Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Ann Christin Beck"'
Autor:
Andreas Unterberg, Hartmut Rehwinkel, Ann Christin Beck, Felix Sahm, Michael Platten, Daniel Schrimpf, Stefan Kaulfuss, Wolfgang Wick, Olaf Panknin, Holger Hess-Stumpp, Roland Neuhaus, Roman C. Hillig, Judith Guenther, David Capper, Andrea Haegebart, Luisella Toschi, Markus Bauser, Stefan Pusch, Manfred Jugold, Martina Ott, Christel Herold-Mende, Katja Zimmermann, Jörg Balss, Jessica Eisel, Sonja Krausert, Viktoria Eichwald, Viktoria Fischer, Andreas von Deimling
Publikováno v:
Acta Neuropathologica. 133:629-644
Mutations in codon 132 of isocitrate dehydrogenase (IDH) 1 are frequent in diffuse glioma, acute myeloid leukemia, chondrosarcoma and intrahepatic cholangiocarcinoma. These mutations result in a neomorphic enzyme specificity which leads to a dramatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011a565fd96c860dba45a49b79e7089c
https://doi.org/10.1007/s00401-017-1677-y
https://doi.org/10.1007/s00401-017-1677-y
Autor:
Stefan Pusch, Christian Thiede, Christel Herold-Mende, Claus Dieter Langhans, Jörg Balss, Wolfgang Buckel, Andreas von Deimling, Jürgen G. Okun, Ann Christin Beck, Alwin Krämer
Publikováno v:
Acta Neuropathologica. 124:883-891
Levels of (D)-2-hydroxyglutarate [D2HG, (R)-2-hydroxyglutarate] are increased in some metabolic diseases and in neoplasms with mutations in the isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) genes. Determination of D2HG is of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b107eb2fd80c333b2ec4c3c73a4ccb1
https://doi.org/10.1007/s00401-012-1060-y
https://doi.org/10.1007/s00401-012-1060-y
Autor:
Stefan Pusch, Aubry K. Miller, Jörg Balss, Leonille Schweizer, Ann Christin Beck, Susanne Weissert, Johanna Marie Lehmler, Andreas von Deimling
Publikováno v:
Acta Neuropathologica Communications
Background IDH mutations frequently occur in diffuse gliomas and result in a neo-enzymatic activity that results in reduction of α-ketoglutarate to D-2-hydroxyglutarate. In gliomas, the frequency of IDH1 mutations in codon 132 increases in the order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63ea4b111df78b4f8c2742d24e51c69