Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Ann Hwang"'
Autor:
Li-Ann Hwang, Santha Vaithilingam, Jason Wei Jian Ng, Mahendhiran Nair, Pervaiz Ahmed, Kamarul Imran Musa
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301383 (2024)
BackgroundVaccination has been one of the most effective preventive strategies to contain the COVID-19 pandemic. However, as the COVID-19 vaccines' effect wanes off after some time and given their reduced level of protection against mutation strains
Externí odkaz:
https://doaj.org/article/f9d7d53a1c4048b481d99858632c9666
Autor:
Xin Yu Koh, Xiao Hui Koh, Diana Spiegelberg, Preeti Jha, Marika Nestor, Le-ann Hwang, Ban Xiong Tan, David Philip Lane
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The RON receptor tyrosine kinase is an exceptionally interesting target in oncology and immunology. It is not only overexpressed in a wide variety of tumors but also has been shown to be expressed on myeloid cells associated with tumor infil
Externí odkaz:
https://doaj.org/article/7630592839b745e4807f205edee05a36
Autor:
Santha Vaithilingam, Li-Ann Hwang, Mahendhiran Nair, Jason Wei Jian Ng, Pervaiz Ahmed, Kamarul Imran Musa
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282520 (2023)
BackgroundSporadic outbreaks of COVID-19 remain a threat to public healthcare, especially if vaccination levels do not improve. As Malaysia begins its transition into the endemic phase, it is essential to identify the key determinants of COVID-19 vac
Externí odkaz:
https://doaj.org/article/5ac349577b7a4eb99d8b9f71b43316e6
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0268926 (2022)
BackgroundAs the vaccination drive against the coronavirus disease (COVID-19) in Malaysia progresses rapidly, the main challenge will gradually shift from procuring and distributing vaccines to ensuring the broadest possible acceptance among all popu
Externí odkaz:
https://doaj.org/article/0f7e8100ab534aa49110e5e575a33575
Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine
Autor:
Le-Ann Hwang, Beng Hooi Phang, Oi Wah Liew, Jabed Iqbal, Xiao Hui Koh, Xin Yu Koh, Rashidah Othman, Yuezhen Xue, A. Mark Richards, David P. Lane, Kanaga Sabapathy
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109498- (2021)
Externí odkaz:
https://doaj.org/article/f266ff945e92477783e50248e2c7ba7a
Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine
Autor:
Le-Ann Hwang, Beng Hooi Phang, Oi Wah Liew, Jabed Iqbal, Xiao Hui Koh, Xin Yu Koh, Rashidah Othman, Yuezhen Xue, A. Mark Richards, David P. Lane, Kanaga Sabapathy
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 299-312 (2018)
Summary: The large number of mutations identified across all cancers represents an untapped reservoir of targets that can be useful for therapeutic targeting if highly selective, mutation-specific reagents are available. We report here our attempt to
Externí odkaz:
https://doaj.org/article/f1c84eea464845cc98ed94b45e71f1c7
Autor:
David P. Lane, Le-Ann Hwang, Siti Aishah B. Rahmat, Hui Chin Goh, Xin Yu Koh, Shunsheng Zheng
Contains primer sequences, additional materials and methods to complement main article.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b37c9e65a86bcf2c28b57ce4daaf357
https://doi.org/10.1158/0008-5472.22414832
https://doi.org/10.1158/0008-5472.22414832
Autor:
David P. Lane, Le-Ann Hwang, Siti Aishah B. Rahmat, Hui Chin Goh, Xin Yu Koh, Shunsheng Zheng
Supplementary Figure S1. Related to Figure 1. Unravelling the mechanism of C646 action.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef9827e23508f52f106cc5eaf689fb3
https://doi.org/10.1158/0008-5472.22414850
https://doi.org/10.1158/0008-5472.22414850
Autor:
David P. Lane, Le-Ann Hwang, Siti Aishah B. Rahmat, Hui Chin Goh, Xin Yu Koh, Shunsheng Zheng
Chemotoxicity due to unwanted p53 activation in the bone marrow remains an unmet clinical challenge. Doxorubicin, a first-line chemotherapy drug, often causes myelosuppression in patients, thus limiting its effectiveness. In this study, we discovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beef2ddaeff5e1cc597ebe24c809cede
https://doi.org/10.1158/0008-5472.c.6509087.v1
https://doi.org/10.1158/0008-5472.c.6509087.v1
Autor:
David P. Lane, Le-Ann Hwang, Siti Aishah B. Rahmat, Hui Chin Goh, Xin Yu Koh, Shunsheng Zheng
Contain Legends for Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f517a296f5b6bac022847556ac4deb
https://doi.org/10.1158/0008-5472.22414835
https://doi.org/10.1158/0008-5472.22414835