Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Ann, Doherty"'
Autor:
Noelia Perez-Diaz, Ewelina Hoffman, Julie Clements, Rebecca Cruickshank, Ann Doherty, Daniel Ebner, Joanne Elloway, Jianan Fu, Joanne Kelsall, Val Millar, Ouarda Saib, Andrew Scott, Ian Woods, Victoria Hutter
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Introduction:In vitro approaches are an essential tool in screening for toxicity of new chemicals, products and therapeutics. To increase the reproducibility and human relevance of these in vitro assessments, it is advocated to remove animal-derived
Externí odkaz:
https://doaj.org/article/5f4beb6e9c5a4961acd2c0f174e2524e
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Micronucleus (MN) assessment is a valuable tool in safety assessment. However, several compounds are positive in the in vivo bone marrow (BM) MN assay but negative in vitro, reflecting that BM complexity is not recapitulated in vitro. Import
Externí odkaz:
https://doaj.org/article/a0d2a586f0fc4f4e9d2b85c530eb68b8
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract To provide a comprehensive analysis of small molecule genotoxic potential we have developed and validated an automated, high-content, high throughput, image-based in vitro Micronucleus (IVM) assay. This assay simultaneously assesses micronuc
Externí odkaz:
https://doaj.org/article/734ce7250fa54c68a6acc32cb4966de1
Autor:
Ann Doherty, Frank Moriarty, Fiona Boland, Barbara Clyne, Tom Fahey, Seán Kennelly, Emma Wallace
Publikováno v:
HRB Open Research, Vol 4 (2021)
Introduction: Internationally, health systems face the challenge of managing a growing ageing population living with multimorbidity and polypharmacy. Potentially inappropriate prescribing is common among patients with polypharmacy, increasing the ris
Externí odkaz:
https://doaj.org/article/615bf64382c5403aa7e41f7bb4a8e7f4
Autor:
David Sheppard, Zhiwei Cai, David Lea-Smith, Barbara Stevenson, Ann Doherty, Heather Davidson, David Porteous, A Boyd
Publikováno v:
Physiology. 38
Mouse cystic fibrosis transmembrane conductance regulator (CFTR) differs from human CFTR in several important respects: altered gating pattern distinguished by prolonged residence in a sub-conductance state, reduced single-channel conductance and str
Publikováno v:
Journal of Affective Disorders. 298:345-354
Background This study investigated the role of a large range psychological, attitudinal and health related variables as predictors of depression trajectories amongst older adults over a 4-year time period. Methods Data from three consecutive waves of
Autor:
Gregory Hamm, Gareth Maglennon, Beth Williamson, Ruth Macdonald, Ann Doherty, Stewart Jones, Jayne Harris, James Blades, Alexander R. Harmer, Peter Barton, Philip B. Rawlins, Paul Smith, Jon Winter-Holt, Lindsay McMurray, Julia Johansson, Paul Fitzpatrick, William McCoull, Muireann Coen
Publikováno v:
Archives of Toxicology. 96:613-624
The receptor tyrosine kinase, MERTK, plays an essential role in homeostasis of the retina via efferocytosis of shed outer nuclear segments of photoreceptors. The Royal College of Surgeons rat model of retinal degeneration has been linked to loss-of-f
Autor:
Ann Doherty, Faiza Shahid, Orla Cotter, Frank Moriarty, Barbara Clyne, Fiona Boland, Tobias Dreischulte, Tom Fahey, Sean Kennelly, Emma Wallace
Background: The misattribution of an adverse drug reaction (ADR) as a symptom or illness can lead to the prescribing of additional medication, referred to as a prescribing cascade. The aim of this systematic review is to identify published prescribin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2777521a9ba8cf57a633cce573ca8bb0
https://doi.org/10.22541/au.165598386.60692033/v1
https://doi.org/10.22541/au.165598386.60692033/v1
Publikováno v:
European Journal of Psychological Assessment. 37:6-14
Abstract. Several studies challenge the three-dimensional structure of the Maslach Burnout Inventory – Human Services Survey (MBI-HSS), citing alternative measurement models including bifactor models. While bifactor models have merit, if data sampl
Autor:
Eric WFW Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield, Diana Bilton, Emily V Bloomfield, A Christopher Boyd, June Brand, Ruaridh Buchan, Roberto Calcedo, Paula Carvelli, Mario Chan, Seng H Cheng, David S Collie, Steve Cunningham, Heather E Davidson, Gwyneth Davies, Jane C Davies, Lee A Davies, Maria H Dewar, Ann Doherty, Jackie Donovan, Natalie S Dwyer, Hala I Elgmati, Rosanna F Featherstone, Jemyr Gavino, Sabrina Gea-Sorli, Duncan M Geddes, James SR Gibson, Deborah R Gill, Andrew P Greening, Uta Griesenbach, David M Hansell, Katharine Harman, Tracy E Higgins, Samantha L Hodges, Stephen C Hyde, Laura Hyndman, J Alastair Innes, Joseph Jacob, Nancy Jones, Brian F Keogh, Maria P Limberis, Paul Lloyd-Evans, Alan W Maclean, Michelle C Manvell, Dominique McCormick, Michael McGovern, Gerry McLachlan, Cuixiang Meng, M Angeles Montero, Hazel Milligan, Laura J Moyce, Gordon D Murray, Andrew G Nicholson, Tina Osadolor, Javier Parra-Leiton, David J Porteous, Ian A Pringle, Emma K Punch, Kamila M Pytel, Alexandra L Quittner, Gina Rivellini, Clare J Saunders, Ronald K Scheule, Sarah Sheard, Nicholas J Simmonds, Keith Smith, Stephen N Smith, Najwa Soussi, Samia Soussi, Emma J Spearing, Barbara J Stevenson, Stephanie G Sumner-Jones, Minna Turkkila, Rosa P Ureta, Michael D Waller, Marguerite Y Wasowicz, James M Wilson, Paul Wolstenholme-Hogg, on behalf of the UK Cystic Fibrosis Gene Therapy Consortium
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 3, Iss 5 (2016)
Background: Cystic fibrosis (CF) is a chronic, life-limiting disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene leading to abnormal airway surface ion transport, chronic lung infections, inflammation and eventual re
Externí odkaz:
https://doaj.org/article/09b29fe1b155492fba24a177fe4be24c