Supplementary Tables from Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer

Autor: Brahm H. Segal, Emese Zsiros, Michael B. Yaffe, Kunle Odunsi, Kirsten B. Moysich, Kevin H. Eng, James A. Lederer, Sanjay Ram, Steven M. Holland, Jörg Eder, Holger Sellner, Anna Schubart, Viviana P. Ferreira, Lee-Ann H. Allen, Ilse Jongerius, Taco W. Kuijpers, Sora Suzuki, Mieke C. Brouwer, Cathelijn E.M. Aarts, Ivy L. Debreceni, Stephanie L. Silva-Del Toro, Kaitlyn Howard, Jason Ricciuti, ANM Nazmul H. Khan, Kelly L. Singel, Thejaswini Giridharan, Tiffany R. Emmons

Supplementary Tables 1-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a13f6bea6ac0d91539043db8f72237
https://doi.org/10.1158/2326-6066.22543195

Supplementary Data Table S1 from Quantification of Early-Stage Myeloid-Derived Suppressor Cells in Cancer Requires Excluding Basophils

Autor: Brahm H. Segal, Scott I. Abrams, Kunle Odunsi, Kirsten B. Moysich, Kevin H. Eng, Joseph D. Tario, Brandon E. Smith, Jaron Mark, Kelly L. Singel, Emad Alqassim, Jerry T. Wong, Tiffany R. Emmons, ANM Nazmul H. Khan

Anti-human mAb used in flow cytometry analysis and cell sorting for this study.

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https://doi.org/10.1158/2326-6066.22543876

Data from Quantification of Early-Stage Myeloid-Derived Suppressor Cells in Cancer Requires Excluding Basophils

Autor: Brahm H. Segal, Scott I. Abrams, Kunle Odunsi, Kirsten B. Moysich, Kevin H. Eng, Joseph D. Tario, Brandon E. Smith, Jaron Mark, Kelly L. Singel, Emad Alqassim, Jerry T. Wong, Tiffany R. Emmons, ANM Nazmul H. Khan

Myeloid derived suppressor cells (MDSC) are a heterogeneous group of immature cells that accumulate in the peripheral blood and tumor microenvironment and are barriers to cancer therapy. MDSCs serve as prognostic biomarkers and are targets for therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b9e356f13231f058217c5858429e71
https://doi.org/10.1158/2326-6066.c.6550441.v1

Mechanisms driving neutrophil-induced t-cell immunoparalysis in ovarian cancer

Autor: Viviana P. Ferreira, Ilse Jongerius, Kelly L. Singel, Kunle Odunsi, Stephanie L. Silva-Del Toro, Thejaswini Giridharan, Anm Nazmul H. Khan, Jason Ricciuti, Kirsten B. Moysich, Kaitlyn Howard, Emese Zsiros, Kevin H. Eng, Tiffany R. Emmons, Brahm H. Segal, James A. Lederer, Sora Suzuki, Cathelijn E.M. Aarts, Holger Sellner, Taco W. Kuijpers, Mieke C. Brouwer, Steven M. Holland, Joerg Eder, Michael B. Yaffe, Ivy L. Debreceni, Anna Schubart, Sanjay Ram, Lee-Ann H. Allen

Publikováno v: Cancer immunology research, 9(7), 790-810. American Association for Cancer Research Inc.

T-cell activation and expansion in the tumor microenvironment (TME) are critical for antitumor immunity. Neutrophils in the TME acquire a complement-dependent T-cell suppressor phenotype that is characterized by inhibition of T-cell proliferation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec2b3e407c4193b0f84c9e678f3bd26
http://www.scopus.com/inward/record.url?scp=85109040656&partnerID=8YFLogxK

Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells

Autor: Brahm H. Segal, Thejaswini Giridharan, Sora Suzuki, ANM Nazmul H. Khan, Emese Zsiros, Tiffany R. Emmons, Michael B. Yaffe, Angela A. F. Gankema, Mark Hoogeboom, Ines Goetschalckx, Hanke L. Matlung, Taco W. Kuijpers

Publikováno v: Segal, B H, Giridharan, T, Suzuki, S, Khan, A NM N H, Zsiros, E, Emmons, T R, Yaffe, M B, Gankema, A A F, Hoogeboom, M, Goetschalckx, I, Matlung, H L & Kuijpers, T W 2022, ' Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells ', Immunological Reviews . https://doi.org/10.1111/imr.13178

Neutrophils sense microbes and host inflammatory mediators, and traffic to sites of infection where they direct a broad armamentarium of antimicrobial products against pathogens. Neutrophils are also activated by damage-associated molecular patterns

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https://research.vumc.nl/en/publications/d719a9bf-5d75-497d-9dac-c77c7457343a