Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ann Jay Tong"'
Autor:
Siri Tähtinen, Ira Mellman, Christopher Kemball, Diamanda Rigas, Emily Freund, Rebecca Leylek, Ann-Jay Tong, Anna-Maria Herzner, Shirley Ng Palace, Sara Wichner, Craig Blanchette, Benjamin Haley, Lélia Delamarre
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/522169f677fe4b9e8b745e56c64817bb
Autor:
Saba R. Aliyari, Amir Ali Ghaffari, Olivier Pernet, Kislay Parvatiyar, Yao Wang, Hoda Gerami, Ann-Jay Tong, Laurent Vergnes, Armin Takallou, Adel Zhang, Xiaochao Wei, Linda D. Chilin, Yuntao Wu, Clay F. Semenkovich, Karen Reue, Stephen T. Smale, Benhur Lee, Genhong Cheng
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1624-1635 (2022)
SARS-CoV-2 is an emerging viral pathogen and a major global public health challenge since December of 2019, with limited effective treatments throughout the pandemic. As part of the innate immune response to viral infection, type I interferons (IFN-I
Externí odkaz:
https://doaj.org/article/478f8bc3c0c24622b4fbbf7fef87f486
Autor:
Yu Kong, Christopher M. Rose, Ashley A. Cass, Alexander G. Williams, Martine Darwish, Steve Lianoglou, Peter M. Haverty, Ann-Jay Tong, Craig Blanchette, Matthew L. Albert, Ira Mellman, Richard Bourgon, John Greally, Suchit Jhunjhunwala, Haiyin Chen-Harris
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Treatment with demethylation agents can reactivate transposable elements. Here in glioblastoma, the authors also show that this is accompanied by de novo presentation of TE-derived peptides on MHC class I molecules.
Externí odkaz:
https://doaj.org/article/4f372d927b9744d19d8bbddc89834da4
Autor:
Siri Tahtinen, Ann-Jay Tong, Patricia Himmels, Jaehak Oh, Andres Paler-Martinez, Leesun Kim, Sara Wichner, Yoko Oei, Mark J. McCarron, Emily C. Freund, Zhainib Adel Amir, Cecile C. de la Cruz, Benjamin Haley, Craig Blanchette, Jill M. Schartner, Weilan Ye, Mahesh Yadav, Ugur Sahin, Lélia Delamarre, Ira Mellman
Publikováno v:
Nature Immunology. 23:532-542
The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-limiting systemic inflammatory responses in humans that were not predicted from preclinical studies. Here, we show that the 'interleukin 1 (IL-1)-interleukin 1 re
Autor:
Hem Gurung, Amy Heidersbach, Martine Darwish, Pamela Chan, Jenny Li, Maureen Beresini, Oliver Zill, Andrew Wallace, Ann-Jay Tong, Dan Hascall, Eric Torres, Andy Chang, Kenny 'Hei-Wai' Lou, Yassan Abdolazimi, Amanda Moore, Uzodinma Uche, Melanie Laur, Richard Notturno, Peter J.R. Ebert, Craig Blanchette, Benjamin Haley, Christopher M. Rose
SummaryStrategies for maximizing the potency and specificity of cancer immunotherapies have sparked efforts to identify recurrent epitopes presented in the context of defined tumor-associated neoantigens. Discovering these “neoepitopes” can be di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6317922554eb98fcf714d679f289ec76
https://doi.org/10.1101/2022.10.27.513529
https://doi.org/10.1101/2022.10.27.513529
Autor:
Saba R. Aliyari, Amir Ali Ghaffari, Olivier Pernet, Kislay Parvatiyar, Yao Wang, Hoda Gerami, Ann-Jay Tong, Laurent Vergnes, Armin Takallou, Adel Zhang, Xiaochao Wei, Linda D. Chilin, Yuntao Wu, Clay F. Semenkovich, Karen Reue, Stephen T. Smale, Benhur Lee, Genhong Cheng
Publikováno v:
Acta pharmaceutica Sinica. B, vol 12, iss 4
SARS-CoV-2 is an emerging viral pathogen and a major global public health challenge since December of 2019, with limited effective treatments throughout the pandemic. As part of the innate immune response to viral infection, type I interferons (IFN-I
Autor:
Michelle M Lissner, Brandon J Thomas, Kathleen Wee, Ann-Jay Tong, Tobias R Kollmann, Stephen T Smale
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132061 (2015)
A variety of age-related differences in the innate and adaptive immune systems have been proposed to contribute to the increased susceptibility to infection of human neonates and older adults. The emergence of RNA sequencing (RNA-seq) provides an opp
Externí odkaz:
https://doaj.org/article/64bbfa95ae97453eb86e3cd281e01255
Autor:
Ira Mellman, Siri Tahtinen, Leesun Kim, Ugur Sahin, Patricia Himmels, Yoko Oei, Andres Paler-Martinez, Jill Schartner, Emily C. Freund, Craig Blanchette, Weilan Ye, Benjamin Haley, Ann-Jay Tong, Sara Wichner, Cecile de la Cruz, Jaehak Oh, Mahesh Yadav, Mark McCarron, Lélia Delamarre, Zhainib Adel Amir
Excessive systemic inflammation is characteristic to various acute conditions including sepsis, viral infections and immunotherapy-induced adverse events such as cytokine release syndrome (CRS). Recently, several clinical trials evaluating variants o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db2e7afb3cdd01228b8c45dad26e9d7b
https://doi.org/10.21203/rs.3.rs-378991/v1
https://doi.org/10.21203/rs.3.rs-378991/v1
Autor:
Craig Blanchette, Peter M. Haverty, Haiyin Chen-Harris, Steve Lianoglou, Martine Darwish, Richard Bourgon, Alexander G. Williams, Ira Mellman, Ann Jay Tong, Christopher M. Rose, Suchit Jhunjhunwala, John M. Greally, Ashley A. Cass, Matthew L. Albert, Yu Kong
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Profound global loss of DNA methylation is a hallmark of many cancers. One potential consequence of this is the reactivation of transposable elements (TEs) which could stimulate the immune system via cell-intrinsic antiviral responses. Here, we devel
Autor:
Ira Mellman, Richard Bourgon, Haiyin Chen-Harris, Pete Haverty, Christopher M. Rose, Greally John, Craig Blanchette, Ann-Jay Tong, Martine Darwish, Steve Lianoglou, Matthew L. Albert, Yu Kong, Suchit Jhunjhunwala, Ashley A. Cass
Profound loss of DNA methylation is a well-recognized hallmark of cancer. Given its role in silencing transposable elements (TEs), we hypothesized that extensive TE expression occurs in tumors with highly demethylated DNA. We developed REdiscoverTE,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689971f100f57fda91825802b742ae0f
https://doi.org/10.1101/388215
https://doi.org/10.1101/388215