Detection of VEGF-A(xxx)b isoforms in human tissues.

Autor: David O Bates, Athina Mavrou, Yan Qiu, James G Carter, Maryam Hamdollah-Zadeh, Shaney Barratt, Melissa V Gammons, Ann B Millar, Andrew H J Salmon, Sebastian Oltean, Steven J Harper

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e68399 (2013)

Vascular Endothelial Growth Factor-A (VEGF-A) can be generated as multiple isoforms by alternative splicing. Two families of isoforms have been described in humans, pro-angiogenic isoforms typified by VEGF-A165a, and anti-angiogenic isoforms typified

Externí odkaz: https://doaj.org/article/c5e11b23554f49f3992873cd602d0d0f

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)

Autor: Shaney L. Barratt, Thomas Blythe, Khadija Ourradi, Caroline Jarrett, Gavin I. Welsh, David O. Bates, Ann B. Millar

Publikováno v: Respiratory Research, Vol 19, Iss 1, Pp 1-5 (2018)

Abstract Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its translational regulation by HIF-1�

Externí odkaz: https://doaj.org/article/120bb84e425d477797fb1bb9fb2175c7

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

Autor: Simon P. Hart, Vilmundur Gudnason, Yingze Zhang, Hiroto Hatabu, Rebecca Braybrooke, R. Gisli Jenkins, Shwu-Fan Ma, Michael Ng, Carlos Flores, George T. O'Connor, Ma'en Obeidat, Nik Hirani, Brian D. Hobbs, Megan L. Paynton, Amy Dressen, Ayodeji Adegunsoye, Helen Booth, Dominic Furniss, Philippe Joubert, Eunice Oballa, Ian Sayers, Martin D. Tobin, Krina T. Zondervan, Richard Hubbard, Xuan Li, Yohan Bossé, John D. Newell, Beatriz Guillen-Guio, Ann B. Millar, Wim Timens, Mary E. Strek, Gunnar Gudmundsson, Philip L. Molyneaux, Gary M. Hunninghake, Ani Manichaikul, Tasha E. Fingerlin, Rachel K. Putman, Richard J. Allen, Vidyia Navaratnam, Maria Molina-Molina, Don D. Sin, Helen Parfrey, Luke M. Kraven, Moira K. B. Whyte, Xuting R. Sheng, Phuwanat Sakornsakolpat, David J. Lederer, David C. Nickle, Ian P. Hall, Brian L. Yaspan, Louise V. Wain, Toby M. Maher, Gauri Saini, Ke Hao, Michael Hill, Naftali Kaminski, Andrew P. Morris, Hanfei Xu, Justin M. Oldham, David A. Schwartz, Robin J. McAnulty, Michael H. Cho, Victor E. Ortega, Margaret Neighbors, Imre Noth, William A. Fahy

Publikováno v: Allen, R J, Guillen-guio, B, Oldham, J M, Ma, S, Dressen, A, Paynton, M L, Kraven, L M, Obeidat, M, Li, X, Ng, M, Braybrooke, R, Molina-molina, M, Hobbs, B D, Putman, R K, Sakornsakolpat, P, Booth, H L, Fahy, W A, Hart, S P, Hill, M R, Hirani, N, Hubbard, R B, Mcanulty, R J, Millar, A B, Navaratnam, V, Oballa, E, Parfrey, H, Saini, G, Whyte, M K B, Zhang, Y, Kaminski, N, Adegunsoye, A, Strek, M E, Neighbors, M, Sheng, X R, Gudmundsson, G, Gudnason, V, Hatabu, H, Lederer, D J, Manichaikul, A, Newell Jr., J D, O'connor, G T, Ortega, V E, Xu, H, Fingerlin, T E, Bossé, Y, Hao, K, Joubert, P, Nickle, D C, Sin, D D, Timens, W, Furniss, D, Morris, A P, Zondervan, K, Hall, I P, Sayers, I, Tobin, M D, Maher, T M, Cho, M H, Hunninghake, G M, Schwartz, D A, Yaspan, B L, Molyneaux, P L, Flores, C, Noth, I, Jenkins, R G & Wain, L V 2020, ' Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis ', American Journal of Respiratory and Critical Care Medicine, vol. 201, no. 5, pp. 564-574 . https://doi.org/10.1164/rccm.201905-1017OC
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
American Journal of Respiratory and Critical Care Medicine, 201(5), 564-574. AMER THORACIC SOC
Allen, R J, Guillen-Guio, B, Oldham, J M, Ma, S-F, Dressen, A, Paynton, M L, Kraven, L M, Obeidat, M, Li, X, Ng, M, Braybrooke, R, Molina-Molina, M, Hobbs, B D, Putman, R K, Sakornsakolpat, P, Booth, H L, Fahy, W A, Hart, S P, Hill, M R, Hirani, N, Hubbard, R B, McAnulty, R J, Millar, A B, Navaratnam, V, Oballa, E, Parfrey, H, Saini, G, Whyte, M K B, Zhang, Y, Kaminski, N, Adegunsoye, A, Strek, M E, Neighbors, M, Sheng, X R, Gudmundsson, G, Gudnason, V, Hatabu, H, Lederer, D J, Manichaikul, A, Newell, J D, O'Connor, G T, Ortega, V E, Xu, H, Fingerlin, T E, Bossé, Y, Hao, K, Joubert, P, Nickle, D C, Sin, D D, Timens, W, Furniss, D, Morris, A P, Zondervan, K, Hall, I P, Sayers, I, Tobin, M D, Maher, T M, Cho, M H, Hunninghake, G M, Schwartz, D A, Yaspan, B L, Molyneaux, P L, Flores, C, Noth, I, Jenkins, R G & Wain, L V 2019, ' Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.201905-1017OC
American Journal of Respiratory and Critical Care Medicine

Publisher's version (útgefin grein)
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f735d247fb5068243ea799597c642afa
https://www.research.manchester.ac.uk/portal/en/publications/genomewide-association-study-of-susceptibility-to-idiopathic-pulmonary-fibrosis(6fbf4813-b9fe-4644-bec4-7b50df3d4de2).html

Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis

Autor: George T. O'Connor, Gauri Saini, Helen Booth, Dominic Furniss, William A. Fahy, Ke Hao, Beatriz Guillen-Guio, Vilmundur Gudnason, Brian L. Yaspan, Imre Noth, Hanfei Xu, Hiroto Hatabu, Brian D. Hobbs, Ma'en Obeidat, Nik Hirani, Justin M. Oldham, Victor E. Ortega, David A. Schwartz, Simon P. Hart, Ani Manichaikul, Richard Hubbard, Xuan Li, Philippe Joubert, Michael Hill, Michael Ng, Ann B. Millar, Vidyia Navaratnam, Richard J. Allen, Rebecca Braybrooke, Ian Sayers, Ian P. Hall, Shwu-Fan Ma, Philip L. Molyneaux, Carlos Flores, Tasha E. Fingerlin, Martin D. Tobin, Gunnar Gudmundsson, Rachel K. Putman, Gary M. Hunninghake, Krina T. Zondervan, Moira K. B. Whyte, Robin J. McAnulty, Louise V. Wain, Andrew P. Morris, Michael H. Cho, David C. Nickle, Don D. Sin, Helen Parfrey, Toby M. Maher, Yohan Bossé, Maria Molina-Molina, John D. Newell, Eunice Oballa, Phuwanat Sakornsakolpat, David J. Lederer, R. Gisli Jenkins, Amy Dressen, Wim Timens, Luke M. Kraven, Megan L. Paynton

RationaleIdiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. The mechanisms by which this arises are poorly understood a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d678399307d65e16ef54c3cdc669cd0
https://doi.org/10.1101/636761

Neue Erkenntnisse zur Pathogenese des akuten Atemnotsyndroms

Autor: Ann B. Millar, Andrew R L Medford, Charles Sharp

Publikováno v: Kompass Pneumologie. 4:190-208

Das klinische Syndrom der akuten Lungenschädigung (ALI; acute lung injury) entwickelt sich basierend auf einer vorausgehenden akuten systemischen Entzündungsreaktion. Diese kann auf direktem oder indirektem Wege vielfältige Schäden an der Lunge h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c9a499af00e6849d8ffa5d98db8a296
https://doi.org/10.1159/000448770