Zobrazeno 1 - 10
of 325
pro vyhledávání: '"Ann F. Chambers"'
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/cdedfa54c7514c11bed4b3671a1dd928
Autor:
Niloufar Zarghami, Donna H. Murrell, Michael D. Jensen, Frederick A. Dick, Ann F. Chambers, Paula J. Foster, Eugene Wong
Publikováno v:
Radiation Oncology, Vol 13, Iss 1, Pp 1-11 (2018)
Abstract Background Brain metastasis is becoming increasingly prevalent in breast cancer due to improved extra-cranial disease control. With emerging availability of modern image-guided radiation platforms, mouse models of brain metastases and small
Externí odkaz:
https://doaj.org/article/fdb6e5473117484daf7628971ef8cbef
Autor:
Bart Kolendowski, Haider Hassan, Milica Krstic, Majdina Isovic, Gobi Thillainadesan, Ann F. Chambers, Alan B. Tuck, Joseph Torchia
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-19 (2018)
Abstract Background The estrogen receptor (ER) is a ligand-dependant transcription factor expressed in many breast cancers and is the target of many endocrine-based cancer therapies. Genome-wide studies have shown that the ER binds to gene-specific e
Externí odkaz:
https://doaj.org/article/0c534c020e9b47d59484461438530b5e
Autor:
Donna H. Murrell, Niloufar Zarghami, Michael D. Jensen, Ann F. Chambers, Eugene Wong, Paula J. Foster
Publikováno v:
Translational Oncology, Vol 9, Iss 3, Pp 219-227 (2016)
INTRODUCTION: The incidence of brain metastasis due to breast cancer is increasing, and prognosis is poor. Treatment is challenging because the blood-brain barrier (BBB) limits efficacy of systemic therapies. In this work, we develop a clinically rel
Externí odkaz:
https://doaj.org/article/e5afc095936942559353c1f4327848a6
Autor:
Ute Jungwirth, Antoinette van Weverwijk, Miriam J. Melake, Ann F. Chambers, Qiong Gao, Marc Fivaz, Clare M. Isacke
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 1 (2018)
Studying the complex mechanisms underlying breast cancer metastasis and therapy response necessitates relevant in vivo models, particularly syngeneic models with an intact immune system. Two syngeneic spontaneously metastatic sublines, D2A1-m1 and D2
Externí odkaz:
https://doaj.org/article/2a562a0101f14b86978b3d9811293f52
Autor:
Donna H. Murrell, Amanda M. Hamilton, Christiane L. Mallett, Robbert van Gorkum, Ann F. Chambers, Paula J. Foster
Publikováno v:
Translational Oncology, Vol 8, Iss 3, Pp 176-184 (2015)
OBJECTIVES: Brain metastases due to breast cancer are increasing, and the prognosis is poor. Lack of effective therapy is attributed to heterogeneity of breast cancers and their resulting metastases, as well as impermeability of the blood–brain bar
Externí odkaz:
https://doaj.org/article/0c2250707af24455b39ae05035aef3a3
Autor:
Hon S. Leong, Amy E. Robertson, Konstantin Stoletov, Sean J. Leith, Curtis A. Chin, Andrew E. Chien, M. Nicole Hague, Amber Ablack, Katia Carmine-Simmen, Victor A. McPherson, Carl O. Postenka, Eva A. Turley, Sara A. Courtneidge, Ann F. Chambers, John D. Lewis
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1558-1570 (2014)
Tumor cell extravasation is a key step during cancer metastasis, yet the precise mechanisms that regulate this dynamic process are unclear. We utilized a high-resolution time-lapse intravital imaging approach to visualize the dynamics of cancer cell
Externí odkaz:
https://doaj.org/article/8c78d3b31e9a449eb0c66822ac1f735e
Publikováno v:
Analytical Cellular Pathology, Vol 20, Iss 4, Pp 163-171 (2000)
Increased amounts of chromatin condensation (i.e., localized areas of high DNA density, or chromatin higher order packing state) have been described in NIH 3T3 cells transformed with the Ha‐ras oncogene. The structural basis for this oncogene‐med
Externí odkaz:
https://doaj.org/article/d3c09e6893f04e758626f5753c169d54
Autor:
Ann F. Chambers, Alison L. Allan, Patricia S. Steeg, Diane Palmieri, Paula J. Foster, Emeline J. Ribot, Carmen Simedrea, Patricia M. McGowan
Brain metastasis from breast cancer is an increasingly important clinical problem. Here we assessed the role of CD44hi/CD24lo cells and pathways that regulate them, in an experimental model of brain metastasis. Notch signaling (mediated by γ-secreta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b77906a52b65078c44ad4c6931eac98
https://doi.org/10.1158/1541-7786.c.6542164
https://doi.org/10.1158/1541-7786.c.6542164
Autor:
Ann F. Chambers, Alison L. Allan, Patricia S. Steeg, Diane Palmieri, Paula J. Foster, Emeline J. Ribot, Carmen Simedrea, Patricia M. McGowan
Supplementary Table 1, Figures 1-4 from Notch1 Inhibition Alters the CD44hi/CD24lo Population and Reduces the Formation of Brain Metastases from Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6c6d99d2610e53b9f91b051b573f24
https://doi.org/10.1158/1541-7786.22518880.v1
https://doi.org/10.1158/1541-7786.22518880.v1