Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ankur Sheel"'
Autor:
Ashish Manne, Ashwini Esnakula, Ankur Sheel, Amir Sara, Upender Manne, Ravi Kumar Paluri, Kai He, Wancai Yang, Davendra Sohal, Anup Kasi, Anne M. Noonan, Arjun Mittra, John Hays, Sameek Roychowdhury, Pannaga Malalur, Shafia Rahman, Ning Jin, Jordan M. Cloyd, Susan Tsai, Aslam Ejaz, Kenneth Pitter, Eric Miller, Kannan Thanikachalam, Mary Dillhoff, Lianbo Yu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 9041 (2024)
Neoadjuvant therapy (NAT) for early-stage pancreatic ductal adenocarcinoma (PDA) has recently gained prominence. We investigated the clinical significance of mucin 5 AC (MUC5AC), which exists in two major glycoforms, a less-glycosylated immature isof
Externí odkaz:
https://doaj.org/article/b1fab2da00824cabbddfa7f1e921ad46
Autor:
Ankur Sheel, Junu Bae, Ashlee Asada, Gregory A. Otterson, Ragavendra R. Baliga, Kristin L. Koenig
Publikováno v:
Cardio-Oncology, Vol 9, Iss 1, Pp 1-6 (2023)
Abstract Background Hypomethylating agents (HMAs) have shown efficacy in the treatment of hematological malignancies and are indicated for the treatment of chronic myelomonocytic leukemia (CMML). While the HMA decitabine, in its intravenous formulati
Externí odkaz:
https://doaj.org/article/8ad7f046ca434399a6659ce354285d41
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14231 (2023)
Revamping the current biomarker landscape of hepatocellular carcinoma (HCC) with cell-free DNA (cfDNA) could improve overall outcomes. The use of commercially available cfDNA testing (also known as liquid biopsy) is limited by the low prevalence of t
Externí odkaz:
https://doaj.org/article/6e175a830d184c0ba14b5c913817fe1b
Publikováno v:
Cancers, Vol 15, Iss 2, p 433 (2023)
Biliary tract cancers (BTC) arise from biliary epithelium and include cholangiocarcinomas or CCA (including intrahepatic (ICC) and extrahepatic (ECC)) and gallbladder cancers (GBC). They often have poor outcomes owing to limited treatment options, ad
Externí odkaz:
https://doaj.org/article/4c2a59d546cd4203b44ab65de0c3d4e6
Autor:
Haiwei Mou, Deniz M. Ozata, Jordan L. Smith, Ankur Sheel, Suet-Yan Kwan, Soren Hough, Alper Kucukural, Zachary Kennedy, Yueying Cao, Wen Xue
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-11 (2019)
Abstract CRISPR/Cas9 has revolutionized cancer mouse models. Although loss-of-function genetics by CRISPR/Cas9 is well-established, generating gain-of-function alleles in somatic cancer models is still challenging because of the low efficiency of gen
Externí odkaz:
https://doaj.org/article/578de3f1d83f4486ba462701b06c2cc8
Publikováno v:
Cancers, Vol 14, Iss 14, p 3453 (2022)
Cell-free DNA (cfDNA) testing currently does not have a significant role in PDA management: it is insufficient to diagnose PDA, and its use is primarily restricted to identifying targetable mutations (if tissue is insufficient or unavailable). cfDNA
Externí odkaz:
https://doaj.org/article/b4584ff8033e437fa9c47afc42507e1f
Autor:
Ankur Sheel, Rong Shao, Christine Brown, Joanne Johnson, Alexandra Hamilton, Danhui Sun, Julia Oppenheimer, Wendy Smith, Pablo E. Visconti, Michele Markstein, Carol Bigelow, Lawrence M. Schwartz
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The term programmed cell death (PCD) was coined in 1965 to describe the loss of the intersegmental muscles (ISMs) of moths at the end of metamorphosis. While it was subsequently demonstrated that this hormonally controlled death requires de novo gene
Externí odkaz:
https://doaj.org/article/6e20a39a5446453c84dd0260f7e8f79a
Autor:
Haiwei Mou, Jordan L. Smith, Lingtao Peng, Hao Yin, Jill Moore, Xiao-Ou Zhang, Chun-Qing Song, Ankur Sheel, Qiongqiong Wu, Deniz M. Ozata, Yingxiang Li, Daniel G. Anderson, Charles P. Emerson, Erik J. Sontheimer, Melissa J. Moore, Zhiping Weng, Wen Xue
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-8 (2017)
Abstract CRISPR is widely used to disrupt gene function by inducing small insertions and deletions. Here, we show that some single-guide RNAs (sgRNAs) can induce exon skipping or large genomic deletions that delete exons. For example, CRISPR-mediated
Externí odkaz:
https://doaj.org/article/eb5d5328d15c438ebd69f1e862c787e0
Autor:
Kristine M. Cornejo, Jennifer Yates, Taylor Harris, Lukas Bubendorf, Lloyd Hutchinson, Yang Zong, Andrew H. Fischer, Ankur Sheel
Publikováno v:
Journal of the American Society of Cytopathology. 10:94-102
Introduction Cytology and cystoscopy are used to detect urothelial carcinoma (UC), but together they still fail to detect some UC cases and are not suitable for screening asymptomatic individuals. Mutations are present in more than 98% of UC, mutatio
Autor:
Tingting Jiang, Xiao-Ou Zhang, Zhiping Weng, Haiwei Mou, Yueying Cao, Hien Dang, Ankur Sheel, Hao Yin, Chun-Qing Song, Suet-Yan Kwan, Deniz M. Ozata, Xin Wei Wang, Wen Xue
Publikováno v:
Hepatology
Hepatocellular carcinoma (HCC) is an aggressive subtype of liver cancer with few effective treatments, and the underlying mechanisms that drive HCC pathogenesis remain poorly characterized. Identifying genes and pathways essential for HCC cell growth