Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ann‐Christin Nickel"'
Autor:
Renfei Du, Ahmed Y. Sanin, Wenjie Shi, Bing Huang, Ann-Christin Nickel, Andres Vargas-Toscano, Shuran Huo, Thomas Nickl-Jockschat, Claudia A. Dumitru, Wei Hu, Siyu Duan, I. Erol Sandalcioglu, Roland S. Croner, Joshua Alcaniz, Wolfgang Walther, Carsten Berndt, Ulf D. Kahlert
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Glioblastoma (GBM) is the most commonly occurring and most aggressive primary brain tumor. Transcriptomics-based tumor subtype classification has established the mesenchymal lineage of GBM (MES-GBM) as cancers with particular aggressive behavior and
Externí odkaz:
https://doaj.org/article/6f46caeb3c7e4375a3ce00e72c97f3d4
Autor:
N. Z. Mehjardi, J. Kessler, A. Y. Sanin, D. Picard, P. Westhoff, Ann-Christin Nickel, C. Uhlmann, W. Shi, H. J. Steiger, M. Remke, I. Fischer, D. Vordermark, R. S. Croner, U. D. Kahlert
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract The application of patient-derived (PD) in vitro tumor models represents the classical strategy for clinical translational oncology research. Using these cellular heterogeneous cultures for the isolation of cancer stem cells (CSCs), suggeste
Externí odkaz:
https://doaj.org/article/34def6153a8d4e58a52e3b553ff403b8
Autor:
Michael Hewera, Ann-Christin Nickel, Nina Knipprath, Sajjad Muhammad, Xiaolong Fan, Hans-Jakob Steiger, Daniel Hänggi, Ulf Dietrich Kahlert
Publikováno v:
F1000Research, Vol 9 (2020)
Background: Increasing concerns emerge regarding the limited success in reproducing data and translating research results into applications. This is a major problem for science, society and economy. Driven by industry or scientific networks, several
Externí odkaz:
https://doaj.org/article/276bfaea3c8c4df7bb9aaccfdb826354
Autor:
Andres Vargas-Toscano, Dilaware Khan, Ann-Christin Nickel, Michael Hewera, Marcel Alexander Kamp, Igor Fischer, Hans-Jakob Steiger, Wei Zhang, Sajjad Muhammad, Daniel Hänggi, Ulf Dietrich Kahlert
Publikováno v:
CNS Oncology, Vol 9, Iss 2 (2020)
Aim: Glioblastoma is a heterogeneous lethal disease, regulated by a stem-cell hierarchy and the neurotransmitter microenvironment. The identification of chemotherapies targeting individual cancer stem cells is a clinical need. Methodology: A robotic
Externí odkaz:
https://doaj.org/article/32b88ec1ba78406b9585cff02a38557d
Autor:
Michael Hewera, Ann-Christin Nickel, Nina Knipprath, Sajjad Muhammad, Xiaolong Fan, Hans-Jakob Steiger, Daniel Hänggi, Ulf Dietrich Kahlert
Publikováno v:
F1000Research, Vol 9 (2020)
Background: Increasing concerns emerge regarding the limited success in reproducing research results. This is a major problem for science, society and economy. Driven by industry or scientific networks, several attempts to combat this crisis are init
Externí odkaz:
https://doaj.org/article/76e7eb13e6eb433b98ca9bd2f25b9346
Autor:
Dilaware Khan, Ann-Christin Nickel, Sebastian Jeising, Constanze Uhlmann, Sajjad Muhammad, Daniel Hänggi, Igor Fischer, Ulf Dietrich Kahlert
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 919 (2021)
Human induced pluripotent stem cells (hiPSCs) have emerged as a powerful tool for in vitro modelling of diseases with broad application in drug development or toxicology testing. These assays usually require large quantities of hiPSC, which can entai
Externí odkaz:
https://doaj.org/article/78dc7339f6c44edf9b020145692424c1
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 295 (2021)
Gold nanoparticles (Au NPs) are studied as delivery systems to enhance the effect of the glutaminase1 inhibitor CB839, a promising drug candidate already in clinical trials for tumor treatments. Au NPs were synthesized using a bottom-up approach and
Externí odkaz:
https://doaj.org/article/3fb7001fb649418ea8ea82ba9551b9a1
Autor:
Igor Fischer, Ann-Christin Nickel, Nan Qin, Kübra Taban, David Pauck, Hans-Jakob Steiger, Marcel Kamp, Sajjad Muhammad, Daniel Hänggi, Ellen Fritsche, Marc Remke, Ulf Dietrich Kahlert
Publikováno v:
Cells, Vol 9, Iss 12, p 2689 (2020)
In cancer pharmacology, a drug candidate’s therapeutic potential is typically expressed as its ability to suppress cell growth. Different methods in assessing the cell phenotype and calculating the drug effect have been established. However, incons
Externí odkaz:
https://doaj.org/article/9328bc51d21846a9aa4f60178d217372
Autor:
Lorenzo Galluzzi, Ilio Vitale, Laura Senovilla, Ken André Olaussen, Guillaume Pinna, Tobias Eisenberg, Aïcha Goubar, Isabelle Martins, Judith Michels, Gueorgui Kratassiouk, Didac Carmona-Gutierrez, Marie Scoazec, Erika Vacchelli, Frederic Schlemmer, Oliver Kepp, Shensi Shen, Maximilien Tailler, Mireia Niso-Santano, Eugenia Morselli, Alfredo Criollo, Sandy Adjemian, Mohamed Jemaà, Kariman Chaba, Claire Pailleret, Mickaël Michaud, Federico Pietrocola, Nicolas Tajeddine, Thibault de La Motte Rouge, Natalia Araujo, Nadya Morozova, Thomas Robert, Hugues Ripoche, Frederic Commo, Benjamin Besse, Pierre Validire, Pierre Fouret, Angélique Robin, Nicolas Dorvault, Philippe Girard, Sébastien Gouy, Patricia Pautier, Nora Jägemann, Ann-Christin Nickel, Sabrina Marsili, Caroline Paccard, Nicolas Servant, Philippe Hupé, Carmen Behrens, Parviz Behnam-Motlagh, Kimitoshi Kohno, Isabelle Cremer, Diane Damotte, Marco Alifano, Øivind Midttun, Per Magne Ueland, Vladimir Lazar, Philippe Dessen, Hans Zischka, Etienne Chatelut, Maria Castedo, Frank Madeo, Emmanuel Barillot, Juergen Thomale, Ignacio Ivan Wistuba, Catherine Sautès-Fridman, Laurence Zitvogel, Jean-Charles Soria, Annick Harel-Bellan, Guido Kroemer
Publikováno v:
Cell Reports, Vol 2, Iss 2, Pp 257-269 (2012)
Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and i
Externí odkaz:
https://doaj.org/article/c962346fede94134a0ec7d5f7e6f4ffd
Autor:
Serdar Alpdogan, Timo Sander, Rui Zhang, Dilaware Khan, Xuanchen Li, Huakang Zhou, Ke Li, Ann-Christin Nickel, Baolong Zheng, Anastasiya Skryabin, Simon Schieferdecker, Björn B. Hofmann, Daniel Maximilian Donaldson, Jan Frederick Cornelius, Daniel Hänggi, Sajjad Muhammad
Publikováno v:
Translational Stroke Research.
Robust preclinical models are inevitable for researchers to unravel pathomechanisms of subarachnoidal hemorrhage (SAH). For the mouse perforation model of SAH, the goal of this meta-review was the determination of variances in mortality, SAH severity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d0a959da5fe073b0309949645fa9f3
https://doi.org/10.1007/s12975-022-01106-4
https://doi.org/10.1007/s12975-022-01106-4