Spatial distribution of active compounds in stratum corneum—partitioning between corneocytes and lipid matrix

Autor: Peter Sjövall, Sebastien Gregoire, William Wargniez, Lisa Skedung, Ann Detroyer, Gustavo S. Luengo

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract The interaction of active substances with molecular structures in stratum corneum (SC) is crucial for the efficacy and safety of cosmetic formulations and topical drugs. However, the molecular architecture of SC is highly complex and methods

Externí odkaz: https://doaj.org/article/a2b814aba2864dcaa97e94c3e1650252

Screening Ionic Solvents for Enhancing the Solubility of Water-Insoluble Natural Dyes

Autor: Luiz Fernando Lepre, Stephane Sabelle, Agilio A. H. Padua, Margarida F. Costa Gomes, Marie-Céline Frantz, Floriane Beaumard, Ann Detroyer

Publikováno v: Industrial and engineering chemistry research
Industrial and engineering chemistry research, American Chemical Society, 2021, 60 (23), pp.8555-8564. ⟨10.1021/acs.iecr.1c00785⟩
Industrial and engineering chemistry research, 2021, 60 (23), pp.8555-8564. ⟨10.1021/acs.iecr.1c00785⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50be16693c8b1c6cd92f6d2369ab073c
https://hal.archives-ouvertes.fr/hal-03365734

Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment - A case study with parabens

Autor: Gladys Ouedraogo, Camilla Alexander-White, Dagmar Bury, Harvey J. Clewell, Mark Cronin, Tom Cull, Matthew Dent, Bertrand Desprez, Ann Detroyer, Corie Ellison, Stefania Giammanco, Eric Hack, Nicola J. Hewitt, Gerry Kenna, Martina Klaric, Reinhard Kreiling, Cathy Lester, Catherine Mahony, Enrico Mombelli, Jorge Naciff, John O'Brien, Andreas Schepky, Sarah Tozer, Bart van der Burg, Barbara van Vugt-Lussenburg, Sharon Stuard, null Cosmetics Europe

Publikováno v: Regulatory toxicology and pharmacology : RTP. 132

Parabens are esters of para-hydroxybenzoic acid that have been used as preservatives in many types of products for decades including agrochemicals, pharmaceuticals, food and cosmetics. This illustrative case study with propylparaben (PP) demonstrates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4309dbeaf4d25867d81982bd4812f818
https://pubmed.ncbi.nlm.nih.gov/35508214

An atomistic model of the human stratum corneum: permeation through the long periodicity phase—effect of a pro-penetrant

Autor: Christian Jorgensen, Fabien Léonforte, Gustavo. S. Luengo, Sébastien Gregoire, Bruno Biatry, Peter D. Olmsted, Ann Detroyer

Publikováno v: Biophysical Journal. 121:35a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1037425db53c5d56550d8e5a70daeb84
https://doi.org/10.1016/j.bpj.2021.11.2544

Accounting for data variability, a key factor inin vivo/in vitrorelationships: application to the skin sensitization potency (in vivoLLNA versusin vitroDPRA) example

Autor: Ovanes G. Mekenyan, Stephanie Ringeissen, Chanita Kuseva, Joan Eilstein, I. Popova, Thierry Pauloin, S. Dimitrov, Yordan H. Karakolev, Ann Detroyer, Hristiana Ivanova, C. Piroird, Charles Gomes

Publikováno v: Journal of Applied Toxicology. 36:1568-1578

When searching for alternative methods to animal testing, confidently rescaling an in vitro result to the corresponding in vivo classification is still a challenging problem. Although one of the most important factors affecting good correlation is sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2556c7c842aa29c0c3b57617c1f446ca
https://doi.org/10.1002/jat.3318