Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ann D. Mitrovic"'
Publikováno v:
Ticks and Tick-borne Diseases. 9:471-478
Babesia and Theileria are intraerythrocytic protozoans of the phylum Apicomplexa. These species are capable of infecting wild and domestic animals and have historically caused great economic loss in the agricultural industry. In recent years human ba
Autor:
Florian M. Gebhardt, Peter R. Dodd, Ann D. Mitrovic, Joseph W. Lynch, Daniel Gilbert, Robert J. Vandenberg
Publikováno v:
Journal of Biological Chemistry. 285:31313-31324
The glial transporter excitatory amino acid transporter-2 (EAAT2) is the main mediator of glutamate clearance in brain. The wild-type transporter (EAAT2wt) forms trimeric membrane complexes in which each protomer functions autonomously. Several EAAT2
Publikováno v:
European Journal of Pharmaceutical Sciences. 23:1-11
The regulation of glutamate and glycine concentrations within excitatory synapses plays an important role in maintaining a dynamic signalling process between neurones, but the failure to regulate the concentrations of these neurotransmitters has been
Autor:
Robert J. Vandenberg, Tanya Provis, Charbel El-Hajj Moussa, Ann D. Mitrovic, William A. Bubb, Vladimir J. Balcar, Caroline Rae
Publikováno v:
Neurochemical Research. 27:27-35
(2S,1'S,2'R)-2-(Carboxycyclopropyl)glycine (L-CCG III) was a substrate of Na+-dependent glutamate transporters (GluT) in Xenopus laevis oocytes (IC50 ∼ 13 and ∼2 μM for, respectively, EAAT 1 and EAAT 2) and caused an apparent inhibition of [3H]L
Publikováno v:
Journal of Biological Chemistry. 276:26071-26076
Glutamate transport by the excitatory amino acid transporters (EAATs) is coupled to the co-transport of 3 Na(+) ions and 1 H(+) and the counter-transport of 1 K(+) ion, which ensures that extracellular glutamate concentrations are maintained in the s
Autor:
Graham A.R. Johnston, Ann D. Mitrovic, Rujee K. Duke, Kenneth N. Mewett, Mary Chebib, Robert J. Vandenberg
Publikováno v:
Drug Development Research. 46:255-260
GABA and glutamate are the major inhibitory and excitatory neurotransmitters, respec- tively, in the human brain. Many GABA and glutamate receptors and transporters are key protein targets for drug development, and many known CNS drugs act on these t
Publikováno v:
Neurochemistry International. 34:101-108
Oestrous cycle and sex differences in sodium-dependent transport of L-[3H]glutamate and L-[3H]aspartate were investigated employing well washed synaptosomes prepared from rat brain cortex. Transport was best analysed on the basis of two components, a
Publikováno v:
Molecular Pharmacology. 54:189-196
Zinc ions (Zn2+) are stored in synaptic vesicles with glutamate in a number of regions of the brain. When released into the synapse, Zn2+ modulates the activity of various receptors and ion channels. Excitatory amino acid transporters (EAATs) maintai
Publikováno v:
Journal of Biological Chemistry. 273:14698-14706
Glutamate transporters serve the important function of mediating removal of glutamate released at excitatory synapses and maintaining extracellular concentrations below excitotoxic levels. Excitatory amino acid transporter subtypes EAAT1 and EAAT2 ha
Publikováno v:
British Journal of Pharmacology. 123:1593-1600
1. Expression of the recombinant human excitatory amino aid transporters, EAAT1 and EAAT2, in Xenopus laevis oocytes allows electrogenic transport to be studied under voltage clamp conditions. 2. We have investigated the transport of the pharmacologi