Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ankur Kapur"'
Autor:
Abhay Misra, David Yowe, Shari L. Caplan, Min Chen, Avirup Bose, Xiaoling Ke, Darrell Panza, Jeffrey Shapiro, Jian Xu, Xiaoping Wu, John L. Diener, Valerie Beaulieu, Waan-Jeng Huang, Ankur Kapur, Jiaping Gao, Sarah F. Mowbray
Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family of proteins. The biological activity of FGF21 was first shown to induce insulin independent glucose uptake in adipocytes through the GLUT1 transporter. Subse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd23ca1535baa3ce1d593834728c7b6
https://doi.org/10.1101/2021.01.04.425295
https://doi.org/10.1101/2021.01.04.425295
Autor:
Patricia H. Reggio, Megan Trznadel, Ankur Kapur, Alexandros Makriyannis, Jahan Marcu, Derek M. Shore, Mary E. Abood
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 345:189-197
Activation of the cannabinoid CB1 receptor (CB1) is modulated by aspartate residue D2.63(176) in transmembrane helix (TMH) 2. Interestingly, D2.63 does not affect the affinity for ligand binding at the CB1 receptor. Studies in class A G protein-coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f8a542f4c3bc9dea2e7e1a05307dff
https://doi.org/10.1124/jpet.112.201046
https://doi.org/10.1124/jpet.112.201046
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 325:341-348
Amino acid residues in the transmembrane domains of the CB(1) receptor are important for ligand recognition and signal transduction. We used site-directed mutagenesis to identify the role of two novel and adjacent residues in the transmembrane helix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2e98de974dc95ab12c4d1d93c3702d
https://doi.org/10.1124/jpet.107.133256
https://doi.org/10.1124/jpet.107.133256
Autor:
Alexandros Makriyannis, Mary E. Abood, Dow P. Hurst, Patricia H. Reggio, Daniel Fleischer, Rob Whitnell, Ganesh A. Thakur, Ankur Kapur
Publikováno v:
Molecular Pharmacology. 71:1512-1524
Ligands of structurally diverse natures are able to bind at the CB 1 cannabinoid receptor, suggesting the existence of multiple binding sites on the receptor. Modeling studies have implicated Ser2.60(173) and Ser7.39(383) as possible interaction site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e36d434b85990acd117a3d71f0acda
https://doi.org/10.1124/mol.107.034645
https://doi.org/10.1124/mol.107.034645
Autor:
Ankur Kapur, Haleli Sharir, Linda M. Console-Bram, Christina Mundy, Steven N. Popoff, Mary E. Abood
The role of cannabinoid receptors in inflammation has been the topic of many research endeavors. Despite this effort, to date the involvement of the endocannabinoid system (ECS) in inflammation remains obscure. The ambiguity of cannabinoid involvemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc7a629e8aa79488afa0619e9f49686
https://europepmc.org/articles/PMC3669693/
https://europepmc.org/articles/PMC3669693/
Autor:
Susanne Heynen-Genel, Mary E. Abood, Wei Chen, Yushi Bai, Thomas D.Y. Chung, Haleli Sharir, Patricia H. Reggio, Pingwei Zhao, Ellen B. Geller, Larry S. Barak, Herbert H. Seltzman, Martin W. Adler, Marc G. Caron, Michelle Sauer, Ankur Kapur, Alan Cowan
Known agonists of the orphan receptor GPR35 are kynurenic acid, zaprinast, 5-nitro-2-(3-phenylproplyamino) benzoic acid, and lysophosphatidic acids. Their relatively low affinities for GPR35 and prominent off-target effects at other pathways, however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded4c9e6dbb1c5bfe4e1f2c4e11aa5d4
https://europepmc.org/articles/PMC2981393/
https://europepmc.org/articles/PMC2981393/
Autor:
Marc G. Caron, Yushi Bai, Haleli Sharir, Pingwei Zhao, Ankur Kapur, Larry S. Barak, Mary E. Abood
Publikováno v:
The Journal of biological chemistry. 284(43)
The cannabinoid receptor 1 (CB(1)) and CB(2) cannabinoid receptors, associated with drugs of abuse, may provide a means to treat pain, mood, and addiction disorders affecting widespread segments of society. Whether the orphan G-protein coupled recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4dbc4ecfa418c5ea91427a509d060c
https://pubmed.ncbi.nlm.nih.gov/19723626
https://pubmed.ncbi.nlm.nih.gov/19723626
Autor:
Diane L. Lynch, Patricia H. Reggio, Dow P. Hurst, Shanping Shi, Steven Hyatt, Deborah L. Lewis, Mary E. Abood, Herbert H. Seltzman, Uju Umejiego, Ankur Kapur, Sean D. McAllister, Michael Roche, Jannie Jones, Daniel Fleischer
Publikováno v:
Journal of medicinal chemistry. 49(20)
The biarylpyrazole, N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716; 1) has been shown to act as an inverse agonist/antagonist at the cannabinoid CB1 receptor. Our previous mutant cycle study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67334433dc9e30b098e5ed0c9e65ab30
https://pubmed.ncbi.nlm.nih.gov/17004712
https://pubmed.ncbi.nlm.nih.gov/17004712
Publikováno v:
Biochemistry. 45(34)
Suberyldicholine, a bisquaternary compound, is a potent nicotinic acetylcholine receptor agonist. Previously, we suggested that at least some of the unusual binding properties of this ligand may be a consequence of its ability to cross-link two bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575fcf1ba097a91db1af8bd79ad4ce8f
https://pubmed.ncbi.nlm.nih.gov/16922509
https://pubmed.ncbi.nlm.nih.gov/16922509