Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ann E Kingston"'
Autor:
David Arons, W. K. Alfred Yung, Ann E Kingston, Samantha A Couillard, Amanda Bates, Patrick Y. Wen, Michael A. Vogelbaum
The National Brain Tumor Society conducted an online survey to determine if, when, and how information about clinical trials is provided to brain tumor patients and their caregivers, as well as to understand the perceptions and barriers around clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef753a54e04547c8b1db76e483362b58
https://europepmc.org/articles/PMC5693067/
https://europepmc.org/articles/PMC5693067/
Autor:
Bryan G. Johnson, David O. Calligaro, Gerard J. Marek, Craig R. Salhoff, James A. Monn, Ce Zhang, Ann E. Kingston, Darryle D. Schoepp, Rebecca A. Wright
Publikováno v:
Neuropharmacology. 66:89-98
Group II metabotropic glutamate (mGlu) receptor agonists were efficacious in randomized clinical research trials for schizophrenia and generalized anxiety disorder. The regional quantification of mGlu(2) and mGlu(3) receptors remains unknown. A selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73d836b0a3fb1f2cecc7f146afbcce84
https://doi.org/10.1016/j.neuropharm.2012.01.019
https://doi.org/10.1016/j.neuropharm.2012.01.019
Publikováno v:
SLAS Discovery. 13:101-111
Amyloid beta (Abeta) peptides are the major constituent of amyloid plaques, one of the hallmark pathologies of Alzheimer's disease. Accurate and precise quantitation of these peptides in biological fluids is a critical component of Alzheimer's diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cafae4ddee2cd21f48a0ccd45f16ee
https://doi.org/10.1177/1087057107312778
https://doi.org/10.1177/1087057107312778
Autor:
Eric S. Nisenbaum, Darryle D. Schoepp, Gerard J. Marek, David L. McKinzie, James A. Monn, Ann E. Kingston, M. Herin, John T. Catlow, Bryan G. Johnson, Jennifer L. Burkey, Deborah D. Giera, Linda M. Rorick-Kehn, Rebecca A. Wright, David O. Calligaro
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:308-317
Group II metabotropic glutamate (mGlu) receptor agonists, including (1 S ,2 S ,5 R ,6 S )-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate monohydrate (LY354740) and (–)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), have demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d401ae47d0c219201523f1eea271445
https://doi.org/10.1124/jpet.106.110809
https://doi.org/10.1124/jpet.106.110809
Autor:
Martin Bendszus, Caroline Chung, W. K. Alfred Yung, Daniel P. Barboriak, Michael V. Knopp, Elizabeth R. Gerstner, Dewen Yang, Evanthia Galanis, Chas Haynes, Bradley J. Erickson, David Arons, Timothy F. Cloughesy, Andrew Whitney, Mark R. Gilbert, Jayashree Kalpathy-Cramer, Paula M. Jacobs, Al Musella, Whitney B. Pope, Gregory V. Goldmacher, Patrick Y. Wen, Sarah J. Nelson, Brian M. Alexander, Marion Smits, Soonme Cha, Jerrold L. Boxerman, David Sandak, Michael A. Vogelbaum, Wolfgang Wick, Benjamin M. Ellingson, Lalitha K. Shankar, Susan M. Chang, Max Wallace, Martin J. van den Bent, Michael Weller, Ann E Kingston
Publikováno v:
Neuro-Oncology, 17(9), 1188-1198. Oxford University Press
A recent joint meeting was held on January 30, 2014, with the US Food and Drug Administration (FDA), National Cancer Institute (NCI), clinical scientists, imaging experts, pharmaceutical and biotech companies, clinical trials cooperative groups, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fcf5c8942bda280fc10cab265b0ed1
https://doi.org/10.1093/neuonc/nov095
https://doi.org/10.1093/neuonc/nov095
Autor:
Sherri L. Andis, Steven S. Henry, Darryle D. Schoepp, Deborah D. Giera, Rebecca A. Wright, and Ann E. Kingston, Marc Herin, Gregory A. Stephenson, Bryan G. Johnson, Steven Marc Massey, John T. Catlow, Mark G. Bures, Matthew John Valli, James A. Monn
Publikováno v:
Journal of Medicinal Chemistry. 50:233-240
(-)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate (LY389795, (-)-3) is a highly potent and selective agonist of metabotropic glutamate receptors 2 (mGlu2) and 3 (mGlu3). As part of our ongoing research program, we have prepared S-oxidized var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ee56b6f2c7ef0b15c22370c0370c5a
https://doi.org/10.1021/jm060917u
https://doi.org/10.1021/jm060917u
Autor:
Ann E. Kingston, Alain Bloc, Andrea Volterra, Chiara F. Valori, Raffaella Capobianco, Paola Bezzi, Giorgio Giaccone, Andrea Crugnola, Liliana Brambilla, Michela Mangieri, Daniela Rossi
Publikováno v:
Journal of Biological Chemistry. 280:42088-42096
The cytokine tumor necrosis factor-alpha (TNFalpha) induces Ca2+-dependent glutamate release from astrocytes via the downstream action of prostaglandin (PG) E2. By this process, astrocytes may participate in intercellular communication and neuromodul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873ea90c8410c0a90a731bdf724e61b1
https://doi.org/10.1074/jbc.m504124200
https://doi.org/10.1074/jbc.m504124200
Publikováno v:
Journal of Biological Chemistry. 280:30469-30480
G-protein-coupled receptors are well known for converting an extracellular signal into an intracellular response. Here we showed that the metabotropic glutamate receptor 5 (mGlu5) plays a dynamic intracellular role in signal transduction. Activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa64f1d9f505d9c7a52700694c24d409
https://doi.org/10.1074/jbc.m501775200
https://doi.org/10.1074/jbc.m501775200
Autor:
Bryan G. Johnson, Joseph P. Tizzano, Michael P. Johnson, Kelly I. Griffey, Darryle D. Schoepp, Rebecca A. Wright, John R. Harris, Gerald Kelly, Ann E. Kingston, Mary Jo Chamberlain, Rosemarie Tomlinson, Barry Peter Clark, Richard S. Baker
Publikováno v:
Neuroscience Letters. 330:127-130
A series of novel group I metabotropic glutamate receptor (mGlu) antagonists have been designed on the basis of the 4-carboxyphenylglycine pharmacophore. The compounds are either mGlu1 receptor selective or equipotent for both mGlu1 and mGlu5 recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cbdd09122fcc04534fbba2a2c6b34a
https://doi.org/10.1016/s0304-3940(02)00751-6
https://doi.org/10.1016/s0304-3940(02)00751-6
Autor:
Juan Félix Espinosa, Ivan Collado, Darryle Darwin Schoepp, Ann E. Kingston, Bryan G. Johnson, Angel Mazon, Concepcion Pedregal, Jaime Blanco-Urgoiti, Rebecca A. Wright
Publikováno v:
Journal of Medicinal Chemistry. 45:3619-3629
The asymmetric synthesis and biological activity of (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine 7 and its epimer at the C3' center 6 are described. Compound 7 is a highly potent and selective agonist for group 2 metabotropric glutama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421e2f7115b6159bb49309d2268aaa27
https://doi.org/10.1021/jm0110486
https://doi.org/10.1021/jm0110486