Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ann Griffith"'
Publikováno v:
The Journal of Immunology. 208:107.03-107.03
The thymus is the primary site of T cell generation, and the unique thymic stromal microenvironment directs T cell differentiation, self-tolerance and self-restriction. However, the size of the thymus declines precipitously relatively early in life,
Publikováno v:
The Journal of Immunology. 208:174.19-174.19
T lymphocytes develop in the thymus, where mutually inductive signaling between lymphoid progenitors and thymic stromal cells (TSCs) directs the progenitors along a well-characterized program of differentiation. However, the biology of the TSCs compr
Publikováno v:
The Journal of Immunology. 204:143.2-143.2
Susceptibility to many autoimmune diseases increases with age, however, mechanisms linking aging and susceptibility to autoimmunity remain incompletely understood. One hallmark of the aging immune system is atrophy of the thymus, the primary site of
Autor:
Ann Griffith
Publikováno v:
Adaptive Behavior. 22:381-385
Catalase expression mediates redox regulation of promiscuous gene expression in thymic stromal cells
Autor:
Allison Katherine Hester, Manpreet K Semwal, Xiao Yangming, Sergio Cepeda, Thomas Venables, Ann Griffith
Publikováno v:
The Journal of Immunology. 202:65.16-65.16
The primary site for the development of T lymphocytes is the thymus, where cross-talk between thymic stromal cells (TSCs) and T cell progenitors mediates the development and maintenance of both populations. However, the thymus begins to atrophy relat
Publikováno v:
The Journal of Immunology. 202:65.15-65.15
T lymphocytes develop in the thymus, where mutually inductive signaling between lymphoid progenitors and thymic stromal cells directs the progenitors along a well-characterized program of differentiation. However, the biology of the stromal cells com
Publikováno v:
The Journal of Immunology. 200:103.11-103.11
Cytoablative treatments such as chemotherapy and radiation are commonly used during allogeneic hematopoietic stem cell (HSC) transplants. After cytoablation, T cells must be replaced to generate effective immune responses. Cytoablative therapies dama
Publikováno v:
The Journal of Immunology. 198:54.12-54.12
Autoimmune disease affects approximately 3% of the U.S. population and is the leading cause of death among young and middle-aged women. Susceptibility to autoimmune disease generally increases with age in both sexes; however, mechanisms linking aging
Publikováno v:
The Journal of Immunology. 196:204.22-204.22
Age-associated thymic atrophy results in diminished production of new T lymphocytes and a concomitant decrease in responsiveness to new pathogens and vaccines. In addition to loss of thymic size with age, we have shown that critical stromal functions
Autor:
Kathleen Ann Griffith
Publikováno v:
The Journal of Environment & Development. 2:193-203
The North American Free Trade Agreement (NAFTA) seeks to eliminate trade barriers between the United States, Mexico, and Canada. However, promoting sustainable development has been, and will continue to be, a fundamental part of this process. In Mexi