Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ankush Argade"'
Autor:
Alexander B. Rossi, Hui Li, Donald G. Payan, Jeffrey Clough, Ankush Argade, Somasekhar Bhamidipati, Esteban Masuda, Rajinder Singh, Christina Coquilla, Holger Keim, Catherine Sylvain, Sarkiz D. Issakani, David Carroll
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(10)
Here we report the optimization of small molecule inhibitors of human mast cell degranulation via anti-IgE-mediated tryptase release following cross-linking and activation of IgE-loaded FceR1 receptors. The compounds are selective upstream inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484ae22a769e3f3799c8f65e82e22633
https://pubmed.ncbi.nlm.nih.gov/25872982
https://pubmed.ncbi.nlm.nih.gov/25872982
Autor:
Somasekhar Bhamidipati, Sarkiz D. Issakani, David Carroll, Donald G. Payan, Vanessa Taylor, Catherine Sylvain, Holger Keim, Rajinder Singh, Hui Li, Jeffrey Clough, Ellen Herlaar, Brian Wong, Sylvia Braselmann, Esteban Masuda, Ankush Argade, Haoran Zhao
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(10)
Using cultured human mast cells (CHMC) the optimization of 2,4-diaminopyrimidine compounds leading to 22, R406 is described. Compound 22 is a potent upstream inhibitor of mast cell degranulation and its mechanism of action is via inhibition of Syk ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5931dfcb85d77bceba1ed91b4e05a12a
https://pubmed.ncbi.nlm.nih.gov/25891105
https://pubmed.ncbi.nlm.nih.gov/25891105
Autor:
Stacey Huynh, Roy Frances, Vanessa Taylor, Alexander B. Rossi, Ellen Herlaar, Ankush Argade, Esteban Masuda, Donald G. Payan, Sylvia Braselmann, Rajinder Singh, Sarkiz D. Issakani
Publikováno v:
Journal of Allergy and Clinical Immunology. 118:749-755
Background Activation of the IgE receptor, FcɛRI, in mast cells is the key mechanism initiating and propagating pathophysiological responses in allergic rhinitis. Objective Identify and characterize a small molecule inhibitor of IgE-dependent mast c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa654095ad3ab073dd3b0df2b049ee94
https://doi.org/10.1016/j.jaci.2006.05.023
https://doi.org/10.1016/j.jaci.2006.05.023
Autor:
Stipo Jurcevic, Ellen Herlaar, Brian R Wong, Vanessa Taylor, Ankush Argade, Scott Lovell, Thomas Sun, Su Wang, Gary Park, Kunbin Qu, Esteban Masuda, Haoran Zhao, Muhammad Baluom, Angela Lau, Chi Young, Donald G. Payan, Rajinder Singh, Elliott B. Grossbard, Catherine Sylvain, Polly Pine, Sylvia Braselmann
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 319(3)
Recent compelling evidence has lead to renewed interest in the role of antibodies and immune complexes in the pathogenesis of several autoimmune disorders, such as rheumatoid arthritis. These immune complexes, consisting of autoantibodies to self-ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b0eb6e44efcb8d1fa8aaa523574abe
https://pubmed.ncbi.nlm.nih.gov/16946104
https://pubmed.ncbi.nlm.nih.gov/16946104