Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ann F. Gilliat"'
Autor:
Hongyuan Wang, Yuan Zhao, Marina Ezcurra, Alexandre Benedetto, Ann F. Gilliat, Josephine Hellberg, Ziyu Ren, Evgeniy R. Galimov, Trin Athigapanich, Johannes Girstmair, Maximilian J. Telford, Colin T. Dolphin, Zhizhou Zhang, David Gems
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 4, Iss 1, Pp 1-12 (2018)
Aging: Runaway programs are a cause of aging The main cause of disease worldwide is aging, a process long suspected to result from damage accumulation. However, new work from a team led by David Gems at University College London describes a different
Externí odkaz:
https://doaj.org/article/3519f894f35745668a4fd12ca37efb50
Autor:
Yuan Zhao, Ann F. Gilliat, Matthias Ziehm, Mark Turmaine, Hongyuan Wang, Marina Ezcurra, Chenhao Yang, George Phillips, David McBay, William B. Zhang, Linda Partridge, Zachary Pincus, David Gems
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Despite its wide use in ageing research, the contribution of specific age-associated pathologies toC. elegansmortality is not well understood. Here the authors identify two types of death in worms, with either a swollen or a shrunken pharynx, that ar
Externí odkaz:
https://doaj.org/article/71789ec218844f8ab9c0ea0c9fa9e546
Autor:
Alexandre Benedetto, Catherine Au, Maximillian A. Thompson, Adelaide Young, Jennifer M. A. Tullet, Emily Clark, James W. M. Green, Kathrin Schmeisser, David Gems, Ann F. Gilliat
Publikováno v:
Aging Cell
Summary In C. elegans, the skn‐1 gene encodes a transcription factor that resembles mammalian Nrf2 and activates a detoxification response. skn‐1 promotes resistance to oxidative stress (Oxr) and also increases lifespan, and it has been suggested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533024dabd3b82fcb2df1a43b55fd076
https://doi.org/10.1111/acel.12627
https://doi.org/10.1111/acel.12627
Autor:
Alexandra L. Petrache, Alexandre Benedetto, Sophie van Schelt, Yila de la Guardia, Qifeng Zhang, Marina Ezcurra, Shoshana Bar-Nun, Ann F. Gilliat, Eleanor J. Tyler, Michael J.O. Wakelam, Catherine Au, David Gems, Thanet Sornda
Publikováno v:
SSRN Electronic Journal.
Aging (senescence) is characterized by the development of numerous pathologies, some of which limit lifespan. Key to understanding aging is discovery of the mechanisms (etiologies) that cause senescent pathology. In Caenorhabditis elegans a major sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f65ae7efd90b37ba07ead39572b87fb
https://doi.org/10.2139/ssrn.3155672
https://doi.org/10.2139/ssrn.3155672
Autor:
Michael J.O. Wakelam, Eleonor Tyler, Marina Ezcurra, Catherine Au, David Gems, Yila de la Guardia, Ann F. Gilliat, Alexandre Benedetto, Thanet Sornda, Shoshana Bar-Nun, Alexandra L. Petrache, Sophie van Schelt, Qifeng Zhang
Aging (senescence) is characterized by the development of numerous pathologies, some of which limit lifespan. Key to understanding aging is discovery of the mechanisms (etiologies) that cause senescent pathology. InCaenorhabditis elegansa major senes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d362cc87a2db22f55c792762d1a3b3
Autor:
Hongyuan, Wang, Yuan, Zhao, Marina, Ezcurra, Alexandre, Benedetto, Ann F, Gilliat, Josephine, Hellberg, Ziyu, Ren, Evgeniy R, Galimov, Trin, Athigapanich, Johannes, Girstmair, Maximilian J, Telford, Colin T, Dolphin, Zhizhou, Zhang, David, Gems
Publikováno v:
NPJ aging and mechanisms of disease. 4
A long-standing belief is that aging (senescence) is the result of stochastic damage accumulation. Alternatively, senescent pathology may also result from late-life, wild-type gene action (i.e., antagonistic pleiotropy, as argued by Williams) leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59d35763ef8b7c1f95da4a7bec36a77d
https://pubmed.ncbi.nlm.nih.gov/29928508
https://pubmed.ncbi.nlm.nih.gov/29928508
Autor:
Josephine E. E. U. Hellberg, Zhizhou Zhang, Yuan Zhao, Trin Athigapanich, Max J. Telford, Ann F. Gilliat, Johannes Girstmair, Alexandre Benedetto, Marina Ezcurra, David Gems, Hongyuan Wang
Many diseases whose frequency increases with advancing age are caused by aging (senescence), but the mechanisms of senescence remain poorly understood. According to G.C. Williams and M.V. Blagosklonny, a major etiological determinant of senescence is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758179689feccc638e9d62c9b28aa532
Autor:
Yila, de la Guardia, Ann F, Gilliat, Josephine, Hellberg, Peter, Rennert, Filipe, Cabreiro, David, Gems
Publikováno v:
Oncotarget
Aging (senescence) includes causal mechanisms (etiologies) of late-life disease, which remain poorly understood. According to the recently proposed hyperfunction theory, based on the older theory of antagonistic pleiotropy, senescent pathologies can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d3ed2bb97fd3239ad9c3c57c25035b0
https://pubmed.ncbi.nlm.nih.gov/27256978
https://pubmed.ncbi.nlm.nih.gov/27256978
Autor:
Josephine E. E. U. Hellberg, Marina Ezcurra, Catherine Au, Jennifer M. A. Tullet, David Gems, Matthias Ziehm, Nattaphong Rattanavirotkul, Inna Feyst, Irene Papatheodorou, Ann F. Gilliat, Michele Riesen, Janet M. Thornton
Publikováno v:
Europe PubMed Central
Aging (Albany NY)
Scopus-Elsevier
Aging (Albany NY)
Scopus-Elsevier
In C. elegans, increased lifespan in daf‐2 insulin/IGF‐1 receptor mutants is accompanied by up‐regulation of the MDL‐1 Mad basic helix‐loop‐helix leucine zipper transcription factor. Here we describe the role of mdl‐1 in C. elegans germ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1979c1c067de2ccb9207ec85b45a2f8
http://europepmc.org/abstract/med/24531613
http://europepmc.org/abstract/med/24531613