Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ann E Herman"'
Autor:
Amit Bar-Or, Gian-Andrea Thanei, Christopher Harp, Corrado Bernasconi, Ulrike Bonati, Anne H. Cross, Saloumeh Fischer, Laura Gaetano, Stephen L. Hauser, Robert Hendricks, Ludwig Kappos, Jens Kuhle, David Leppert, Fabian Model, Annette Sauter, Harold Koendgen, Xiaoming Jia, Ann E. Herman
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104662- (2023)
Summary: Background: Neurofilament light chain (NfL), a neuronal cytoskeletal protein that is released upon neuroaxonal injury, is associated with multiple sclerosis (MS) relapsing activity and has demonstrated some prognostic ability for future rela
Externí odkaz:
https://doaj.org/article/e7ff9f024a2e4966833fd5346456e54f
Autor:
Sarah A. Laurent, Nicolas B. Strauli, Erica L. Eggers, Hao Wu, Brady Michel, Stanislas Demuth, Arumugam Palanichamy, Michael R. Wilson, Marina Sirota, Ryan D. Hernandez, Bruce Anthony Campbell Cree, Ann E. Herman, H.-Christian von Büdingen
Publikováno v:
Neurology(R) neuroimmunology & neuroinflammation, vol 10, iss 4
Background and ObjectivesThe B cell–depleting anti-CD20 antibody ocrelizumab (OCR) effectively reduces MS disease activity and slows disability progression. Given the role of B cells as antigen-presenting cells, the primary goal of this study was t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d137bc000cb458dc2a1baed27d3aec
https://escholarship.org/uc/item/5sp7j7fk
https://escholarship.org/uc/item/5sp7j7fk
Autor:
Cary M. Looney, Nicolas Strauli, Matthew D. Cascino, Hailey Garma, Aaron V. Schroeder, Chikara Takahashi, William O'Gorman, Cherie Green, Ann E. Herman
Publikováno v:
Clinical Immunology. 248:109265
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84900 (2014)
Recent studies indicate that tyrosine kinase inhibitors, including imatinib, can reverse hyperglycemia in non-obese diabetic (NOD) mice, a model of type 1 diabetes (T1D). Imatinib inhibits c-Abl, c-Kit, and PDGFRs. Next-generation tyrosine kinase inh
Externí odkaz:
https://doaj.org/article/f50f648bbb554fa2afae877b171b3b3a
Autor:
Yaiza Diaz-de-Durana, Janet Lau, Deborah Knee, Christophe Filippi, Marco Londei, Peter McNamara, Marc Nasoff, Michael DiDonato, Richard Glynne, Ann E Herman
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78483 (2013)
Type-1 diabetes (T1D) is an autoimmune disease targeting insulin-producing beta cells, resulting in dependence on exogenous insulin. To date, significant efforts have been invested to develop immune-modulatory therapies for T1D treatment. Previously,
Externí odkaz:
https://doaj.org/article/0d4ffcfeb55d4b96aa7d0dfeaed2ab4b
Autor:
Christopher M. Rose, Wendy Sandoval, Ann E Herman, Peter Liu, Kebing Yu, Qingling Li, W. Rodney Mathews, Jennie R. Lill, Veronica G. Anania, Francesco Pingitore
Publikováno v:
Journal of proteome research. 18(3)
Lupus nephritis (LN) is a severe clinical manifestation of systemic lupus erythematosus (SLE) associated with significant morbidity and mortality. Assessment of severity and activity of renal involvement in SLE requires a kidney biopsy, an invasive p
Autor:
Richard Glynne, Bryan Laffitte, Peter McNamara, George Harb, Weidong Wang, V. Deshmukh, Matthew S. Tremblay, Charles Y. Cho, You Qing Zhang, Ann E. Herman, Peter G. Schultz, Jonathan G. Swoboda, Janine E. Baaten, Weijun Shen, Tom Y.-H. Wu, Christophe M. Filippi, Jing Li, Qihui Jin, Anwesh Kamireddy, Xu Wu
Publikováno v:
Journal of the American Chemical Society. 135:1669-1672
The identification of factors that promote β cell proliferation could ultimately move type 1 diabetes treatment away from insulin injection therapy and toward a cure. We have performed high-throughput, cell-based screens using rodent β cell lines t
Autor:
Tim Wiltshire, Markus Warmuth, Christian C. Lee, Rina Barouch-Bentov, Jianwei Che, Yi Liu, Michael Young, Anastasia Velentza, Serge Batalov, Yating Yang, Niusha Ziaee, Ann E. Herman, Sunjun Kim, Michael P. Cooke, Carie Jackson, Manabu Fujimoto, Yong Jia, Luise Sternberg, James Watson, Karsten Sauer, Andrew T. Miller
Publikováno v:
Molecular Cell. 33(1):43-52
The glycine-rich G loop controls ATP binding and phosphate transfer in protein kinases. Here we show that the functions of Src family and Abl protein tyrosine kinases require an electrostatic interaction between oppositely charged amino acids within
Autor:
Luis Brito, Ennio De Gregorio, Susanna Aprea, Samuele Calabrό, Chun Li, Francesco Doro, Sina Bavari, Miller Andrew T, David A. G. Skibinski, Rekha G. Panchal, Donatello Laera, M. Lamine Mbow, Simone Bufali, Ann E. Herman, Ugo D'Oro, Michael P. Cooke, Elaine Tritto, Padma Malyala, Brunella Brunelli, Elisabetta Monaci, Alex Cortez, Gillis R. Otten, Sara Valentini, Travis K. Warren, Christophe M. Filippi, Nicholas Valiante, Yongkai Li, Tom Y.-H. Wu, Bishnu P. Nayak, Manmohan Singh, Elena Caproni, Derek T. O'Hagan
Publikováno v:
Science translational medicine. 6(263)
Adjuvants increase vaccine potency largely by activating innate immunity and promoting inflammation. Limiting the side effects of this inflammation is a major hurdle for adjuvant use in vaccines for humans. It has been difficult to improve on adjuvan
Publikováno v:
The Journal of Experimental Medicine
Foxp3 is required for the generation and activity of CD4+CD25+ regulatory T (T reg) cells, which are important controllers of autoimmunity, including type-1 diabetes. To determine where T reg cells affect the diabetogenic cascade, we crossed the Foxp