Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Ann Dean"'
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114378- (2024)
Summary: The Myb proto-oncogene encodes the transcription factor c-MYB, which is critical for hematopoiesis. Distant enhancers of Myb form a hub of interactions with the Myb promoter. We identified a long non-coding RNA (Myrlin) originating from the
Externí odkaz:
https://doaj.org/article/512633a1430a496fac90bc4c3529afec
Autor:
Christopher B. Chambers, Jeffrey Gross, Katherine Pratt, Xiang Guo, Colleen Byrnes, Y. Terry Lee, Donald Lavelle, Ann Dean, Jeffery L. Miller, Andrew Wilber
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 429-440 (2020)
Sickle cell disease (SCD) and β-thalassemia are caused by structural abnormality or inadequate production of adult hemoglobin (HbA, α2β2), respectively. Individuals with either disorder are asymptomatic before birth because fetal hemoglobin (HbF,
Externí odkaz:
https://doaj.org/article/0d5bb54e54684290a29829b79c64d624
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-3 (2018)
Abstract A recent study used CRISPR/Cas9 to reveal long-range looping between disease-related genes and their regulatory elements that is mediated by the CCCTC-binding factor (CTCF) in prostate cancer.
Externí odkaz:
https://doaj.org/article/4afbbb3aa87341a5bd9f5a4fff7fd309
Publikováno v:
Cell Reports, Vol 19, Iss 12, Pp 2490-2502 (2017)
Summary: Lineage-specific transcription factors are critical for long-range enhancer interactions, but direct or indirect contributions of architectural proteins such as CCCTC-binding factor (CTCF) to enhancer function remain less clear. The LDB1 com
Externí odkaz:
https://doaj.org/article/f88af27a09f545d197ef2ef7fb033d52
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0281976 (2023)
Numerous intervention studies have attempted to increase cervical screening uptake among immigrant women, nonetheless their screening participation remains low. This systematic review and meta-analysis aimed to summarise the evidence on interventions
Externí odkaz:
https://doaj.org/article/ab6c8a3f03e04b44a2a7503d0e00417b
Publikováno v:
Women's Health, Vol 18 (2022)
Introduction: Cervical cancer remains a major cause of morbidity and mortality among women from low and lower middle-income countries, as well as underserved population subgroups in high-income countries. Migration from South Asia to Australia has in
Externí odkaz:
https://doaj.org/article/8c7653cdbd9a4ca788b8d0802ac9b4a5
Autor:
Ann Dean, Juhyun Kim
Publikováno v:
Current Opinion in Structural Biology. 71:101-109
The activity and selectivity of transcriptional enhancers determine gene expression patterns that enable a zygote to become a complex organism. How enhancers convey regulatory information is a central conundrum in biology. Here, we discuss recent pro
Publikováno v:
Nucleic Acids Res
Enhancers establish proximity with distant target genes to regulate temporospatial gene expression and specify cell identity. Lim domain binding protein 1 (LDB1) is a conserved and widely expressed protein that functions as an enhancer looping factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c32c24d7879d6957ba8c02c0b096806
https://europepmc.org/articles/PMC9458430/
https://europepmc.org/articles/PMC9458430/
Publikováno v:
Nucleic Acids Res
The underlying mechanism of transcriptional co-repressor ETO2 during early erythropoiesis and hemoglobin switching is unclear. We find that absence of ETO2 in mice interferes with down-regulation of PU.1 and GATA2 in the fetal liver, impeding a key s
Publikováno v:
Transplant Psychiatry ISBN: 9783031150517
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d7d09972971f7ea88282f9f458d2655
https://doi.org/10.1007/978-3-031-15052-4_11
https://doi.org/10.1007/978-3-031-15052-4_11