Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Anmol Nagpal"'
Publikováno v:
Current Opinion in Genetics & Development. 65:34-41
Control of protein synthesis (mRNA translation) is essential for proper brain development and function. Perturbations to the mechanisms governing mRNA translation have repeatedly been shown to constitute a neurodegenerative, neuropsychiatric, and neu
Autor:
Shane Wiebe, Karim Nader, Argel Aguilar-Valles, Vinh Tai Truong, Ilse Gantois, Seyed Mehdi Jafarnejad, Jean-Claude Lacaille, Clément Chapat, Nahum Sonenberg, Vijendra Sharma, Jelena Popic, Erika Freemantle, Christos G. Gkogkas, Isabelle A. Groves, Anmol Nagpal, Tine Pooters, Agnieszka Skalecka, Karine Gamache, Arkady Khoutorsky, Ruifeng Cao, Elizabeth A. McCullagh
Publikováno v:
Gantois, I, Khoutorsky, A, Popic, J, Aguilar-Valles, A, Freemantle, E, Cao, R, Sharma, V, Pooters, T, Nagpal, A, Skalecka, A, Truong, V T, Wiebe, S, Groves, I A, Jafarnejad, S M, Chapat, C, McCullagh, E A, Gamache, K, Nader, K, Lacaille, J-C, Gkogkas, C G & Sonenberg, N 2017, ' Metformin ameliorates core deficits in a mouse model of fragile X syndrome ', Nature Medicine, vol. 23, pp. 674-677 . https://doi.org/10.1038/nm.4335
Fragile X syndrome (FXS) is the leading monogenic cause of autism spectrum disorders (ASD). Trinucleotide repeat expansions in FMR1 abolish FMRP expression, leading to hyperactivation of ERK and mTOR signaling upstream of mRNA translation. Here we sh
Autor:
Jeehyun Park, Ilse Gantois, Arkady Khoutorsky, Agnieszka Skalecka, Nahum Sonenberg, Alexander J. He, Vinh Tai Truong, Shane Wiebe, Anmol Nagpal, Karine Gamache
Translational control plays a key role in regulation of neuronal activity and behavior. Deletion of the translational repressor 4E-BP2 in mice alters excitatory and inhibitory synaptic functions, engendering autistic-like behaviors. The contribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a159fb9eebca184bde8b08ee4a53e1f7
https://europepmc.org/articles/PMC6731681/
https://europepmc.org/articles/PMC6731681/