Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ann C. McKeon"'
Autor:
Katherine D. Holland, Ann C. McKeon, Douglas F. Covey, James A. Ferrendelli, Daniel J. Canney
Publikováno v:
Epilepsia. 33:981-986
Anticonvulsant properties of compounds that enhance GABA-mediated inhibition through modulatory sites on the GABAA receptor [phenobarbital (PB), clonazepam (CZP), alpha-ethyl-alpha-methyl-gamma-thiobutyrolactone (alpha-EMTBL)] were compared with anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ad1d66f8684d2375d72590ceaf8ecb
https://doi.org/10.1111/j.1528-1157.1992.tb01747.x
https://doi.org/10.1111/j.1528-1157.1992.tb01747.x
Autor:
Katherine D. Holland, Kun Xu, Kong Woo Yoon, Steven M. Rothman, Douglas F. Covey, Ann C. McKeon, Daniel J. Canney, James A. Ferrendelli, Hwang Fun Lu
Publikováno v:
Bioorganicmedicinal chemistry. 6(1)
Dihydro-2(3H)-furanones (gamma-butyrolactones) and dihydro-2(3H)-thiophenones (gamma-thiobutyrolactones) containing fluoroalkyl groups at positions C-3, C-4, and C-5 of the heterocyclic rings were prepared. The anticonvulsant/convulsant activities of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef0e326bde76d7b5b9f36ace9acd109
https://pubmed.ncbi.nlm.nih.gov/9502104
https://pubmed.ncbi.nlm.nih.gov/9502104
Autor:
Kun Xu, Katherine D. Holland, Eileen M. Peterson, Douglas F. Covey, Ann C. McKeon, James A. Ferrendelli, Steven M. Rothman
Publikováno v:
Journal of medicinal chemistry. 37(2)
To further study the putative gamma-butyrolactone site of the GABAA/chloride channel complex, constrained derivatives of convulsant and anticonvulsant alpha,alpha-disubstituted gamma-butyrolactones (alpha-spirocyclopropyl- and alpha-spirocyclopentyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047e64b3d3c2f478b08d5792a78c0ce3
https://pubmed.ncbi.nlm.nih.gov/8295215
https://pubmed.ncbi.nlm.nih.gov/8295215
Publikováno v:
Experimental Neurology. 82:663-674
Alkyl-substituted and unsubstituted derivatives of gamma-butyrolactone (GBL), gamma-hydroxybutyrate (GHB), and succinimide were tested for their effects on the evoked potential (EP) and spontaneous activity of hippocampal slices incubated in vitro. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c693014992fb38e8750ce40dc6d0a3d
https://doi.org/10.1016/0014-4886(83)90088-2
https://doi.org/10.1016/0014-4886(83)90088-2
Publikováno v:
Annals of Neurology. 22:615-621
The ability of discrete brainstem injections of gamma-vinyl-gamma-aminobutyric acid (GVG), an irreversible inhibitor of gamma-aminobutyric acid transaminase, to prevent pentylenetetrazol (PTZ) seizures and maximal electroshock seizures (MES) was stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1300172a43db25a9537058f9ea19e03e
https://doi.org/10.1002/ana.410220510
https://doi.org/10.1002/ana.410220510
Publikováno v:
Epilepsia. 30:617-622
Summary: Anticonvulsant properties of α-ethyl-α-methyl–γ-thiobutyrolactone (α-EMTBL) were compared with those of the antiepileptic drugs ethosuximide (ESM) and valproate (VPA) by testing their ability to block seizures in mice caused by maximal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bad6cf7c3584426f073ec1514b6a4a
https://doi.org/10.1111/j.1528-1157.1989.tb05482.x
https://doi.org/10.1111/j.1528-1157.1989.tb05482.x
Publikováno v:
Chemischer Informationsdienst. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99383f3743e49de56f806126c795d7ee
https://doi.org/10.1002/chin.198310211
https://doi.org/10.1002/chin.198310211
Publikováno v:
Science (New York, N.Y.). 217(4564)
Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07427a03be8d1755d4267ff17cb576d
https://pubmed.ncbi.nlm.nih.gov/6810462
https://pubmed.ncbi.nlm.nih.gov/6810462