Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Ann J. Feeney"'
Autor:
Khalid H. Bhat, Saurabh Priyadarshi, Sarah Naiyer, Xinyan Qu, Hammad Farooq, Eden Kleiman, Jeffery Xu, Xue Lei, Jose F. Cantillo, Robert Wuerffel, Nicole Baumgarth, Jie Liang, Ann J. Feeney, Amy L. Kenter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Here the authors show enhancers in the Igh locus play a major role in configuring locus architecture and in V(D)J recombination, and identify a link between enhancer hub formation, locus contraction and cohesin-mediated loop extrusion.
Externí odkaz:
https://doaj.org/article/ba000a65998d49268875ffe123c8814e
Autor:
E. Mauricio Barajas-Mora, Lindsay Lee, Hanbin Lu, J. Andrés Valderrama, Elisabet Bjanes, Victor Nizet, Ann J. Feeney, Ming Hu, Cornelis Murre
Publikováno v:
Nature Immunology. 24:320-336
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b55382864a75517c1080f9e3051b188
https://doi.org/10.1038/s41590-022-01402-z
https://doi.org/10.1038/s41590-022-01402-z
Autor:
Amy L. Kenter, Ann J. Feeney
Publikováno v:
F1000Research, Vol 8 (2019)
Vast repertoires of unique antigen receptors are created in developing lymphocytes. The antigen receptor loci contain many variable (V), diversity (D), and joining (J) gene segments that are arrayed across very large genomic expanses and are joined t
Externí odkaz:
https://doaj.org/article/2422c4579f9445bb84d0b6239eba5c92
Autor:
James E Voss, Alicia Gonzalez-Martin, Raiees Andrabi, Roberta P Fuller, Ben Murrell, Laura E McCoy, Katelyn Porter, Deli Huang, Wenjuan Li, Devin Sok, Khoa Le, Bryan Briney, Morgan Chateau, Geoffrey Rogers, Lars Hangartner, Ann J Feeney, David Nemazee, Paula Cannon, Dennis R Burton
Publikováno v:
eLife, Vol 8 (2019)
We have developed a method to introduce novel paratopes into the human antibody repertoire by modifying the immunoglobulin (Ig) genes of mature B cells directly using genome editing technologies. We used CRISPR-Cas9 in a homology directed repair stra
Externí odkaz:
https://doaj.org/article/672ae969491c41729fd1ce5dbcadba72
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
To date there has not been a study directly comparing relative Igκ rearrangement frequencies obtained from genomic DNA (gDNA) and cDNA and since each approach has potential biases, this is an important issue to clarify. Here we used deep sequencing
Externí odkaz:
https://doaj.org/article/a6c3813cd2814dd4825df56ba34eb245
Autor:
Salvatore Loguercio, E. Mauricio Barajas-Mora, Han-Yu Shih, Michael S. Krangel, Ann J. Feeney
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
CCCTC-binding factor (CTCF) is largely responsible for the 3D architecture of the genome, in concert with the action of cohesin, through the creation of long-range chromatin loops. Cohesin is hypothesized to be the main driver of these long-range chr
Externí odkaz:
https://doaj.org/article/1c04b67f6ffa4dc69583191914d4ed6e
Autor:
Khalid H. Bhat, Saurabh Priyardarshi, Sarah Naiyer, X. Qu, Hammad Farooq, Eden Kleiman, J. Xu, X. Lei, Jose F. Cantillo, Robert Wuerffel, Nicole Baumgarth, Jie Liang, Ann J. Feeney, Amy L. Kenter
The Igh locus is organized into a developmentally regulated topologically associated domain (TAD) that is divided into subTADs. Here we identify a series of novel enhancers (NEs) that collaborate to configure the locus, determine transcriptional pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::838df64ddbff55c839150c2b816a2171
https://doi.org/10.1101/2022.05.23.492988
https://doi.org/10.1101/2022.05.23.492988
Autor:
E Mauricio Barajas-Mora, Ann J. Feeney
Publikováno v:
Transcription
Enhancers are defined as regulatory elements that control transcription in a cell-type and developmental stage-specific manner. They achieve this by physically interacting with their cognate gene promoters. Significantly, these interactions can occur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d98e91bfd4a8f3332455a45722c86dc
https://doi.org/10.1080/21541264.2019.1699383
https://doi.org/10.1080/21541264.2019.1699383
Autor:
Celia R. Espinoza, Ann J. Feeney
Publikováno v:
BioTechniques, Vol 41, Iss 4, Pp 404-408 (2006)
Externí odkaz:
https://doaj.org/article/03f70045246f44d7834a5b01a37f1999
Autor:
Tessa Arends, Haiqun Jia, Ann J. Feeney, Cornelis Murre, Jennifer R. Knapp, James Hagman, Desiree Straign, Thomas Danhorn, Laura Harmacek, Carissa Dege, Alexandra Bortnick, Brian P. O'Connor, Courtney J. Fleenor, Sonia M. Leach, Kendra Walton
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The ontogeny of B cells in the bone marrow is regulated by a complex network of proteins and signaling pathways. Regulation of gene expression through transcriptional activation and repression is necessary for establishing and maintainin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22990c29904e3e15b7373e5ce9184430
https://doi.org/10.1073/pnas.1821301116
https://doi.org/10.1073/pnas.1821301116