Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ann D. Dunn"'
Autor:
John T. Dunn, Ann D. Dunn
Publikováno v:
Thyroid. 11:407-414
The thyroid concentrates iodide from the serum and oxidizes it at the apical membrane, attaching it to tyrosyl residues within thyroglobulin (Tg) to make diiodotyrosine and monoiodotyrosine. Major players in this process are Tg, thyroperoxidase (TPO)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa821b4e9ed70f02492528583bcc160
https://doi.org/10.1089/105072501300176363
https://doi.org/10.1089/105072501300176363
Autor:
Ann D. Dunn, John T. Dunn
Publikováno v:
Biochimie. 81:505-509
Thyroglobulin (Tg) is the most important protein in the thyroid because it provides the matrix for thyroid hormone biosynthesis. Here we review experimental work, principally from our laboratory, on the relationship between Tg structure and hormonoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad2a62af0a9f373eb16fd743acd88541
https://doi.org/10.1016/s0300-9084(99)80102-3
https://doi.org/10.1016/s0300-9084(99)80102-3
Publikováno v:
Thyroid. 3:119-123
Urinary iodine excretion is currently the most convenient laboratory marker of iodine deficiency. Accelerating international interest in correcting this condition demands rapid, simple methods for assessment and monitoring. We describe two adaptation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafce098afe405cd8c3f754ce4a0cc0f
https://doi.org/10.1089/thy.1993.3.119
https://doi.org/10.1089/thy.1993.3.119
Publikováno v:
Journal of Biological Chemistry. 266:20198-20204
The normal provision of thyroid hormones to the body requires their release from the prohormone, thyroglobulin (Tg). Previous work established the importance of cathepsins B, D, and L (formerly designated cysteine proteinase I) to this process but ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94dad0497376808aa364b880db114423
https://doi.org/10.1016/s0021-9258(18)54909-7
https://doi.org/10.1016/s0021-9258(18)54909-7
Autor:
Francois Delange, Françoise Vertongen, Samar Chaker, Daniella Gnat, Ann D. Dunn, John T. Dunn
Publikováno v:
Clinical chemistry. 49(1)
International groups recommend the following median urinary iodine concentration as the best single indicator of iodine nutrition in populations: severe deficiency, 0–0.15 μmol/L (0–19 μg/L); moderate deficiency, 0.16–0.38 μmol/L (20–49 μ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4fa69fe3f74a7c0f213c9a7e335e37
https://pubmed.ncbi.nlm.nih.gov/12507981
https://pubmed.ncbi.nlm.nih.gov/12507981
Autor:
Armando E. Fraire, Ashraf Khan, Peter H. Simkin, Susan A. Afonso, Ann D. Dunn, Lewis E. Braverman, John T. Dunn, Luis A. Ramirez, Susan Zweizig
Publikováno v:
Thyroid : official journal of the American Thyroid Association. 9(9)
A case of low thyroid radioactive iodine uptake (RAIU) thyrotoxicosis due to a large struma ovarii comprising pure thyroid tissue is presented, including a detailed diagnostic evaluation, histopathology, and demonstration of rapid recovery of native
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a008fa4d24192d62e6eecf9197a7ae
https://pubmed.ncbi.nlm.nih.gov/10524575
https://pubmed.ncbi.nlm.nih.gov/10524575
Publikováno v:
Thyroid : official journal of the American Thyroid Association. 9(8)
Oral tolerization with the appropriate antigen(s) to ameliorate autoimmune diseases in humans and in experimentally induced animal models, including experimentally autoimmune thyroiditis in mice, has been reported to be efficacious. Spontaneous and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39db736617755910bbc98976cfc352ec
https://pubmed.ncbi.nlm.nih.gov/10482377
https://pubmed.ncbi.nlm.nih.gov/10482377
Publikováno v:
The Journal of biological chemistry. 273(39)
The thyroid couples two iodotyrosine molecules to produce thyroid hormone at the acceptor site in thyroglobulin, leaving dehydroalanine or pyruvate at the donor position. Previous work has located the acceptors but not the principal iodotyrosine dono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf903c9d0310514a98b9b9878d57212
https://pubmed.ncbi.nlm.nih.gov/9737985
https://pubmed.ncbi.nlm.nih.gov/9737985
Publikováno v:
Endocrinology. 137(8)
Thyroid hormones are synthesized within the thyroglobulin (Tg) molecule and must be released to reach the circulation and exert their metabolic effect. We have previously shown that three lysosomal endopeptidases, cathepsin B, D, and L, are active in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c538eb35523841f4adea63dff5edb5
https://pubmed.ncbi.nlm.nih.gov/8754751
https://pubmed.ncbi.nlm.nih.gov/8754751
Autor:
Margaret A. Shupnik, J Wortsman, Helen E. Myers, S J Hoback, John T. Dunn, K H Day, R N Day, Ann D. Dunn, M E Mason
Publikováno v:
The Journal of clinical endocrinology and metabolism. 80(2)
We studied thyroid tissue from two siblings with Pendred's syndrome (familial goiter and congenital deafness), both with the Mondini-type inner ear malformation, goiter, and hypothyroidism. Iodine trapping and peroxidase levels were grossly normal. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab213e7b042d426d5817bcb0962ef7ed
https://pubmed.ncbi.nlm.nih.gov/7852510
https://pubmed.ncbi.nlm.nih.gov/7852510