Výsledky vyhledávání - "Ann C. Mladek"

Akademický článek

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Despite major drug discovery efforts, the therapeutic options for glioblastoma (GBM) remain inadequate. Here they analyze patient-derived xenograft model of GBM to quantitatively map distribution and cellular response to the EGFR inhibitor erlotinib,

Externí odkaz: https://doaj.org/article/17219987055045cbbd74e20d4356a523

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Akademický článek

PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity

Autor: Shiv K. Gupta, Emily J. Smith, Ann C. Mladek, Shulan Tian, Paul A. Decker, Sani H. Kizilbash, Gaspar J. Kitange, Jann N. Sarkaria

Publikováno v: Frontiers in Oncology, Vol 8 (2019)

Prognosis of patients with glioblastoma (GBM) remains dismal despite maximal surgical resection followed by aggressive chemo-radiation therapy. Almost every GBM, regardless of genotype, relapses as aggressive recurrent disease. Sensitization of GBM c

Externí odkaz: https://doaj.org/article/aadda5d7499241cebbf1b673ba724aab

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Akademický článek

Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

Autor: Gaspar J. Kitange, Ann C. Mladek, Mark A. Schroeder, Jenny C. Pokorny, Brett L. Carlson, Yuji Zhang, Asha A. Nair, Jeong-Heon Lee, Huihuang Yan, Paul A. Decker, Zhiguo Zhang, Jann N. Sarkaria

Publikováno v: Cell Reports, Vol 14, Iss 11, Pp 2587-2598 (2016)

Here we provide evidence that RBBP4 modulates temozolomide (TMZ) sensitivity through coordinate regulation of two key DNA repair genes critical for recovery from TMZ-induced DNA damage: methylguanine-DNA-methyltransferase (MGMT) and RAD51. Disruption

Externí odkaz: https://doaj.org/article/8e14b685c3304c7fa147e80847088793

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Akademický článek

Disruption of Parallel and Converging Signaling Pathways Contributes to the Synergistic Antitumor Effects of Simultaneous mTOR and EGFR Inhibition in GBM Cells

Autor: Ravi D. Rao, Ann C. Mladek, Jeffrey D. Lamont, Jennie M. Goble, Charles Erlichman, C. David James, Jann N. Sarkaria

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 10, Pp 921-929 (2005)

Elevated epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) signaling are known to contribute to the malignant properties of glioblastoma multiforme (GBM), which include uncontrolled cell proliferation and evasion of apo

Externí odkaz: https://doaj.org/article/1115f966e5754d1c80e56b364df5c242

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WSD-0922, a novel brain-penetrant inhibitor of EGFR, promotes survival in glioblastoma mouse models

Publikováno v: Neuro-Oncology Advances.

Background Although the epidermal growth factor receptor (EGFR) is a frequent oncogenic driver in glioblastoma (GBM), efforts to therapeutically target this protein have been largely unsuccessful. The present pre-clinical study evaluated the novel EG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2ce3a1d223fff1c6b6c405e08aedd04
https://doi.org/10.1093/noajnl/vdad066

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Supplementary Figure S5 from Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth

Autor: Jann N. Sakaria, Richard T. Wheelhouse, Alonzo H. Ross, Jarkko Rautio, Mikko Gynther, Roger M. Phillips, Ann C. Mladek, Yulian P. Ramirez

Supplementary Figure S5. DNA damage signaling activated by low concentrations of DP68. U251 and T98G cells were exposed to DP68 for 24 hrs and whole cell and nuclear extracts were processed for Western blotting. Representative blots from three indepe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0434cb986f1d6fcbe341f24a6769684
https://doi.org/10.1158/1535-7163.22502478.v1

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