Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Ann C Williams"'
Autor:
Sandra Montes-Olivas, Danny Legge, Abbie Lund, Alexander G Fletcher, Ann C Williams, Lucia Marucci, Martin Homer
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 8, p e1011386 (2023)
Organoids offer a powerful model to study cellular self-organisation, the growth of specific tissue morphologies in-vitro, and to assess potential medical therapies. However, the intrinsic mechanisms of these systems are not entirely understood yet,
Externí odkaz:
https://doaj.org/article/bc64428b884d4479a8b56223f15161f1
Autor:
Alexander Greenhough, Clare Bagley, Kate J Heesom, David B Gurevich, David Gay, Mark Bond, Tracey J Collard, Chris Paraskeva, Paul Martin, Owen J Sansom, Karim Malik, Ann C Williams
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 11, Pp 1-13 (2018)
Abstract Hypoxia is a hallmark of solid tumours and a key physiological feature distinguishing cancer from normal tissue. However, a major challenge remains in identifying tractable molecular targets that hypoxic cancer cells depend on for survival.
Externí odkaz:
https://doaj.org/article/46c54f6455b9460fbdfd09461e4f6747
Autor:
Danny N. Legge, Alex P. Shephard, Tracey J. Collard, Alexander Greenhough, Adam C. Chambers, Richard W. Clarkson, Christos Paraskeva, Ann C. Williams
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 3 (2019)
To decrease bowel cancer incidence and improve survival, we need to understand the mechanisms that drive tumorigenesis. Recently, B-cell lymphoma 3 (BCL-3; a key regulator of NF-κB signalling) has been recognised as an important oncogenic player in
Externí odkaz:
https://doaj.org/article/cd9fde3343ff408689e9cb006bd97664
Autor:
Philip C. Haycock, Maria Carolina Borges, Kimberley Burrows, Rozenn N. Lemaitre, Stephen Burgess, Nikhil K. Khankari, Konstantinos K. Tsilidis, Tom R. Gaunt, Gibran Hemani, Jie Zheng, Therese Truong, Brenda M. Birmann, Tracy OMara, Amanda B. Spurdle, Mark M. Iles, Matthew H. Law, Susan L. Slager, Fatemeh Saberi Hosnijeh, Daniela Mariosa, Michelle Cotterchio, James R. Cerhan, Ulrike Peters, Stefan Enroth, Puya Gharahkhani, Loic Le Marchand, Ann C. Williams, Robert C. Block, Christopher I. Amos, Rayjean J. Hung, Wei Zheng, Marc J. Gunter, George Davey Smith, Caroline Relton, Richard M. Martin, Nathan Tintle, Terri Rice, Iona Cheng, Mark Jenkins, Steve Gallinger, Alex J. Cornish, Amit Sud, Jayaram Vijayakrishnan, Margaret Wrensch, Mattias Johansson, Aaron D. Norman, Alison Klein, Alyssa Clay-Gilmour, Andre Franke, Andres V. Ardisson Korat, Bill Wheeler, Björn Nilsson, Caren Smith, Chew-Kiat Heng, Ci Song, David Riadi, Elizabeth B. Claus, Eva Ellinghaus, Evgenia Ostroumova, null Hosnijeh, Florent de Vathaire, Giovanni Cugliari, Giuseppe Matullo, Irene Oi-Lin Ng, Jeanette E. Passow, Jia Nee Foo, Jiali Han, Jianjun Liu, Jill Barnholtz-Sloan, Joellen M. Schildkraut, John Maris, Joseph L. Wiemels, Kari Hemminki, Keming Yang, Lambertus A. Kiemeney, Lang Wu, Laufey Amundadottir, Marc-Henri Stern, Marie-Christine Boutron, Mark Martin Iles, Mark P. Purdue, Martin Stanulla, Melissa Bondy, Mia Gaudet, Lenha Mobuchon, Nicola J. Camp, Pak Chung Sham, Pascal Guénel, Paul Brennan, Philip R. Taylor, Quinn Ostrom, Rachael Stolzenberg-Solomon, Rajkumar Dorajoo, Richard Houlston, Robert B. Jenkins, Sharon Diskin, Sonja I. Berndt, Spiridon Tsavachidis, Stephen J. Channock, Tabitha Harrison, Tessel Galesloot, Ulf Gyllensten, Vijai Joseph, Y. Shi, Wenjian Yang, Yi Lin, Stephen K. Van Den Eeden
Publikováno v:
Haycock, P C, Borges, M C, Burrows, K, Gaunt, T R, Hemani, G, Williams, A C, Davey Smith, G, Relton, C L & Martin, R M 2023, ' The association between genetically elevated polyunsaturated fatty acids and risk of cancer ', EBioMedicine, vol. 91, 104510 . https://doi.org/10.1016/j.ebiom.2023.104510
BackgroundThe causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain.MethodsUsing a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in European
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e902eeee7d75ecf1a6cf94541789012e
https://research-information.bris.ac.uk/en/publications/7cd08dd1-622d-4072-b9f5-dc6bdf4f3c0f
https://research-information.bris.ac.uk/en/publications/7cd08dd1-622d-4072-b9f5-dc6bdf4f3c0f
Autor:
Sandra Montes-Olivas, Danny Legge, Abbie Lund, Alexander G. Fletcher, Ann C. Williams, Lucia Marucci, Martin Homer
Organoids offer a powerful model to study cellular self-organisation, the growth of specific tissue morphologiesin-vitro, and to assess potential medical therapies. However, the intrinsic mechanisms of these systems are not entirely understood yet, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79c2465167792f8490c255d96ffdd069
https://doi.org/10.1101/2022.12.08.519603
https://doi.org/10.1101/2022.12.08.519603
Autor:
Danny Legge, Amy K Holt, Caroline J Bull, Tracey Collard, Madhu Kollareddy, Jake Bellamy, Sarah Groves, Eric H Ma, Emma Hazelwood, David Qualtrough, Borko Amulic, Karim Malik, Ann C Williams, Nicholas Jones, Emma E Vincent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7d5e5c0b2d28216b4d280f61f900cc7
https://doi.org/10.15252/rc.2022178417
https://doi.org/10.15252/rc.2022178417
Autor:
Christopher Parker, Adam C. Chambers, Dustin J. Flanagan, Jasmine Wing Yu Ho, Tracey J. Collard, Greg Ngo, Duncan M. Baird, Penny Timms, Rhys G. Morgan, Owen J. Sansom, Ann C. Williams
Publikováno v:
Parker, C, Chambers, A C, Flanagan, D J, Ho, J W Y, Collard, T J, Ngo, G, Baird, D M, Timms, P, Morgan, R G, Sansom, O J & Williams, A C 2022, ' BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination ', DNA repair, vol. 115, 103331 . https://doi.org/10.1016/j.dnarep.2022.103331
The proto-oncogene BCL-3 is upregulated in a subset of colorectal cancers (CRC), where it has been shown to enhance tumour cell survival. However, although increased expression correlates with poor patient prognosis, the role of BCL-3 in determining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b79364554502afec628f6dd8f54280
Autor:
Peter A Johnson, Sara Menegatti, Adam C Chambers, Dominic Alibhai, Tracey J Collard, Ann C Williams, Hagan Bayley, Adam W Perriman
Publikováno v:
Biofabrication. 15(1)
We describe the development of a high-throughput bioprinted colorectal cancer (CRC) spheroid platform with high levels of automation, information content, and low cell number requirement. This is achieved via the formulation of a hydrogel bioink with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acac3d9e157101f46ebeb69bfc20cc80
https://pubmed.ncbi.nlm.nih.gov/36321254
https://pubmed.ncbi.nlm.nih.gov/36321254
Autor:
Danny N. Legge, Amy K. Holt, Caroline J. Bull, Tracey J. Collard, Madhu Kollareddy, Jake Bellamy, Sarah Groves, Eric H. Ma, Emma Hazelwood, David Qualtrough, Borko Amulic, Karim Malik, Ann C. Williams, Nicholas Jones, Emma E. Vincent
Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism to support the energetic and biosynthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13803235ac78dcb8545a11cdcae5c234
https://doi.org/10.1101/2022.03.23.485483
https://doi.org/10.1101/2022.03.23.485483
Autor:
M G Thomas, Paul D. White, David E. Messenger, Adam C. Chambers, Ann C. Williams, Steven William Dixon
Publikováno v:
The British Journal of Surgery
Background Evidence is emerging that the incidence of colorectal cancer is increasing in young adults, but the descriptive epidemiology required to better understand these trends is currently lacking. Methods A population‐based cohort study was car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5da0a3f792739f4971c83746930e0e
https://doi.org/10.1002/bjs.11486
https://doi.org/10.1002/bjs.11486