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Akademický článek

Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia

Autor: Douglas B. Cines, Serge V. Yarovoi, Sergei V. Zaitsev, Tatiana Lebedeva, Lubica Rauova, Mortimer Poncz, Gowthami M. Arepally, Sanjay Khandelwal, Victoria Stepanova, Ann H. Rux, Adam Cuker, Cecilia Guo, Linnette Mae Ocariza, Richard J. Travers, Stephanie A. Smith, Hugh Kim, James H. Morrissey, Edward M. Conway

Publikováno v: Blood Advances, Vol 1, Iss 1, Pp 62-74 (2016)

Abstract: Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder initiated by antibodies to complexes between platelet factor 4 (PF4) and heparin. The risk of recurrent thromboembolism persists after heparin is cleared and platelet activatio

Externí odkaz: https://doaj.org/article/05425711ef5040eb80a2b8ffcd281b26

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Erythrocytes identify complement activation in patients with COVID-19

Autor: Ariel R. Weisman, Caroline A. G. Ittner, Ann H. Rux, Nuala J. Meyer, S. Murphy, Wen-Chao Song, John D. Lambris, Nilam S. Mangalmurti, Michael R. Betts, Leticia Kuri-Cervantes, Douglas B. Cines, John P. Reilly, E. John Wherry, M. Betina Pampena, L. K. Metthew Lam

Publikováno v: Am J Physiol Lung Cell Mol Physiol

COVID-19, the disease caused by the SARS-CoV-2 virus, can progress to multi-organ failure characterized by respiratory insufficiency, arrhythmias, thromboembolic complications and shock. The mortality of patients hospitalized with COVID-19 is unaccep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac15f5c715ea0060da803fb9e3599170
https://europepmc.org/articles/PMC8384475/

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FcRn augments induction of tissue factor activity by IgG-containing immune complexes

Autor: Mortimer Poncz, Amrita Sarkar, Douglas B. Cines, Alan E. Mast, Sriram Krishnaswamy, Jonathan J. Hubbard, Keith R. McCrae, M. Anna Kowalska, Guohua Zhao, Richard S. Blumberg, Victoria Stepanova, Lubica Rauova, Laurence J. Blumberg, Michal Pyzik, Ann H. Rux, Sergei Zaitsev

Publikováno v: Blood

Thromboembolism complicates disorders caused by immunoglobulin G (IgG)–containing immune complexes (ICs), but the underlying mechanisms are incompletely understood. Prior evidence indicates that induction of tissue factor (TF) on monocytes, a pivot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a523d72fd38bec0bed017bf44acb364
https://europepmc.org/articles/PMC7273830/

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Complement Regulates the Procoagulant Effects of HIT Immune Complexes

Autor: Mortimer Poncz, Douglas B. Cines, Ann H. Rux, Sanjay Khandelwal, Sooho Samuel Myoung, Gowthami M. Arepally, Serge Yarovoi, Lubica Rauova, Madelaine Duarte, Ayiesha Barnes, Alexandra Johnson, Grace M. Lee

Publikováno v: Blood. 136:11-12

Heparin induced thrombocytopenia (HIT) is a prothrombotic disorder mediated by ultra-large immune complexes (ULICs) containing IgG antibodies bound to multivalent complexes of platelet factor 4 (PF4) and heparin (H). HIT ULICs activate cellular FcγI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5236ea172799aa2c712b6185087ec05d
https://doi.org/10.1182/blood-2020-138631

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Platelet Factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment

Autor: Zahra F. Parker, Douglas B. Cines, Amber M. Riblett, Mortimer Poncz, Fang-Hua Lee, Bruce S. Sachais, Lubica Rauova, Ann H. Rux, Robert W. Doms

Publikováno v: AIDS Research and Human Retroviruses. 32:705-717

Platelet factor 4 (PF4) has been recently shown to inhibit infection by a broad range of human immunodeficiency virus type 1 (HIV-1) isolates in vitro. We found that the inhibitory effects of PF4 are limited to a defined concentration range where PF4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4c2865ac2ab5ac9fa41b558e892ca5
https://doi.org/10.1089/aid.2015.0344

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Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia

Autor: Bruce S. Sachais, Jillian L. Hinds, Douglas B. Cines, Serge Yarovoi, Stephen P. Watson, Lee I. Garner, John J. Rux, Ann H. Rux

Publikováno v: Blood. 119:5955-5962

Patients with heparin-induced thrombocytopenia (HIT) remain at risk for recurrent thromboembolic complications despite improvements in management. HIT is caused by antibodies that preferentially recognize ultralarge complexes (ULCs) of heparin and pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a6c25f4081dade9f9487832b460ef5
https://doi.org/10.1182/blood-2012-01-406801

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Low-density lipoprotein apheresis reduces platelet factor 4 on the surface of platelets: a possible protective mechanism against heparin-induced thrombocytopenia and thrombosis

Autor: Yvette C. Tanhehco, Ann H. Rux, Bruce S. Sachais

Publikováno v: Transfusion. 51:1022-1029

BACKGROUND: Heparin-induced thrombocytopenia and thrombosis (HITT) is characterized by thrombocytopenia due to the formation of antibodies against heparin : platelet factor 4 (PF4) complexes. Despite the exposure to heparin during treatment and predi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05c7d36a0b0f96bd72774b73f5b90d62
https://doi.org/10.1111/j.1537-2995.2010.02911.x

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The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow

Autor: Bruce S. Sachais, Ping Zhang, X. Long Zheng, Weilan Pan, Ann H. Rux

Publikováno v: Blood. 110:1887-1894

ADAMTS13 cleaves von Willebrand factor (VWF) between Tyr1605 and Met1606 residues at the central A2 subunit. The amino-terminus of ADAMTS13 protease appears to be sufficient to bind and cleave VWF under static and denatured condition. However, the ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e6254f0819a8fcfe41e869f27477a8
https://doi.org/10.1182/blood-2007-04-083329

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Elimination of platelet factor 4 (PF4) from platelets reduces atherosclerosis in C57Bl/6 and apoE-/- mice

Autor: Rader D, Dawicki McKenna Jm, Bruce S. Sachais, Ann H. Rux, Turrentine T, Maria Anna Kowalska

Publikováno v: Thrombosis and Haemostasis. 98:1108-1113

SummaryActivated platelets, which release platelet factor 4 (PF4) are present in patients with atherosclerosis. To date, no direct invivo evidence exists for the involvement of PF4 in atherogenesis. In the current study, we tested the hypothesis that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccb244c22df6933707a9d43e16ac5bee
https://doi.org/10.1160/th07-04-0271

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Function of Herpes Simplex Virus Type 1 gD Mutants with Different Receptor-Binding Affinities in Virus Entry and Fusion

Autor: Sheri L. Hanna, Roselyn J. Eisenberg, Gary H. Cohen, Ann H. Rux, Sharon H. Willis, Richard S. B. Milne

Publikováno v: Journal of Virology. 77:8962-8972

We have studied the receptor-specific function of four linker-insertion mutants of herpes simplex virus type 1 glycoprotein D (gD) representing each of the functional regions of gD. We used biosensor analysis to measure binding of the gD mutants to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd24efbe01be03f1cda54d2ae811f373
https://doi.org/10.1128/jvi.77.16.8962-8972.2003

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