Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Ann E Jerse"'
Autor:
Rebekah A Jones, Fidel Ramirez-Bencomo, Gail Whiting, Min Fang, Hayley Lavender, Kacper Kurzyp, Angela Thistlethwaite, Lenka Stejskal, Smruti Rashmi, Ann E Jerse, Ana Cehovin, Jeremy P Derrick, Christoph M Tang
Publikováno v:
PLoS Pathogens, Vol 20, Iss 11, p e1012688 (2024)
Gonorrhoea, caused by Neisseria gonorrhoeae, is a common sexually transmitted infection. Increasing multi-drug resistance and the impact of asymptomatic infections on sexual and reproductive health underline the need for an effective gonococcal vacci
Externí odkaz:
https://doaj.org/article/0b6272bd1e784526b32874625ff2ee64
Autor:
Isabelle Leduc, Kristie L Connolly, Afrin Begum, Knashka Underwood, Stephen Darnell, William M Shafer, Jacqueline T Balthazar, Andrew N Macintyre, Gregory D Sempowski, Joseph A Duncan, Marguerite B Little, Nazia Rahman, Eric C Garges, Ann E Jerse
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1008602 (2020)
There is a pressing need for a gonorrhea vaccine due to the high disease burden associated with gonococcal infections globally and the rapid evolution of antibiotic resistance in Neisseria gonorrhoeae (Ng). Current gonorrhea vaccine research is in th
Externí odkaz:
https://doaj.org/article/74a38cc3d9d04837a751e9b443e7f5f5
Publikováno v:
PLoS Pathogens, Vol 15, Iss 3, p e1007385 (2019)
The six-component maintenance of lipid asymmetry (Mla) system is responsible for retrograde transport of phospholipids, ensuring the barrier function of the Gram-negative cell envelope. Located within the outer membrane, MlaA (VacJ) acts as a channel
Externí odkaz:
https://doaj.org/article/14c1fa4f9bab45fc98d6a245e542a0c8
Autor:
Kieran C. Broder, Vera Y. Matrosova, Rok Tkavc, Elena K. Gaidamakova, Lam Thuy Vi Tran Ho, Andrew N. Macintyre, Anthony Soc, Aissata Diallo, Stephen C. Darnell, Sarah Bash, Michael J. Daly, Ann E. Jerse, George W. Liechti
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-17 (2024)
Abstract Chlamydia trachomatis infections are the most common bacterial STIs globally and can lead to serious morbidity if untreated. Development of a killed, whole-cell vaccine has been stymied by coincident epitope destruction during inactivation.
Externí odkaz:
https://doaj.org/article/22af534df9104a818f3712b548f15c5d
Autor:
Ryszard A Zielke, Adriana Le Van, Benjamin I Baarda, Marco F Herrera, Christopher J Acosta, Ann E Jerse, Aleksandra E Sikora
Publikováno v:
PLoS Pathogens, Vol 14, Iss 7, p e1007081 (2018)
Lysozymes are nearly omnipresent as the first line of immune defense against microbes in animals. They exert bactericidal action through antimicrobial peptide activity and peptidoglycan hydrolysis. Gram-negative bacteria developed several weapons to
Externí odkaz:
https://doaj.org/article/ac19f9d4042448a5b91e286e362a1563
Autor:
Jessica G Cole, Ann E Jerse
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8108 (2009)
BACKGROUND:The development of a gonorrhea vaccine is challenged by the lack of correlates of protection. The antigenically variable neisserial opacity (Opa) proteins are expressed during infection and have a semivariable (SV) and highly conserved (4L
Externí odkaz:
https://doaj.org/article/4666f4d5ee224745985d2c18b9c42a58
Autor:
Delia Onorini, Cory Ann Leonard, Regenia Phillips Campbell, Barbara Prähauser, Theresa Pesch, Robert V. Schoborg, Ann E. Jerse, Bernadetta Tarigan, Nicole Borel
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Chlamydia trachomatis and Neisseria gonorrhoeae are the most frequently reported agents of bacterial sexually transmitted disease worldwide. Nonetheless, C. trachomatis/N. gonorrhoeae coinfection remains understudied. C. trachomatis/N. gonor
Externí odkaz:
https://doaj.org/article/1e583d09ebf949daae73f11b57aee6a8
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Lipid-modified cupredoxin azurin (Laz) is involved in electron transport in Neisseria and proposed to act as an electron donor to the surface-displayed nitrite reductase AniA. We identified Laz in Neisseria gonorrhoeae cell envelopes and naturally el
Externí odkaz:
https://doaj.org/article/2666fd5fd9e340b59db1f73888b72900
Autor:
Andrew N. Macintyre, Gregory D. Sempowski, Kristie L. Connolly, Ann E. Jerse, Allison C Costenoble-Caherty, Michelle Pilligua-Lucas, Knashka Underwood, Anthony Soc, Carolina Gomez
Publikováno v:
J Infect Dis
Murine models of Neisseria gonorrhoeae lower reproductive tract infection are valuable systems for studying N. gonorrhoeae adaptation to the female host and immune responses to infection. These models have also accelerated preclinical testing of cand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801d8603052abce3fe40ed9f48d6d4b0
https://doi.org/10.1093/infdis/jiab211
https://doi.org/10.1093/infdis/jiab211
Autor:
Steven Park, Riccardo Russo, Landon Westfall, Riju Shrestha, Matthew Zimmerman, Veronique Dartois, Natalia Kurepina, Barry Kreiswirth, Eric Singleton, Shao-Gang Li, Nisha Mittal, Yong-Mo Ahn, Joseph Bilotta, Kristie L. Connolly, Ann E. Jerse, Joel S. Freundlich, David S. Perlin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
Drug-resistant Neisseria gonorrhoeae is a serious global health concern. New drugs are needed that can overcome existing drug resistance and limit the development of new resistances.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd6b4597b974eb220a0b3a0bde18da71
https://doi.org/10.1128/aac.00414-22
https://doi.org/10.1128/aac.00414-22