Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ann Chi Yan Wong"'
Autor:
Allen Frederic Ryan, Ann Chi Yan Wong
Publikováno v:
Frontiers in Aging Neuroscience, Vol 7 (2015)
The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as w
Externí odkaz:
https://doaj.org/article/961c72bc997c417d9df5e9cdece38d92
Autor:
Miguel A. Ramirez, Jeffrey N. Savas, Ann E. Hickox, Kwang Pak, John R. Yates, Allen F. Ryan, Chelsee Strojny, Ann Chi Yan Wong
Publikováno v:
The Journal of Neuroscience. 37:1320-1339
The mammalian inner ear (IE) subserves auditory and vestibular sensations via highly specialized cells and proteins. Sensory receptor hair cells (HCs) are necessary for transducing mechanical inputs and stimulating sensory neurons by using a host of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fc38c98229ffcd94fe642f8d928c5e
https://doi.org/10.1523/jneurosci.2267-16.2016
https://doi.org/10.1523/jneurosci.2267-16.2016
Autor:
Miguel A. Ramirez, Ann Chi Yan Wong, Kwang Pak, Jintao Yu, Jeffrey N. Savas, Nopporn Jongkamonwiwat, Allen F. Ryan, Seby L. Edassery, Tirzah Abbott
Publikováno v:
Cell reports
SUMMARY Exposure to excessive sound causes noise-induced hearing loss through complex mechanisms and represents a common and unmet neurological condition. We investigate how noise insults affect the cochlea with proteomics and functional assays. Quan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2286db3dd15911feb532101cc853453
https://doi.org/10.1016/j.celrep.2020.108431
https://doi.org/10.1016/j.celrep.2020.108431
Autor:
Peter W. Gunning, Gary D. Housley, Cesar P. Canales, Stephen J. Palmer, Edna C. Hardeman, Ann Chi Yan Wong
Publikováno v:
European Journal of Human Genetics. 23:774-780
Williams–Beuren Syndrome (WBS) is a rare genetic condition caused by a hemizygous deletion involving up to 28 genes within chromosome 7q11.23. Among the spectrum of physical and neurological defects in WBS, it is common to find a distinctive respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973bbafdf5a94eb9c88a93ad67825476
https://doi.org/10.1038/ejhg.2014.188
https://doi.org/10.1038/ejhg.2014.188
Publikováno v:
Hearing Research. 304:145-152
NADPH oxidases are enzymes that transport electrons across the plasma membrane and generate superoxide radical from molecular oxygen. The current study investigated the expression and distribution of NOX/DUOX members of the NADPH oxidase family (NOX1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7588a8c609a28f11a6a2449525a29e3
https://doi.org/10.1016/j.heares.2013.07.012
https://doi.org/10.1016/j.heares.2013.07.012
Publikováno v:
European Journal of Neuroscience. 37:1478-1486
The physiological significance of canonical transient receptor potential (TRPC) ion channels in sensory systems is rapidly emerging. Heterologous expression studies show that TRPC3 is a significant Ca 2+ entry pathway, with dual activation via G prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449baa8e8f8996f70af5f23884a3e52f
https://doi.org/10.1111/ejn.12158
https://doi.org/10.1111/ejn.12158
Autor:
Matthew R. Skelton, Srdjan M. Vlajkovic, Ann Chi Yan Wong, Peter R. Thorne, Sailakshmi Velamoor
Publikováno v:
Histochemistry and Cell Biology. 137:599-613
Physiological processes in the cochlea associated with sound transduction and maintenance of the unique electrochemical environment are metabolically demanding. Creatine maintains ATP homeostasis by providing high-energy phosphates for ATP regenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503d663036d7e1ca4b51db663bb07275
https://doi.org/10.1007/s00418-012-0922-7
https://doi.org/10.1007/s00418-012-0922-7
Post exposure administration of A1 adenosine receptor agonists attenuates noise-induced hearing loss
Autor:
Ann Chi Yan Wong, Cindy X. Guo, Rita Gupta, Gary D. Housley, Srdjan M. Vlajkovic, Peter R. Thorne
Publikováno v:
Hearing Research. 260:81-88
Adenosine is a constitutive cell metabolite with a putative role in protection and regeneration in many tissues. This study was undertaken to determine if adenosine signalling pathways are involved in protection against noise injury. A1 adenosine rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48f0a2c86fa6010d52c5da7319c6f93
https://doi.org/10.1016/j.heares.2009.12.004
https://doi.org/10.1016/j.heares.2009.12.004
Autor:
Kristina E. Froud, Jennie M. E. Cederholm, Allen F. Ryan, Gary D. Housley, Ann Chi Yan Wong, Matthias Klugmann, Jean-Pierre Julien, Shaun L. Sandow
Publikováno v:
Nature communications, vol 6, iss 1
Nature Communications
Nature Communications
The dynamic adjustment of hearing sensitivity and frequency selectivity is mediated by the medial olivocochlear efferent reflex, which suppresses the gain of the ‘cochlear amplifier' in each ear. Such efferent feedback is important for promoting di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1200dbb07b40e986c3549c77105e1832
https://escholarship.org/uc/item/46s8t2p6
https://escholarship.org/uc/item/46s8t2p6
Autor:
Jeremy L. Pinyon, Edward N. Crawford, Ann Chi Yan Wong, Gary D. Housley, Isabella T. Tompson, Sherif F. Tadros, Kristina E. Froud, Renée Morris, Myungseo Ko, Matthias Klugmann
Publikováno v:
Science Translational Medicine. 6
The cochlear implant is the most successful bionic prosthesis and has transformed the lives of people with profound hearing loss. However, the performance of the "bionic ear" is still largely constrained by the neural interface itself. Current spread
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2517183a8d1ead8d54e847f669f35ef3
https://doi.org/10.1126/scitranslmed.3008177
https://doi.org/10.1126/scitranslmed.3008177