Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ann Boija"'
Autor:
Sebastian Pomplun, Muhammad Jbara, Carly K. Schissel, Susana Wilson Hawken, Ann Boija, Charles Li, Isaac Klein, Bradley L. Pentelute
Publikováno v:
ACS Central Science, Vol 7, Iss 8, Pp 1408-1418 (2021)
Externí odkaz:
https://doaj.org/article/f510c4e0886a49d7a7adb95522e6ac22
Autor:
Kelvin Yeung, Ann Boija, Edvin Karlsson, Per-Henrik Holmqvist, Yonit Tsatskis, Ilaria Nisoli, Damian Yap, Alireza Lorzadeh, Michelle Moksa, Martin Hirst, Samuel Aparicio, Manolis Fanto, Per Stenberg, Mattias Mannervik, Helen McNeill
Publikováno v:
eLife, Vol 6 (2017)
Mutations in human Atrophin1, a transcriptional corepressor, cause dentatorubral-pallidoluysian atrophy, a neurodegenerative disease. Drosophila Atrophin (Atro) mutants display many phenotypes, including neurodegeneration, segmentation, patterning an
Externí odkaz:
https://doaj.org/article/0bd2f64c752349fd9c79d349b5cff0b5
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002769 (2012)
CBP and the related p300 protein are widely used transcriptional co-activators in metazoans that interact with multiple transcription factors. Whether CBP/p300 occupies the genome equally with all factors or preferentially binds together with some fa
Externí odkaz:
https://doaj.org/article/c190130f8aab47d2962b77f6100c5588
Autor:
Ann Boija, Carly K. Schissel, Isaac A. Klein, Susana Wilson Hawken, Bradley L. Pentelute, Muhammad Jbara, Sebastian Pomplun, Charles H. Li
Publikováno v:
ACS Central Science
ACS Central Science, Vol 7, Iss 8, Pp 1408-1418 (2021)
ACS Central Science, Vol 7, Iss 8, Pp 1408-1418 (2021)
Dysregulation of the transcription factor MYC is involved in many human cancers. The dimeric transcription factor complexes of MYC/MAX and MAX/MAX activate or inhibit, respectively, gene transcription upon binding to the same enhancer box DNA. Target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a061c93d968e2740e4fe092e0edcc085
https://doi.org/10.1021/acscentsci.1c00663
https://doi.org/10.1021/acscentsci.1c00663
Autor:
Arup K. Chakraborty, John Mantiega, Anthony A. Hyman, Ann Boija, Mrityunjoy Kar, Patrick M. McCall, Jesse M. Platt, Charles H. Li, Mengyang Fan, Victoria E. Clark, Tong Lee, Alessandra Dall’Agnese, Jonathan E. Henninger, Krishna Shrinivas, Ido Sagi, Phillip A. Sharp, Dylan J. Taatjes, Tim-Michael Decker, Tinghu Zhang, Jing-Ke Weng, Eliot L. Coffey, Lena K. Afeyan, Alicia V. Zamudio, Nathanael S. Gray, Benjamin R. Sabari, Isaac A. Klein, Richard A. Young, Nancy M. Hannett, Young-Tae Chang, Ozgur Oksuz, Yang Guo, Susana Wilson Hawken
Publikováno v:
Cancer Research. 81:GS3-10
The molecules of the cell are compartmentalized into membrane- and non-membrane-bound organelles. Many non-membrane-bound organelles are phase-separated biomolecular condensates with distinct physicochemical properties that can absorb and concentrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::813421c57b00b902403b00605df75237
https://doi.org/10.1158/1538-7445.sabcs20-gs3-10
https://doi.org/10.1158/1538-7445.sabcs20-gs3-10
Publikováno v:
Molecular Cell. 82:3580-3597.e9
Maintenance of appropriate cell states involves epigenetic mechanisms, including Polycomb-group (PcG)-mediated transcriptional repression. While PcG proteins are known to induce chromatin compaction, how PcG proteins gain access to DNA in compact chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fde6931cd56bb8f182ae786a34dff7b
https://doi.org/10.1016/j.molcel.2022.09.005
https://doi.org/10.1016/j.molcel.2022.09.005
Autor:
Susana Wilson Hawken, Stephen L. Buchwald, Sebastian Pomplun, Ann Boija, Bradley L. Pentelute, Carly K. Schissel, Isaac A. Klein, Muhammad Jbara, Jacob Rodriguez
Publikováno v:
Journal of the American Chemical Society. 143(30)
Transcription factors (TF), such as Myc, are proteins implicated in disease pathogenesis, with dysregulation of Myc expression in 50% of all human cancers. Still, targeting Myc remains a challenge due to the lack of small molecule binding pockets in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f094a401bec8cff03c4d0b1c35f053ab
https://pubmed.ncbi.nlm.nih.gov/34289685
https://pubmed.ncbi.nlm.nih.gov/34289685
Autor:
Yang Eric Guo, Brian J. Abraham, Tim-Michael Decker, Dylan J. Taatjes, Jenna K. Rimel, Phillip A. Sharp, Tong Ihn Lee, Charli B. Fant, John C. Manteiga, Krishna Shrinivas, Lena K. Afeyan, Benjamin R. Sabari, Richard A. Young, Jan-Hendrik Spille, Jonathan E. Henninger, Alessandra Dall’Agnese, Alicia V. Zamudio, Nancy M. Hannett, Ann Boija, Ibrahim I Cisse
Publikováno v:
Nature
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex1–4. The large subunit of Pol II contains an intrinsically disordered C-terminal domain t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd05b7c69848ab64e299895bb7068c6d
https://doi.org/10.1038/s41586-019-1464-0
https://doi.org/10.1038/s41586-019-1464-0
Publikováno v:
Cancer Cell
Prof. Richard Young
Prof. Richard Young
Malignant transformation is characterized by dysregulation of diverse cellular processes that have been the subject of detailed genetic, biochemical, and structural studies, but only recently has evidence emerged that many of these processes occur in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18168ae6dfb52334329528c33398eed1
https://pubmed.ncbi.nlm.nih.gov/33417833
https://pubmed.ncbi.nlm.nih.gov/33417833
Autor:
Christoph Neumayr, Vanja Haberle, Leonid Serebreni, Katharina Karner, Oliver Hendy, Ann Boija, Jonathan E. Henninger, Charles H. Li, Karel Stejskal, Gen Lin, Katharina Bergauer, Michaela Pagani, Martina Rath, Karl Mechtler, Cosmas D. Arnold, Alexander Stark
Publikováno v:
Nature. 606(7913)
All multicellular organisms rely on differential gene transcription regulated by genomic enhancers, which function through cofactors that are recruited by transcription factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f37657af839c589a451c9b07d1a9a7
https://pubmed.ncbi.nlm.nih.gov/35985301
https://pubmed.ncbi.nlm.nih.gov/35985301