Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Ann E, Tollefson"'
Autor:
Ann E. Tollefson, Anna Cline-Smith, Jacqueline F. Spencer, Baoling Ying, Dawn M. Reyna, Elke Lipka, Scott H. James, Karoly Toth
Publikováno v:
Viruses, Vol 16, Iss 8, p 1200 (2024)
Adenovirus infections of immunocompromised patients can cause life-threatening disseminated disease. While there are presently no drugs specifically approved to treat these infections, there are several compounds that showed efficacy against adenovir
Externí odkaz:
https://doaj.org/article/d809e80032e04f6e8c278c9bdd7ade6a
Autor:
J. Milburn Jessup, Mohamed Kabbout, Nikolay Korokhov, Alex Joun, Ann E. Tollefson, William S. M. Wold, Abid R. Mattoo
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 3, Pp 636-644 (2020)
Treatments with cytotoxic agents or viruses may cause Immunogenic Cell Death (ICD) that immunize tumor-bearing hosts but do not cause complete regression of tumor. We postulate that combining two ICD inducers may cause durable regression in immunocom
Externí odkaz:
https://doaj.org/article/7622a97b8b444b8e842a4c3dfe239e59
Autor:
Rong Li, Baoling Ying, Yanan Liu, Jacqueline F. Spencer, Jinxin Miao, Ann E. Tollefson, James D. Brien, Yaohe Wang, William S. M. Wold, Zhongde Wang, Karoly Toth
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 8 (2020)
Model animals are indispensable for the study of human diseases, and in general, of complex biological processes. The Syrian hamster is an important model animal for infectious diseases, behavioral science and metabolic science, for which more experi
Externí odkaz:
https://doaj.org/article/611314544fa547a78f2bb3a67999d999
Autor:
Shenghua Gao, Letian Song, Tobias Claff, Molly Woodson, Katharina Sylvester, Lanlan Jing, Renato H. Weiße, Yusen Cheng, Norbert Sträter, Laura Schäkel, Michael Gütschow, Bing Ye, Mianling Yang, Tao Zhang, Dongwei Kang, Karoly Toth, John Tavis, Ann E. Tollefson, Christa E. Müller, Peng Zhan, Xinyong Liu
Publikováno v:
Journal of Medicinal Chemistry. 65:16902-16917
The spread of SARS-CoV-2 keeps threatening human life and health, and small-molecule antivirals are in demand. The main protease (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271ca8882f9f7b9c5ad53b93c3b5bbee
https://doi.org/10.1021/acs.jmedchem.2c01716
https://doi.org/10.1021/acs.jmedchem.2c01716
Autor:
Katrin Schaar, Anja Geisler, Milena Kraus, Sandra Pinkert, Markian Pryshliak, Jacqueline F. Spencer, Ann E. Tollefson, Baoling Ying, Jens Kurreck, William S. Wold, Robert Klopfleisch, Karoly Toth, Henry Fechner
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss , Pp 300-316 (2017)
Infections of immunocompromised patients with human adenoviruses (hAd) can develop into life-threatening conditions, whereas drugs with anti-adenoviral efficiency are not clinically approved and have limited efficacy. Small double-stranded RNAs that
Externí odkaz:
https://doaj.org/article/e97e24c9cc81475f96113129d27f1781
Autor:
Karoly Toth, Baoling Ying, Ann E. Tollefson, Jacqueline F. Spencer, Lata Balakrishnan, John E. Sagartz, Robert Mark L. Buller, William S. M. Wold
Publikováno v:
Viruses, Vol 7, Iss 3, Pp 1409-1428 (2015)
Adenovirus infections of immunocompromised pediatric hematopoietic stem cell transplant patients can develop into serious and often deadly multi-organ disease. There are no drugs approved for adenovirus infections. Cidofovir (an analog of 2-deoxycyti
Externí odkaz:
https://doaj.org/article/50ff05ddc4ce4937b99930b25d086754
Autor:
Elke Lipka, Aaron M. Chadderdon, Cheryl C. Harteg, Matthew K. Doherty, Eric S. Simon, John M. Domagala, Dawn M. Reyna, Kim M. Hutchings, Xinmin Gan, Andrew D. White, Caroll B. Hartline, Emma A. Harden, Kathy A. Keith, Mark N. Prichard, Scott H. James, Rhonda D. Cardin, David I. Bernstein, Jacqueline F. Spencer, Ann E. Tollefson, William S. M. Wold, Karoly Toth
Publikováno v:
Molecular pharmaceutics. 20(1)
DNA viruses are responsible for many diseases in humans. Current treatments are often limited by toxicity, as in the case of cidofovir (CDV, Vistide), a compound used against cytomegalovirus (CMV) and adenovirus (AdV) infections. CDV is a polar molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b560c5d392d9bace6b395fe7f5302d
https://pubmed.ncbi.nlm.nih.gov/36484496
https://pubmed.ncbi.nlm.nih.gov/36484496
Autor:
Shenghua Gao, Katharina Sylvester, Letian Song, Tobias Claff, Lanlan Jing, Molly Woodson, Renato H. Weiße, Yusen Cheng, Laura Schäkel, Marvin Petry, Michael Gütschow, Anke C. Schiedel, Norbert Sträter, Dongwei Kang, Shujing Xu, Karoly Toth, John Tavis, Ann E. Tollefson, Christa E. Müller, Xinyong Liu, Peng Zhan
Publikováno v:
Journal of medicinal chemistry. 65(19)
The continuous spread of SARS-CoV-2 calls for more direct-acting antiviral agents to combat the highly infectious variants. The main protease (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f21c7153a2aaab01947dfa7685024a7
https://pubmed.ncbi.nlm.nih.gov/36107752
https://pubmed.ncbi.nlm.nih.gov/36107752
Autor:
Karoly Toth, Sang R Lee, Baoling Ying, Jacqueline F Spencer, Ann E Tollefson, John E Sagartz, Il-Keun Kong, Zhongde Wang, William S M Wold
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005392 (2016)
[This corrects the article DOI: 10.1371/journal.ppat.1005084.].
Externí odkaz:
https://doaj.org/article/7a88433d5c884e0eab016fe4b5b891aa
Autor:
Karoly Toth, Sang R Lee, Baoling Ying, Jacqueline F Spencer, Ann E Tollefson, John E Sagartz, Il-Keun Kong, Zhongde Wang, William S M Wold
Publikováno v:
PLoS Pathogens, Vol 11, Iss 8, p e1005084 (2015)
Human adenoviruses have been studied extensively in cell culture and have been a model for studies in molecular, cellular, and medical biology. However, much less is known about adenovirus replication and pathogenesis in vivo in a permissive host bec
Externí odkaz:
https://doaj.org/article/d6ff951ccb074add9e444fdee9313ac4