Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Ann‐Marie Baker"'
Autor:
Silvana Debernardi, Lukasz Liszka, Chara Ntala, Katja Steiger, Irene Esposito, Emanuela Carlotti, Ann‐Marie Baker, Stuart McDonald, Trevor Graham, Branko Dmitrovic, Roger M. Feakins, Tatjana Crnogorac‐Jurcevic
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 677-690 (2024)
The median age of patients with pancreatic ductal adenocarcinoma (PDAC) at diagnosis is 71 years; however, around 10% present with early‐onset pancreatic cancer (EOPC), i.e., before age 50. The molecular mechanisms underlying such an early onset ar
Externí odkaz:
https://doaj.org/article/28e44b0fd78246999dcb6ae2e2fb819c
Autor:
Chandler D. Gatenbee, Ann-Marie Baker, Sandhya Prabhakaran, Ottilie Swinyard, Robbert J. C. Slebos, Gunjan Mandal, Eoghan Mulholland, Noemi Andor, Andriy Marusyk, Simon Leedham, Jose R. Conejo-Garcia, Christine H. Chung, Mark Robertson-Tessi, Trevor A. Graham, Alexander R. A. Anderson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Interest in spatial omics is on the rise, but generation of highly multiplexed images remains challenging, due to cost, expertise, methodical constraints, and access to technology. An alternative approach is to register collections of whole
Externí odkaz:
https://doaj.org/article/27aa67cd79b24cdf8baff050f7387c85
Autor:
Magnus J Haughey, Aleix Bassolas, Sandro Sousa, Ann-Marie Baker, Trevor A Graham, Vincenzo Nicosia, Weini Huang
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 3, p e1010952 (2023)
The signature of early cancer dynamics on the spatial arrangement of tumour cells is poorly understood, and yet could encode information about how sub-clones grew within the expanding tumour. Novel methods of quantifying spatial tumour data at the ce
Externí odkaz:
https://doaj.org/article/6ceba31bb6724211bb5d6867bd0e352b
Autor:
Chandler D. Gatenbee, Ann-Marie Baker, Ryan O. Schenck, Maximilian Strobl, Jeffrey West, Margarida P. Neves, Sara Yakub Hasan, Eszter Lakatos, Pierre Martinez, William C. H. Cross, Marnix Jansen, Manuel Rodriguez-Justo, Christopher J. Whelan, Andrea Sottoriva, Simon Leedham, Mark Robertson-Tessi, Trevor A. Graham, Alexander R. A. Anderson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Integration of mathematical modeling, ecological analyses of patient biopsies, and neoantigen heterogeneity suggests recruitment of immunosuppressive cells is key to initializing transformation from adenoma to carcinoma in human colorectal cancer.
Externí odkaz:
https://doaj.org/article/dec007baa85d4e4e91b6bac2af9bca15
Autor:
Fevzi Demircioglu, Jun Wang, Juliana Candido, Ana S. H. Costa, Pedro Casado, Beatriz de Luxan Delgado, Louise E. Reynolds, Jesus Gomez-Escudero, Emma Newport, Vinothini Rajeeve, Ann-Marie Baker, Marina Roy-Luzarraga, Trevor A. Graham, Julie Foster, Yu Wang, James J. Campbell, Rajinder Singh, Penglie Zhang, Thomas J. Schall, Frances R. Balkwill, Jane Sosabowski, Pedro R. Cutillas, Christian Frezza, Patricia Sancho, Kairbaan Hodivala-Dilke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Cancer associated fibroblasts (CAFs) have been suggested to regulate cancer cell metabolism, but the mechanisms are not completely elucidated. Here, the authors show that low FAK expression in stromal cells correlates with poor prognosis in breast an
Externí odkaz:
https://doaj.org/article/514da35f7c834a7f879f285d226a9e53
Autor:
Stephen Bernard, Ann-Marie Baker, Peter Cameron, Mark Fitzgerald, Andrew Forbes, Paul Young, Colin McArthur, Paul S Myles, Russell Gruen, Biswadev Mitra, Russell L Gruen, Dashiell Gantner, Marc Maegele, Lynnette Murray, Tony Trapani, Stephen Rashford, Tony Smith, Michael C Reade, Veronica Pitt, Robert Medcalf, Michael Reade, Huyen Tran, Grant Christey, Zsolt J Balogh, Anthony Trapani, Lynne Murray, Stefan Mazur, Camila Battistuzzo, Andy Swain, Jasmin Board, Nicole S Ng, Sally Hurford
Publikováno v:
BMJ Open, Vol 11, Iss 3 (2021)
Introduction Haemorrhage causes most preventable prehospital trauma deaths and about a third of in-hospital trauma deaths. Tranexamic acid (TXA), administered soon after hospital arrival in certain trauma systems, is an effective therapy in preventin
Externí odkaz:
https://doaj.org/article/f1beea52bfdd43599f1da549613e4e2a
Autor:
Abbie E. Fearon, Edward P. Carter, Natasha S. Clayton, Edmund H. Wilkes, Ann-Marie Baker, Ekaterina Kapitonova, Bakhouche A. Bakhouche, Yasmine Tanner, Jun Wang, Emanuela Gadaleta, Claude Chelala, Kate M. Moore, John F. Marshall, Juliette Chupin, Peter Schmid, J. Louise Jones, Michelle Lockley, Pedro R. Cutillas, Richard P. Grose
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2469-2481 (2018)
Summary: Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to acquisition and maintenan
Externí odkaz:
https://doaj.org/article/7789669635aa4bc0b1737b37a1d0838a
Autor:
Ann-Marie Baker, Weini Huang, Xiao-Ming Mindy Wang, Marnix Jansen, Xiao-Jun Ma, Jeffrey Kim, Courtney M. Anderson, Xingyong Wu, Liuliu Pan, Nan Su, Yuling Luo, Enric Domingo, Timon Heide, Andrea Sottoriva, Annabelle Lewis, Andrew D. Beggs, Nicholas A. Wright, Manuel Rodriguez-Justo, Emily Park, Ian Tomlinson, Trevor A. Graham
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Methods that analyze intra-tumor genetic heterogeneity often do not preserve the spatial context of tumor subclones. Here, the authors present BaseScope, a mutation-specific RNA in situ hybridization assay and spatially map colorectal cancer and aden
Externí odkaz:
https://doaj.org/article/04a8b784261d4d7da0ef04bead32687f
Autor:
Pierre Martinez, Margriet R. Timmer, Chiu T. Lau, Silvia Calpe, Maria del Carmen Sancho-Serra, Danielle Straub, Ann-Marie Baker, Sybren L. Meijer, Fiebo J. W. ten Kate, Rosalie C. Mallant-Hent, Anton H. J. Naber, Arnoud H. A. M. van Oijen, Lubbertus C. Baak, Pieter Scholten, Clarisse J. M. Böhmer, Paul Fockens, Jacques J. G. H. M. Bergman, Carlo C. Maley, Trevor A. Graham, Kausilia K Krishnadath
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Barrett’s oesophagus is thought to be a precursor lesion for oesophageal cancer, and predicting the benign lesions that progress to cancer is clinically important. Here, the authors use FISH to study the clonal evolution of Barrett’s oesophagus a
Externí odkaz:
https://doaj.org/article/30abe593d39a4da4b5f584456b184821
Autor:
Ann-Marie Baker, Biancastella Cereser, Samuel Melton, Alexander G. Fletcher, Manuel Rodriguez-Justo, Paul J. Tadrous, Adam Humphries, George Elia, Stuart A.C. McDonald, Nicholas A. Wright, Benjamin D. Simons, Marnix Jansen, Trevor A. Graham
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 940-947 (2014)
Human intestinal stem cell and crypt dynamics remain poorly characterized because transgenic lineage-tracing methods are impractical in humans. Here, we have circumvented this problem by quantitatively using somatic mtDNA mutations to trace clonal li
Externí odkaz:
https://doaj.org/article/5803d8f2cc1e4ffd817fc85712de1e0b