A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors

Autor: Ann-Katrine Jakobsen, Josephine Geertsen Keller, María Gonzalez, Endika Martin-Encinas, Francisco Palacios, Concepcion Alonso, Birgitta Ruth Knudsen, Magnus Stougaard

Publikováno v: Sensors, Vol 21, Iss 14, p 4832 (2021)

DNA sensors can be used as robust tools for high-throughput drug screening of small molecules with the potential to inhibit specific enzymes. As enzymes work in complex biological pathways, it is important to screen for both desired and undesired inh

Externí odkaz: https://doaj.org/article/cd00288b6963464ca183cc462cd5f16e

TDP1 and TOP1 as targets in anticancer treatment of NSCLC:Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data

Autor: Ann-Katrine Jakobsen, Sakineh Yuusufi, Line Bille Madsen, Peter Meldgaard, Birgitta R. Knudsen, Magnus Stougaard

Publikováno v: Jakobsen, A K, Yuusufi, S, Madsen, L B, Meldgaard, P, Knudsen, B R & Stougaard, M 2022, ' TDP1 and TOP1 as targets in anticancer treatment of NSCLC : Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data ', Lung Cancer, vol. 164, pp. 23-32 . https://doi.org/10.1016/j.lungcan.2021.12.010

Objectives: Topoisomerase 1 (TOP1) is a drug target used in anticancer treatment of various cancer types. The effect of the TOP1 drugs can be counteracted by the enzymatic activity of tyrosyl-DNA phosphodiesterase 1 (TDP1). Thus, to elucidate the rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b1c704673e73ff07059ce5c38440af
https://pure.au.dk/portal/da/publications/tdp1-and-top1-as-targets-in-anticancer-treatment-of-nsclc(05d8dc98-0db1-43c9-ad57-f8da63558d2f).html

Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study

Autor: Ann Katrine Jakobsen, Irina Gromova, Birgitta R. Knudsen, Line Algreen, Anne Katrine W. Simonsen, Cinzia Tesauro, Kamilla Wandsoe Petersen, Marie Bech Andersen, Emil L. Kristoffersen, Pavel Gromov, Magnus Stougaard, Anne Bech Andersen, Noriko Yokoyama Hansen

Publikováno v: BMC Cancer
Tesauro, C, Simonsen, A K, Andersen, M B, Petersen, K W, Kristoffersen, E L, Algreen, L, Hansen, N Y, Andersen, A B, Jakobsen, A K, Stougaard, M, Gromov, P, Knudsen, B R & Gromova, I 2019, ' Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells : a comparative study ', BMC Cancer, vol. 19, no. 1, 1158 . https://doi.org/10.1186/s12885-019-6371-0
BMC Cancer, Vol 19, Iss 1, Pp 1-15 (2019)

BackgroundCamptothecin (CPT) and its derivatives are currently used as second- or third-line treatment for patients with endocrine-resistant breast cancer (BC). These drugs convert nuclear enzyme DNA topoisomerase I (TOP1) to a cell poison with the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193553046aae71ca9689e58dd225da3d
https://pubmed.ncbi.nlm.nih.gov/31783818

Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue

Autor: Ann-Katrine Jakobsen, Joanna Proszek, Magnus Stougaard, Henrik Hager, Birgitta R. Knudsen, Evelyn Benuja Samuel, Kristina Lystlund Lauridsen

Publikováno v: Jakobsen, A-K, Lauridsen, K L, Samuel, E B, Proszek, J, Knudsen, B R, Hager, H & Stougaard, M 2015, ' Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue ', Experimental and Molecular Pathology, vol. 99, no. 1, pp. 56-64 . https://doi.org/10.1016/j.yexmp.2015.05.006

Topoisomerase I (TOP1) regulates DNA topology during replication and transcription whereas tyrosyl-DNA phosphodiesterase 1 (TDP1) is involved in the repair of several types of DNA damages, including damages from defective TOP1 catalysis. TOP1 is the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b2c8bac3a62f7942fc30b1d2133a19
https://pure.au.dk/portal/da/publications/correlation-between-topoisomerase-i-and-tyrosyldna-phosphodiesterase-1-activities-in-nonsmall-cell-lung-cancer-tissue(4b5f5554-eaae-4c8c-ac56-fb9c1898d719).html

Potential co-Regulation of TOP1 and TDP1 in 130 Paired Human NSCLC Tissue Samples

Autor: Ann-Katrine Jakobsen, Sakineh Yuusufi, Line Bille Madsen, Birgitta Ruth Knudsen, Magnus Stougaard

Publikováno v: Aarhus University
Jakobsen, A-K, Yuusufi, S, Madsen, L B, Knudsen, B R & Stougaard, M 2018, ' Potential co-Regulation of TOP1 and TDP1 in 130 Paired Human NSCLC Tissue Samples ', GRC DNA Topoisomerases in Biology and Medicine, 29/07/2018-03/08/2018 .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::48f617f43f512015395374d200f733d6
https://pure.au.dk/portal/en/publications/potential-coregulation-of-top1-and-tdp1-in-130-paired-human-nsclc-tissue-samples(8acea446-3905-4a5e-a725-4f909f5f4530).html