Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Anmada Nayak"'
Autor:
Victoria H. Ng, Zachary Spencer, Leif R. Neitzel, Anmada Nayak, Matthew A. Loberg, Chen Shen, Sara N. Kassel, Heather K. Kroh, Zhenyi An, Christin C. Anthony, Jamal M. Bryant, Amanda Lawson, Lily Goldsmith, Hassina Benchabane, Amanda G. Hansen, Jingjing Li, Starina D’Souza, Andres M. Lebensohn, Rajat Rohatgi, William A. Weiss, Vivian L. Weiss, Charles Williams, Charles C. Hong, David J. Robbins, Yashi Ahmed, Ethan Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The relative abundance of Wnt receptors plays a crucial role in controlling Wnt signaling in tissue homeostasis and human disease. While the ubiquitin ligases that ubiquitylate Wnt receptors are well-characterized, the deubiquitylase that re
Externí odkaz:
https://doaj.org/article/ef64ae66e0614f03b079cfeb3260d710
Autor:
Chen Shen, Anmada Nayak, Leif R. Neitzel, Amber A. Adams, Maya Silver-Isenstadt, Leah M. Sawyer, Hassina Benchabane, Huilan Wang, Nawat Bunnag, Bin Li, Daniel T. Wynn, Fan Yang, Marta Garcia-Contreras, Charles H. Williams, Sivanesan Dakshanamurthy, Charles C. Hong, Nagi G. Ayad, Anthony J. Capobianco, Yashi Ahmed, Ethan Lee, David J. Robbins
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Cereblon (CRBN) is an E3 ubiquitin ligase substrate receptor that is involved in cancer cell death, although its regulation is poorly understood. Here, the authors show that Wnt ligand increases CRBN-dependent protein degradation and demonstrate CRBN
Externí odkaz:
https://doaj.org/article/b0213d02bb5e42d487d2f5912805e034
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract To overcome the toxicity, pharmacokinetics and drug resistance associated with doxorubicin (DOX), a strategy was developed by encapsulating DOX- loaded-PLGA-PVA- nanoparticles within chitosan-dextran sulfate nanoparticles (CS-DS) [CS-DS-coat
Externí odkaz:
https://doaj.org/article/3f8a9563eab54721a3be877b8a0a749f
Autor:
Chen Shen, Anmada Nayak, Ricardo A. Melendez, Daniel T. Wynn, Joshua Jackson, Ethan Lee, Yashi Ahmed, David J. Robbins
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5940 (2020)
Wnt signaling regulates numerous cellular processes during embryonic development and adult tissue homeostasis. Underscoring this physiological importance, deregulation of the Wnt signaling pathway is associated with many disease states, including can
Externí odkaz:
https://doaj.org/article/77861b8e5f334138909646bd059bbb72
Autor:
Fan Yang, Jezabel Rodriguez-Blanco, Jun Long, Marzena Swiderska-Syn, Daniel T. Wynn, Bin Li, Chen Shen, Anmada Nayak, Yuguang Ban, Xiaodian Sun, Robert K. Suter, Heather J. McCrea, Anthony J. Capobianco, Nagi G. Ayad, David J. Robbins
Publikováno v:
Mol Cancer Res
Dysregulation of Sonic hedgehog (SHH) signaling drives the growth of distinct cancer subtypes, including medulloblastoma (MB). Such cancers have been treated in the clinic with a number of clinically relevant SHH inhibitors, the majority of which tar
Autor:
David J. Robbins, Nagi G. Ayad, Anthony J. Capobianco, Heather J. McCrea, Robert K. Suter, Xiaodian Sun, Yuguang Ban, Anmada Nayak, Chen Shen, Bin Li, Daniel T. Wynn, Marzena Swiderska-Syn, Jun Long, Jezabel Rodriguez-Blanco, Fan Yang
Supplementary Figure from A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog–Dependent Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10389b39f7c2504b80af45872eabbf86
https://doi.org/10.1158/1541-7786.22527851.v1
https://doi.org/10.1158/1541-7786.22527851.v1
Autor:
Chen Shen, Anmada Nayak, Leif R. Neitzel, Fan Yang, Bin Li, Charles H. Williams, Charles C. Hong, Yashi Ahmed, Ethan Lee, David J. Robbins
Publikováno v:
The Journal of biological chemistry. 298(8)
The Cullin-RING ligase 4 E3 ubiquitin ligase component Cereblon (CRBN) is a well-established target for a class of small molecules termed immunomodulatory drugs (IMiDs). These drugs drive CRBN to modulate the degradation of a number of neosubstrates
Autor:
Christopher S. Cselenyi, Leif R. Neitzel, Anmada Nayak, Hassina Benchabane, David J. Robbins, Yashi Ahmed, James G. Patton, Alya Zouaoui, Victoria H. Ng, Leah Stephens, Chey Anne Q. Youngblood, Ethan Lee, Trevor Hann, Zachary T. Spencer
Publikováno v:
Mechanisms of Development. 156:20-31
In a screen for human kinases that regulate Xenopus laevis embryogenesis, we identified Nagk and other components of the UDP-GlcNAc glycosylation salvage pathway as regulators of anteroposterior patterning and Wnt signaling. We find that the salvage
Autor:
David J. Robbins, Joshua Jackson, Anmada Nayak, Ethan Lee, Ricardo A. Melendez, Daniel Wynn, Chen Shen, Yashi Ahmed
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5940, p 5940 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Wnt signaling regulates numerous cellular processes during embryonic development and adult tissue homeostasis. Underscoring this physiological importance, deregulation of the Wnt signaling pathway is associated with many disease states, including can
Autor:
Fan Yang, Ethan Lee, Marta Garcia-Contreras, Maya Silver-Isenstadt, Huilan Wang, David J. Robbins, Sivanesan Dakshanamurthy, Daniel Wynn, Nagi G. Ayad, Yashi Ahmed, Bin Li, Anmada Nayak, Chen Shen, Leah M. Sawyer, Leif R. Neitzel, Hassina Benchabane, Charles H. Williams, Amber A Adams, Charles C. Hong, Nawat Bunnag, Anthony J. Capobianco
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Immunomodulatory drugs (IMiDs) are important for the treatment of multiple myeloma and myelodysplastic syndrome. Binding of IMiDs to Cereblon (CRBN), the substrate receptor of the CRL4CRBN E3 ubiquitin ligase, induces cancer cell death by targeting k