Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Ann Brasey"'
1
Akademický článek
Combined PD-L1 and TIM3 blockade improves expansion of fit human CD8+ antigen-specific T cells for adoptive immunotherapy
Autor: Shirin Lak, Valérie Janelle, Anissa Djedid, Gabrielle Boudreau, Ann Brasey, Véronique Lisi, Ali Smaani, Cédric Carli, Lambert Busque, Vincent-Philippe Lavallée, Jean-Sébastien Delisle
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 230-245 (2022)
Antigen-specific T cell expansion ex vivo followed by adoptive transfer enables targeting of a multitude of microbial and cancer antigens. However, clinical-scale T cell expansion from rare precursors requires repeated stimulation, which may lead to
Externí odkaz: https://doaj.org/article/69663426dd644361ad6f2f2b985cbce2
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2
Akademický článek
Two types of human TCR differentially regulate reactivity to self and non-self antigens
Autor: Assya Trofimov, Philippe Brouillard, Jean-David Larouche, Jonathan Séguin, Jean-Philippe Laverdure, Ann Brasey, Gregory Ehx, Denis-Claude Roy, Lambert Busque, Silvy Lachance, Sébastien Lemieux, Claude Perreault
Publikováno v: iScience, Vol 25, Iss 9, Pp 104968- (2022)
Summary: Based on analyses of TCR sequences from over 1,000 individuals, we report that the TCR repertoire is composed of two ontogenically and functionally distinct types of TCRs. Their production is regulated by variations in thymic output and term
Externí odkaz: https://doaj.org/article/a9f97c8afa7345dc8569a22a90492572
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5
Combined PD-L1 and TIM-3 blockade improves the expansion of fit human CD8+ antigen-specific T cells for adoptive immunotherapy
Autor: Anissa Djedid, Lambert Busque, Véronique Lisi, Jean-Sébastien Delisle, Valérie Janelle, Ann Brasey, Vincent-Philippe Lavallée, Shirin Lak, Gabrielle Boudreau, Cédric Carli
BackgroundThe stimulation and expansion of antigen-specific T cells ex vivo enables the targeting of a multitude of cancer antigens. However, clinical scale T-cell expansion from rare precursors requires repeated stimulations ex vivo leading to T-cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69f5207fdd31befbebaed580b0e1c1c7
https://doi.org/10.1101/2021.08.30.21262835
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7
UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections
Autor: Guillaume B Cardin, Jean-Sébastien Delisle, Léa Bernard, Maude Dumont-Lagacé, Claude Perreault, Cédric Carli, Denis-Claude Roy, Jean Roy, Sandra Cohen, Lambert Busque, Silvy Lachance, Ann Brasey, Imran Ahmad, Mégane Tanguay, Nadia M. Bambace, Qi Li, Guy Sauvageau, Simon F. Dufresne, Tibila Kientega, Francis Rodier, Jalila Chagraoui, Assya Trofimov, Sébastien Lemieux, Thomas Kiss
Publikováno v: Transplantation and Cellular Therapy. 27:76.e1-76.e9
Introduction Rapid T cell reconstitution following hematopoietic stem cell transplantation is essential for protection against infections and has been associated with lower incidence of chronic graft-vs-host disease (cGVHD), relapse and transplant-re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75ddaf99e084e924923a9d2d309275f
https://doi.org/10.1016/j.bbmt.2020.09.031
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8
Clinical-Scale Rapid Autologous BK Virus-Specific T Cell Line Generation From Kidney Transplant Recipients With Active Viremia for Adoptive Immunotherapy
Autor: Julie Orio, Thomas Pincez, Cédric Carli, Victoria Georges-Tobar, Caroline Lamarche, Mathieu Goupil, Ann Brasey, Lambert Busque, Jean-Sébastien Delisle, Amina Dahmani
Publikováno v: Transplantation. 101(11)
Background Polyomavirus-associated nephropathy (PVAN) after BK virus reactivation in kidney transplant recipients (KTR) can compromise graft survival. Lowering immunosuppression is the only established approach to prevent or treat PVAN but nonspecifi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f170a5acd5a5fb7dd1ab6fdd3c995ac
https://pubmed.ncbi.nlm.nih.gov/28230645
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10
General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation
Autor: Maxim A. Skabkin, Yuri V. Svitkin, Ann Brasey, Lev P. Ovchinnikov, Valentina Evdokimova, Akiko Yanagiya, Tatyana V. Pestova, Daniel Fantus, Nahum Sonenberg, William C. Merrick, Hiroaki Imataka
Publikováno v: The EMBO Journal. 28:58-68
The interaction between the poly(A)-binding protein (PABP) and eukaryotic translational initiation factor 4G (eIF4G), which brings about circularization of the mRNA, stimulates translation. General RNA-binding proteins affect translation, but their r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebef97e3e2065cbe8614b61a93da406
https://doi.org/10.1038/emboj.2008.259
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