Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Ann E, Kingsbury"'
Autor:
Rina Bandopadhyay, Ann E. Kingsbury, Miratul M. Muqit, Kirsten Harvey, Andrew R. Reid, Linda Kilford, Simone Engelender, Michael G. Schlossmacher, Nicholas W. Wood, David S. Latchman, Robert J. Harvey, Andrew J. Lees
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 401-411 (2005)
Lewy bodies (LBs) are the characteristic inclusions of Parkinson's disease brain but the mechanism responsible for their formation is obscure. Lewy bodies (LBs) are composed of a number of proteins of which alpha-synuclein (α-SYN) is a major constit
Externí odkaz:
https://doaj.org/article/6f0ed25c8e0f4630918b13e818439830
Autor:
Ann E. Kingsbury, Janice L. Holton, Alan E. Renton, Sean S. O'Sullivan, Carles Vilariño-Güell, Nicholas W. Wood, Simone Sharma, Tamas Revesz, R. Kumaran, Rina Bandopadhyay, Tammaryn Lashley, Andrew J. Lees, Constantinos Kallis
Publikováno v:
Neuropathology and Applied Neurobiology. 37:777-790
Aims: Mutations in the gene encoding leucine-rich repeat kinase-2 (LRRK2) have been established as a common genetic cause of Parkinson's disease (PD). The distribution of LRRK2 mRNA and protein in the human brain has previously been described, althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cfbe53d74a6358f23be1709a270aec7
https://doi.org/10.1111/j.1365-2990.2011.01187.x
https://doi.org/10.1111/j.1365-2990.2011.01187.x
Autor:
Rina Bandopadhyay, Laura Silveira-Moriyama, Constantinos Kallis, Ann E. Kingsbury, Andrew J. Lees, William Sterlacci, Werner Poewe, Hans Maeir, H Ayling
Publikováno v:
Movement Disorders. 25:2508-2515
The lower brain stem of 25 pathologically-confirmed Parkinson's disease (PD) cases was examined by alpha synuclein immunohistochemistry to characterize pathological accumulation of alpha synuclein (Lewy-type α-synucleinopathy, LTS) in the medulla ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45a0635aabf1d32184603d4b0cc56081
https://doi.org/10.1002/mds.23305
https://doi.org/10.1002/mds.23305
Autor:
David J. Burn, David R. Williams, Janice L. Holton, Huw R. Morris, Graham Hughes, Andrew J. Lees, Ann E. Kingsbury, Aviva Petrie, H Ayling, Alistair Church, Tamas Revesz, Laura Silveira-Moriyama
Publikováno v:
Movement Disorders. 25:570-577
Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c860758db9ebdb446a1ecf47f6244a24
https://doi.org/10.1002/mds.22688
https://doi.org/10.1002/mds.22688
Publikováno v:
European Journal of Pharmacology. 604:45-50
We have recently observed that the corticotrophin releasing factor (CRF) related peptide urocortin reverses key features of nigrostriatal damage in two paradigms of Parkinson's disease. Here we have studied whether these effects are supported by a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d1abf1cebccc37208416e8eb619763
https://doi.org/10.1016/j.ejphar.2008.11.009
https://doi.org/10.1016/j.ejphar.2008.11.009
Autor:
Nicholas W. Wood, Cristina Sampaio, Vincenzo Bonifati, Leonor Correia Guedes, Egberto Reis Barbosa, Aviva Petrie, Joaquim J. Ferreira, Karen Shaw, Tamas Revesz, Ann E. Kingsbury, Patrick M. Abou-Sleiman, Janice L. Holton, H Ayling, Laura Silveira-Moriyama, Niall Quinn, Andrew J. Lees
Publikováno v:
Neurology, 71(13), 1021-1026. Lippincott Williams & Wilkins
Background: Mutations in PARK8 (LRRK2) are associated with autosomal dominant parkinsonism and Parkinson disease (PD). Hyposmia is present in at least 80% of patients with PD and an accumulation of alpha-synuclein (alpha-syn) is seen in the olfactory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c212095babae99fd5f249e81bc16a7f9
https://doi.org/10.1212/01.wnl.0000326575.20829.45
https://doi.org/10.1212/01.wnl.0000326575.20829.45
Autor:
Andrew J. Lees, Rohan de Silva, David M. A. Mann, David R. Williams, Ravindran Kumaran, Ian C. Coulter, Rina Bandopadhyay, Tamas Revesz, Tammaryn Lashley, Ann E. Kingsbury
Publikováno v:
Neurobiology of Disease, Vol 28, Iss 1, Pp 122-132 (2007)
Mutations in the DJ-1 gene are associated with autosomal recessive Parkinson's disease (PD), but its role in disease pathogenesis is unknown. This study examines DJ-1 immunoreactivity (DJ-1 IR) in a variety of neurodegenerative disorders, Alzheimer's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0178eed9fe1506773511c5202fdaf34d
https://doi.org/10.1016/j.nbd.2007.07.012
https://doi.org/10.1016/j.nbd.2007.07.012
Autor:
Andrew J. Lees, Ann E. Kingsbury, Amjad Abuirmeileh, Hardial S. Chowdrey, Ian C. Locke, Richard A. Knight, Rebecca Lever, Peter S. Whitton, Christopher S. Biggs
Publikováno v:
European Journal of Neuroscience. 26:417-423
The potential neuroprotective action of the corticotrophin-releasing factor-related peptide urocortin (UCN) was investigated in the rat 6-hydroxydopamine (6-OHDA) and lipopolysaccharide (LPS) paradigms of Parkinson's disease. UCN (20 fmol) was either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0fb9b9af3f49b75d5400f25cf591c78
https://doi.org/10.1111/j.1460-9568.2007.05653.x
https://doi.org/10.1111/j.1460-9568.2007.05653.x
Autor:
Alice Kaganovich, Elisa Greggio, Andrew J. Lees, Jeff Blackinton, Alexandra Beilina, Robert J. Harvey, Kirsten Harvey, Sashi Kesavapany, Rina Bandopadhyay, Andrew B. Singleton, Ann E. Kingsbury, Kelly Jean Thomas, David Miller, Patrick A. Lewis, Mark R. Cookson, Shushant Jain, Rili Ahmad, Marcel P. van der Brug
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 2, Pp 329-341 (2006)
Mutations in the LRRK2 gene, coding for dardarin, cause dominantly inherited Parkinson's disease (PD). Dardarin is a large protein, and mutations are found throughout the gene including the kinase domain. However, it is not clear if kinase activity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1746147630676cc924458324ecac07
http://www.sciencedirect.com/science/article/pii/S0969996106000714
http://www.sciencedirect.com/science/article/pii/S0969996106000714
Publikováno v:
Movement Disorders. 21:2208-2211
Increased numbers of dopaminergic neurons are described in the striatum of patients with Parkinson's disease. In postmortem striatal tissue from Parkinson's disease patients with short disease duration (≤8 years), the number of dopaminergic neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc405ccec1c63e3790d5a2b361a6c9d
https://doi.org/10.1002/mds.21129
https://doi.org/10.1002/mds.21129