Zobrazeno 1 - 10
of 404
pro vyhledávání: '"Anlong, Xu"'
Autor:
Xue Liang, Kunpeng Liu, Xin Jia, Cuiqin Cheng, Meiqi Zhang, Lingdong Kong, Qiqi Li, Zhe Liu, Min Li, Junliang Li, Yao Wang, Anlong Xu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 8, Pp 3513-3527 (2024)
Bile acids (BAs) are natural metabolites in mammals and have the potential to function as drugs against viral infection. However, the limited understanding of chenodeoxycholic acid (CDCA) receptors and downstream signaling, along with its lower suppr
Externí odkaz:
https://doaj.org/article/b8181f6001e84516a09bc978280c253e
Publikováno v:
Chinese Medicine, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background Shaoyao Decoction (SYD) is a widely recognized herbal formula utilized in traditional Chinese medicine for the treatment of diarrhea. Although it has demonstrated significant effectiveness in clinical practice for treating ulcerat
Externí odkaz:
https://doaj.org/article/f339dab51698475685e5fa4bf94b3a96
Autor:
Yujiao Huang, Jie Geng, Mengdan Wang, Wenbin Liu, Haikun Hu, Wei Shi, Mei Li, Guiyang Huo, Guangrui Huang, Anlong Xu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Podocytes are specialized terminally differentiated cells in the glomerulus that are the primary target cells in many glomerular diseases. However, the current podocyte cell lines suffer from prolonged in vitro differentiation and limited su
Externí odkaz:
https://doaj.org/article/c024ec4d06e343ed9bf13abf2a98bfcc
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
ObjectiveThis study aims to investigate the pathogenesis of hyperglycemia and its associated vasculopathy using multiomics analyses in diabetes and impaired glucose tolerance, and validate the mechanism using the cell experiments.MethodsIn this study
Externí odkaz:
https://doaj.org/article/0a19308f360e4bf5bed083fb3c7c6fff
Autor:
Kunyu Li, Leiming You, Jianhua Zhen, Guangrui Huang, Ting Wang, Yanan Cai, Yunan Zhang, Anlong Xu
Publikováno v:
Journal of Traditional Chinese Medical Sciences, Vol 11, Iss 1, Pp 3-20 (2024)
Objective: To investigate the molecular mechanism and identify potential drugs for subthreshold depression (SD), and elucidate the detalied mechanism of Danzhi Xiaoyao powder (DZXY) in SD. Methods: Using RNA-sequencing, we identified differentially e
Externí odkaz:
https://doaj.org/article/c107ab3690d241969f90ec26fc1ce4ae
Autor:
Jinyong Wang, Fang Xie, Xin Jia, Xuejiao Wang, Lingdong Kong, Yiying Li, Xue Liang, Meiqi Zhang, Yuting He, Wandi Feng, Tong Luo, Yao Wang, Anlong Xu
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 14, Iss 6, Pp 100972- (2024)
The stimulator of interferon genes (STING), an integral adaptor protein in the DNA-sensing pathway, plays a pivotal role in the innate immune response against infections. Additionally, it presents a valuable therapeutic target for infectious diseases
Externí odkaz:
https://doaj.org/article/5e69b58b7f6a4f7bab4ebf696321d452
Autor:
Jingyi, Li, Lin, Wang, Yuan, Chen, Lingling, Zhang, Qianqian, Jiang, Anlong, Xu, Yansong, Gao
Publikováno v:
In Life Sciences 1 January 2024 336
Autor:
Yong Ge, Jingrong Huang, Rong Chen, Yonggui Fu, Tao Ling, Xin Ou, Xiaohui Rong, Youxiang Cheng, Yi Lin, Fengyi Zhou, Chuanjian Lu, Shaochun Yuan, Anlong Xu
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1012061 (2024)
Alternative polyadenylation (APA) is a widespread mechanism of gene regulation that generates mRNA isoforms with alternative 3' untranslated regions (3' UTRs). Our previous study has revealed the global 3' UTR shortening of host mRNAs through APA upo
Externí odkaz:
https://doaj.org/article/df53266812ce4c1283125db27f9747ab
Publikováno v:
Chinese Medicine, Vol 18, Iss 1, Pp 1-24 (2023)
Abstract Background In recent decades, the prevalence of metabolic diseases, particularly diabetes, hyperlipidemia, obesity, and non-alcoholic fatty liver disease (NAFLD), has increased dramatically, causing great public health and economic burdens w
Externí odkaz:
https://doaj.org/article/426d3d223e4848cfa09554d384f8c56e
Autor:
Susu Liu, Runze Wu, Liutao Chen, Ke Deng, Xin Ou, Xin Lu, Mengxia Li, Chao Liu, Shangwu Chen, Yonggui Fu, Anlong Xu
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113197- (2023)
Summary: Cancer cells usually exhibit shortened 3′ untranslated regions (UTRs) due to alternative polyadenylation (APA) to promote cell proliferation and migration. Upregulated CPSF6 leads to a systematic prolongation of 3′ UTRs, but CPSF6 expres
Externí odkaz:
https://doaj.org/article/371b89ec83054a50913e2e95caa93874