Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ann Horowitz"'
Autor:
Diana Montgomery, Anish Mehta, Elisabeth Riedl, Christine Bangert, Ann Horowitz, Frank van Aarle, Tamara Kopp, Xiaoli Shirley Hou, Elli K. Greisenegger, Sauzanne Khalilieh, Thomas Marbury, Wendy M. Blumenschein, Anthe S. Zandvliet, Edward P. Bowman, Claus Zachariae, Danlin Xu, Harald Kittler, Terrill K. McClanahan
Publikováno v:
Nature. 521:222-226
A proof-of-concept phase I clinical trial demonstrates that targeting interleukin (IL)-23 with an antibody that binds to the p19 subunit leads to clinical improvement of disease in patients with moderate to severe psoriasis. Sauzanne Khalilieh and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaaf0fcbaa1584a540a9410beab9e207
https://doi.org/10.1038/nature14175
https://doi.org/10.1038/nature14175
Publikováno v:
Drug development and industrial pharmacy. 43(7)
A new improved mometasone furoate (Elocon™) cream with an emulsification system that produces a stable emulsion has been developed. In order to register the product in various markets, it was essential to ensure the cream was topically well tolerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eaa01cf7c80dcf3ebe43f4184aa38c7
https://pubmed.ncbi.nlm.nih.gov/28277845
https://pubmed.ncbi.nlm.nih.gov/28277845
Autor:
Paula A. Schneider, David A. Parry, Brian M. Thomas, Tomoko Freshwater, Steven D. Gore, Judith E. Karp, Douglas E. Gladstone, Margaret M. Showel, Scott H. Kaufmann, Karen Mackey, Randi Isaacs, Hetty E. Carraway, B. Douglas Smith, Jacqueline Greer, Kevin A. Peterson, Sabine Loechner, Michael A. McDevitt, Keith W. Pratz, Mark J. Levis, Christopher Sorge, Karen S. Flatten, Jo Ann Horowitz
Publikováno v:
Clinical Cancer Research. 18:6723-6731
Purpose: Incorporation of cytarabine into DNA activates checkpoint kinase 1 (Chk1), which stabilizes stalled replication forks, induces S-phase slowing, and diminishes cytarabine cytotoxicity. The selective Chk1 inhibitor SCH 900776 abrogates cytarab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d6d61eed76d448e2f7970f09db9e72
https://doi.org/10.1158/1078-0432.ccr-12-2442
https://doi.org/10.1158/1078-0432.ccr-12-2442
Autor:
Anish Mehta, Tamara Kopp, Elisabeth Riedl, Christine Bangert, Edward Bowman, Elli Greisenegger, Ann Horowitz, Harald Kittler, Wendy Blumenschein, Terrill McClanahan, Thomas Marbury, Claus Zachariae, Danlin Xu, Xiaoli (Shirley) Hou, Anthe Zandvliet, Diana Montgomery, Frank van Aarle, Sauzanne Khalilieh
Publikováno v:
Protocol Exchange.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3abf99dc33ac45ed485328fef314adb
https://doi.org/10.1038/protex.2015.025
https://doi.org/10.1038/protex.2015.025
Autor:
Ann Horowitz, Christine Xu, Diana Montgomery, Marianne van Vugt, Shirley Glasgow, Joanne Marjason, Anish Mehta, Sauzanne Khalilieh, Anthe S. Zandvliet
Publikováno v:
International journal of clinical pharmacology and therapeutics. 53(2)
Objective To evaluate the effect of ethnicity on the pharmacokinetics (PK) of tildrakizumab, a novel anti-IL-23 monoclonal antibody for the treatment of psoriasis. Materials and methods This was an open-label, 2-part study in healthy adult subjects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61f9f814f52f4479bfecf8df15c8a8a
https://pubmed.ncbi.nlm.nih.gov/25546162
https://pubmed.ncbi.nlm.nih.gov/25546162
Autor:
Stephen R. Indelicato, Shu Fen Wen, Jeremy Shinoda, I A Atencio, Alan P. Venook, Daniel C. Maneval, Mary Lynn Musco, Robert S. Warren, Beth Hutchins, Ronald Bordens, Grace Michael, M Fritz, Karen Kolz, Sheila Jacobs, Jo Ann Horowitz
Publikováno v:
Cancer Gene Therapy. 13:169-181
The major focus of intrahepatic arterial (IHA) administration of adenoviruses (Ad) has been on safety. Currently, there is little published data on the biological responses to Ad when administered via this route. As part of a Phase I study, we evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666578d1869f0c3a2762d60d466f3397
https://doi.org/10.1038/sj.cgt.7700870
https://doi.org/10.1038/sj.cgt.7700870
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 18:229-234
This double-blind, double-dummy, crossover study evaluated the tolerability of high-dose formoterol and salbutamol. Sixteen adults with mild/moderate persistent asthma (FEV1or = 70% predicted) were randomized to receive either formoterol 36 microg th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bcc3353ba453606d7e3c83d7ba0d54
https://doi.org/10.1016/j.pupt.2004.12.011
https://doi.org/10.1016/j.pupt.2004.12.011
Autor:
Ann Horowitz, Martine Hubert, Suzanne K. Swan, James F. McLeod, Silke Appel-Dingemanse, Stuart Osborne, Latifa Alladina, Larry Lambrecht, Honghui Zhou
Publikováno v:
The Journal of Clinical Pharmacology. 43:359-364
Tegaserod (HTF 919), a selective 5-HT4 receptor partial agonist with promotile activity throughout the gastrointestinal tract, is in development for the treatment of irritable bowel syndrome. In an open-label, parallel-group study, the pharmacokineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186cf20b888a487565756118b262723f
https://doi.org/10.1177/0091270003251823
https://doi.org/10.1177/0091270003251823
Autor:
Vikas Mahavni, Richard E. Buller, Stan Petrauskas, R. Kreienberg, Dennis J. Slamon, Mark D. Pegram, Jo Ann Horowitz, Beth Y. Karlan, Ingo B Runnebaum, Mark S. Shahin
Publikováno v:
Cancer Gene Therapy. 9:567-572
Objective: We have previously reported the safety, efficient gene transfer, and favorable CA125 responses of individuals with recurrent ovarian cancer treated by p53 gene replacement with the adenoviral vector SCH 58500. The purpose of the present in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd794684a2d224987554646d048bf0a0
https://doi.org/10.1038/sj.cgt.7700473
https://doi.org/10.1038/sj.cgt.7700473
Autor:
James F. McLeod, James E. Foley, Steven E. Kahn, Damayanthi Devineni, Chyi-Hung Hsu, Monica Ligueros-Saylan, Ann Horowitz, William Howell, Brenda Montgomery
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 86:5824-5829
Insulin secretion is impaired in type 2 diabetes with the early response being essentially absent. The loss of this early insulin secretion is hypothesized to be important in the deterioration of glucose tolerance. To determine whether enhancement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce98b1d1845f522a2007b189ab10df4
https://doi.org/10.1210/jcem.86.12.8105
https://doi.org/10.1210/jcem.86.12.8105