FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis.

Autor: Arvind Ponnusamy, Smeeta Sinha, Gareth D Hyde, Samantha J Borland, Rebecca F Taylor, Emma Pond, Heather J Eyre, Colette A Inkson, Andrew Gilmore, Nick Ashton, Philip A Kalra, Ann E Canfield

Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0196232 (2018)

BackgroundVascular calcification is associated with increased cardiovascular morbidity and mortality in patients with atherosclerosis, diabetes and chronic kidney disease. However, no viable treatments for this condition have been identified. This st

Externí odkaz: https://doaj.org/article/4eec9e79afd54753ab08a2d46520f6c7

Loss of PKCα increases arterial medial calcification in a uremic mouse model of chronic kidney disease

Autor: Neil E. Humphreys, Keith Brennan, Philip J. Withers, Cecilia Facchi, Antony Adamson, Michael J. Sherratt, Sheila E. Francis, Julia Behnsen, Nick Ashton, Samantha Borland, Ann E. Canfield

Arterial medial calcification is an independent risk factor for mortality in chronic kidney disease. We previously reported that knock-down of PKCα expression increases high phosphate-induced mineral deposition by vascular smooth muscle cellsin vitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fdfabb8fed1f53fc3f41b3f2fd884bd
https://doi.org/10.1101/2020.05.20.097642

BS61 PKCαα knock-down enhances intimal calcification in a murine model of atherosclerosis

Autor: Cathy M. Holt, Sheila E. Francis, Julia Behnsen, Keith Brennan, Michael J. Sherratt, Ann E. Canfield, Samantha Borland, Abimbola Akerele

Publikováno v: Basic Science.

Intimal calcification is the formation of mineralised tissue within atherosclerotic lesions and can lead to an increased risk of plaque rupture and mortality in man. Even though experimental data are sparse, it had been suggested that inhibiting prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ded31ca5e86a22fafefa381ed2e8552d
https://doi.org/10.1136/heartjnl-2019-bcs.221

HGF/c-Met signalling promotes Notch3 activation and human vascular smooth muscle cell osteogenic differentiation in vitro

Autor: M. Yvonne Alexander, Ann E. Canfield, Tao Wang, Yiwen Liu, Naomi Jiagbogu, Jianyun Yan, Daniëlle A M Heideman

Publikováno v: Atherosclerosis
Liu, Y, Wang, T, Yang, J, Jiagbogu, N, Heideman, D A M, Canfield, A E & Alexander, M Y 2011, ' HGF/c-Met signalling promotes Notch3 activation and human vascular smooth muscle cell osteogenic differentiation in vitro ', Atherosclerosis, vol. 219, no. 2, pp. 440-447 . https://doi.org/10.1016/j.atherosclerosis.2011.08.033
Atherosclerosis, 219(2), 440-447. Elsevier Ireland Ltd

Objectives Vascular calcification is a major clinical problem and elucidating the underlying mechanism is important to improve the prognosis of patients with cardiovascular disease. We aimed to elucidate the role and mechanism of action of Hepatocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f194397c588b19e2ef05911f86b37b9
https://doi.org/10.1016/j.atherosclerosis.2011.08.033

Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis

Autor: C. Adrian Shuttleworth, Sanjay Sinha, Ann E. Canfield, Cay M. Kielty, Anthony M. Heagerty

Publikováno v: International Journal of Experimental Pathology. 82:295-302

Type VIII collagen is upregulated after vessel injury, and this collagen has been implicated in both smooth muscle cell migration and angiogenesis. This study examines the temporal and spatial pattern of expression of type VIII collagen in porcine co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca2d3d91809393422d5f9be51284631b
https://doi.org/10.1046/j.1365-2613.2001.00201.x