Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Ann Becker"'
Autor:
Katarzyna Marta Zoltowska, Utpal Das, Sam Lismont, Thomas Enzlein, Masato Maesako, Mei CQ Houser, Maria Luisa Franco, Burcu Özcan, Diana Gomes Moreira, Dmitry Karachentsev, Ann Becker, Carsten Hopf, Marçal Vilar, Oksana Berezovska, William Mobley, Lucía Chávez-Gutiérrez
Publikováno v:
eLife, Vol 12 (2024)
Amyloid β (Aβ) peptides accumulating in the brain are proposed to trigger Alzheimer’s disease (AD). However, molecular cascades underlying their toxicity are poorly defined. Here, we explored a novel hypothesis for Aβ42 toxicity that arises from
Externí odkaz:
https://doaj.org/article/2631ca395939430b962c9f2eb0249faf
Autor:
Cassia Overk, Emma Fiorini, Chiara Babolin, Marija Vukicevic, Catherine Morici, Rime Madani, Valerie Eligert, Marie Kosco-Vilbois, Amanda Roberts, Ann Becker, Andrea Pfeifer, William C. Mobley
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionPeople with DS are highly predisposed to Alzheimer’s disease (AD) and demonstrate very similar clinical and pathological features. Ts65Dn mice are widely used and serve as the best-characterized animal model of DS.MethodsWe undertook st
Externí odkaz:
https://doaj.org/article/7e7e2a8942f745cbb81e9ba1997aa1c8
Autor:
Heshan Peiris, Michael D Duffield, Joao Fadista, Claire F Jessup, Vinder Kashmir, Amanda J Genders, Sean L McGee, Alyce M Martin, Madiha Saiedi, Nicholas Morton, Roderick Carter, Michael A Cousin, Alexandros C Kokotos, Nikolay Oskolkov, Petr Volkov, Tertius A Hough, Elizabeth M C Fisher, Victor L J Tybulewicz, Jorge Busciglio, Pinar E Coskun, Ann Becker, Pavel V Belichenko, William C Mobley, Michael T Ryan, Jeng Yie Chan, D Ross Laybutt, P Toby Coates, Sijun Yang, Charlotte Ling, Leif Groop, Melanie A Pritchard, Damien J Keating
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006033 (2016)
Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to β-cell dysfunction. Mitochondrial
Externí odkaz:
https://doaj.org/article/55d1108814ad40e3b162e4623311cfe8
Autor:
Pavel V Belichenko, Rime Madani, Lorianne Rey-Bellet, Maria Pihlgren, Ann Becker, Adeline Plassard, Stephanie Vuillermot, Valérie Giriens, Rachel L Nosheny, Alexander M Kleschevnikov, Janice S Valletta, Sara K S Bengtsson, Gordon R Linke, Michael T Maloney, David T Hickman, Pedro Reis, Anne Granet, Dorin Mlaki, Maria Pilar Lopez-Deber, Long Do, Nishant Singhal, Eliezer Masliah, Matthew L Pearn, Andrea Pfeifer, Andreas Muhs, William C Mobley
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152471 (2016)
In Down syndrome (DS) or trisomy of chromosome 21, the β-amyloid (Aβ) peptide product of the amyloid precursor protein (APP) is present in excess. Evidence points to increased APP gene dose and Aβ as playing a critical role in cognitive difficulti
Externí odkaz:
https://doaj.org/article/e6e5615e619c41a0ad64eafb049c71c7
Autor:
Pavel V Belichenko, Alexander M Kleschevnikov, Ann Becker, Grant E Wagner, Larisa V Lysenko, Y Eugene Yu, William C Mobley
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134861 (2015)
Down syndrome (DS), trisomy for chromosome 21, is the most common genetic cause of intellectual disability. The genomic regions on human chromosome 21 (HSA21) are syntenically conserved with regions on mouse chromosomes 10, 16, and 17 (Mmu10, Mmu16,
Externí odkaz:
https://doaj.org/article/d51c038fdc8148899fbd97c4cd544d85
Publikováno v:
Alzheimer's & Dementia. 19:2095-2116
Synaptic failure, a hallmark of Alzheimer's disease (AD), is correlated with reduced levels of synaptic proteins. Though people with Down syndrome (DS) are at markedly increased risk for AD (AD-DS), few studies have addressed synapse dysfunction.Syna
Autor:
Xu‐Qiao Chen, Mariko Sawa, Ann Becker, Dmitry Karachentsev, Xinxin Zuo, Kevin D. Rynearson, Rudolph E. Tanzi, William C. Mobley
Publikováno v:
Annals of Neurology.
Autor:
Amelia Ann Becker
Publikováno v:
Proceedings of the Annual Meetings on Phonology. 9
The research community generally accepts that signed and spoken languages contain both iconicity and arbitrariness. Iconicity's impact on statistical distributions of motivated forms throughout signed language lexicons is clear (e.g. Occhino, 2016).
Autor:
William C. Mobley, Ahmad Salehi, Cassia R. Overk, Y. Eugene Yu, Kim Weldy, Eric Doran, Ann Becker, Ricardo Albay, Mariko Sawa, Thomas G. Beach, Dominique Derse, Elizabeth Head
Publikováno v:
Alzheimers Dement
Introduction People with Down syndrome (DS) are predisposed to Alzheimer's disease (AD). The amyloid hypothesis informs studies of AD. In AD-DS, but not sporadic AD, increased APP copy number is necessary, defining the APP gene dose hypothesis. Which
Autor:
William C. Mobley, Robert A. Rissman, Gopal Thinakaran, Brian P. Head, Rudolph E. Tanzi, Steven K. Duddy, Yuhuan Xie, Moorthi Ponnusamy, Michael Mante, Jiunn H. Lin, Olga Prikhodko, Ann Becker, Brian Spencer, Kevin D. Rynearson, Steven L. Wagner, Brenda Hug, Douglas Galasko, Graham Johnson, Bahar Salehi, Jazmin Florio, Can Zhang, Mariko Sawa, Carlos Arias, Phuong Nguyen
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, vol 218, iss 4
Journal of Experimental Medicine, vol 218, iss 4
GSMs preferentially attenuate levels of the aggregation-prone Aβ42 peptide by binding to the γ-secretase enzyme and altering exopeptidase-like processing. Rynearson et al. demonstrate the ability of an advanced-stage GSM to robustly attenuate Aβ42