Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ann C. Petersen"'
Publikováno v:
Organic Letters. 21:9001-9004
DNA-encoded libraries (DELs) have generated recent interest due to their ability to provide new small molecule ligands for pharmaceutically important proteins. The chemical diversity of DELs determines their ability to provide potent, novel, and drug
Autor:
Bernd Kuhn, Franziska Weibel, Rodolfo Gasser, Marco Prunotto, Solange Moll, Martine Stihle, R. Daniel Bonfil, Bernard Gsell, Christian Faul, Remo Hochstrasser, Sabine Uhles, Guy Georges, Ann C. Petersen, Javier Varona Santos, Ricardo Hermosilla, Alexander L. Satz, Hans Richter, Rafael Fridman, Marc Bedoucha, Markus G. Rudolph, Bernd Buettelmann, Anja Harmeier, Martin Ritter, Melanie N. Hug, Alessia Fornoni, Judith Molina-David, Jin Ju Kim, Sylwia Huber, Buelent Kocer, Dominique Burger
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, Vol. 14, No 1 (2019) pp. 37-49
ACS Chemical Biology, Vol. 14, No 1 (2019) pp. 37-49
The importance of Discoidin Domain Receptor 1 (DDR1) in renal fibrosis has been shown via gene knockout and use of antisense oligonucleotides; however, these techniques act via a reduction of DDR1 protein, while we prove the therapeutic potential of
Publikováno v:
ACS Combinatorial Science. 19:234-238
To optimize future DNA-encoded library design, we have attempted to quantify the library size at which the signal becomes undetectable. To accomplish this we (i) have calculated that percent yields of individual library members following a screen ran
Autor:
Daisy Carvajal, Ann C. Petersen, Cheryl Janson, Wei He, Javier de Vicente, Hong Qian, Christine Lukacs, Lin Yi, Kuo-Sen Huang, Johannes C. Hermann, Yong Zhuang, David Robert Bolin, Pamela Berry, Lena Liang, Parcharee Tivitmahaisoon
Publikováno v:
ACS Medicinal Chemistry Letters. 6:1019-1024
Tankyrase activity has been linked to the regulation of intracellular axin levels, which have been shown to be crucial for the Wnt pathway. Deregulated Wnt signaling is important for the genesis of many diseases including cancer. We describe herein t
Autor:
Shirley Li, Kelly M. George, Shelley K. Gleason, Charles Wartchow, Binh Thanh Vu, Hong Qian, Ann C. Petersen, Qing-Fen Gan, Lin Gao, Gabriel Stephen Deems, Linghao Niu, Nanda Beatini, Johannes C. Hermann, Arjun Narayanan, John Menke, Nathan Robert Scott, Nancy-Ellen Haynes, Yingsi Chen
Publikováno v:
ACS Medicinal Chemistry Letters. 4:197-200
Organic impurities in compound libraries are known to often cause false-positive signals in screening campaigns for new leads, but organic impurities do not fully account for all false-positive results. We discovered inorganic impurities in our scree
Autor:
Ann C. Petersen, Andreas Jekle, David Mark Rotstein, André deRosier, Remy Lemoine, Changhua Ji, Gabrielle Heilek, Lina Setti, Pamela Berry
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4753-4756
The introduction of N-substituted pyrazoles in a new series of CCR5 antagonists was shown to substantially increase antiviral activity.
Autor:
David Mark Rotstein, André deRosier, Jutta Wanner, Gabrielle Heilek, Andreas Jekle, Changhua Ji, Lijing Chen, Remy Lemoine, Ann C. Petersen, Lina Setti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1830-1833
The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the conformationally restricted 4-aminopiperidine ring found in several series of CCR5 antagonists.
Autor:
Goli Naderi-Oboodi, Quentin Strebel, Ann C. Petersen, Lucja Orzechowski, Jianping Cai, Agnieszka Kowalczyk, Yi Chen, Alexander L. Satz, Felix Gruber, Robert Alan Goodnow
Publikováno v:
Bioconjugate chemistry. 26(8)
Complex mixtures of DNA encoded small molecules may be readily interrogated via high-throughput sequencing. These DNA encoded libraries (DELs) are commonly used to discover molecules that interact with pharmaceutically relevant proteins. The chemical
Autor:
David Mark Rotstein, André deRosier, Gabrielle Heilek, Lina Setti, Remy Lemoine, Changhua Ji, Jutta Wanner, Ann C. Petersen, Thomas Baldinger, Andreas Jekle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1674-1676
The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the 3-amino-8-azabicyclo[3.2.1]octane found in the CCR5 antagonist maraviroc.
Autor:
Yi Chen, Ann C. Petersen, Robert Alan Goodnow, Goli Naderi-Oboodi, Alexander L. Satz, Agnieszka Kowalczyk, Felix Gruber, Lucja Orzechowski, Jianping Cai, Quentin Strebel
Publikováno v:
Bioconjugate Chemistry. 27:2580-2580