Knudsen, Ioana Mihai, Ann-Katrine Jakobsen, Pavel G Malkov, Helena Vala, Rita Luis, Nina Oleynikova, Carmen Nóbrega, Georgios Androutsopoulos, Olga Kharlova
Publikováno v:
Virchows Archiv
Autor:
Ann-Katrine Jakobsen, Joanna Proszek, Magnus Stougaard, Henrik Hager, Birgitta R. Knudsen, Evelyn Benuja Samuel, Kristina Lystlund Lauridsen
Publikováno v:
Jakobsen, A-K, Lauridsen, K L, Samuel, E B, Proszek, J, Knudsen, B R, Hager, H & Stougaard, M 2015, ' Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue ', Experimental and Molecular Pathology, vol. 99, no. 1, pp. 56-64 . https://doi.org/10.1016/j.yexmp.2015.05.006
Topoisomerase I (TOP1) regulates DNA topology during replication and transcription whereas tyrosyl-DNA phosphodiesterase 1 (TDP1) is involved in the repair of several types of DNA damages, including damages from defective TOP1 catalysis. TOP1 is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b2c8bac3a62f7942fc30b1d2133a19
https://pure.au.dk/portal/da/publications/correlation-between-topoisomerase-i-and-tyrosyldna-phosphodiesterase-1-activities-in-nonsmall-cell-lung-cancer-tissue(4b5f5554-eaae-4c8c-ac56-fb9c1898d719).html
https://pure.au.dk/portal/da/publications/correlation-between-topoisomerase-i-and-tyrosyldna-phosphodiesterase-1-activities-in-nonsmall-cell-lung-cancer-tissue(4b5f5554-eaae-4c8c-ac56-fb9c1898d719).html
Autor:
Ann-Katrine Jakobsen, Magnus Stougaard
Publikováno v:
Jakobsen, A-K & Stougaard, M 2015, ' Combining a nanosensor and ELISA for measurement of tyrosyl-dna phosphodiesterase 1 (tdp1) activity and protein amount in cell and tissue extract ', Nano Life, vol. 05, no. 02 . https://doi.org/10.1142/S1793984415410019
Tyrosyl-DNA Phosphodiesterase 1 (TDP1) was initially discovered by its ability to remove topoisomerase I (TOPI) covalently trapped to DNA. However, it has since been found to be involved in the repair of a number of DNA lesions other than TOPI–DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3e024525ddd886407b00779b1188d0
https://pure.au.dk/portal/da/publications/combining-a-nanosensor-and-elisa-for-measurement-of-tyrosyldna-phosphodiesterase-1-tdp1-activity-and-protein-amount-in-cell-and-tissue-extract(762e4437-7c98-4a0f-86e1-a4e6324e5ab3).html
https://pure.au.dk/portal/da/publications/combining-a-nanosensor-and-elisa-for-measurement-of-tyrosyldna-phosphodiesterase-1-tdp1-activity-and-protein-amount-in-cell-and-tissue-extract(762e4437-7c98-4a0f-86e1-a4e6324e5ab3).html
Autor:
Ann-Katrine Jakobsen, Sakineh Yuusufi, Line Bille Madsen, Birgitta Ruth Knudsen, Magnus Stougaard
Publikováno v:
Aarhus University
Jakobsen, A-K, Yuusufi, S, Madsen, L B, Knudsen, B R & Stougaard, M 2018, ' Potential co-Regulation of TOP1 and TDP1 in 130 Paired Human NSCLC Tissue Samples ', GRC DNA Topoisomerases in Biology and Medicine, 29/07/2018-03/08/2018 .
Jakobsen, A-K, Yuusufi, S, Madsen, L B, Knudsen, B R & Stougaard, M 2018, ' Potential co-Regulation of TOP1 and TDP1 in 130 Paired Human NSCLC Tissue Samples ', GRC DNA Topoisomerases in Biology and Medicine, 29/07/2018-03/08/2018 .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::48f617f43f512015395374d200f733d6
https://pure.au.dk/portal/en/publications/potential-coregulation-of-top1-and-tdp1-in-130-paired-human-nsclc-tissue-samples(8acea446-3905-4a5e-a725-4f909f5f4530).html
https://pure.au.dk/portal/en/publications/potential-coregulation-of-top1-and-tdp1-in-130-paired-human-nsclc-tissue-samples(8acea446-3905-4a5e-a725-4f909f5f4530).html