Výsledky vyhledávání - "Ankur K. Shah"

Developing a Phosphospecific IHC Assay as a Predictive Biomarker for Topoisomerase I Inhibitors

Autor: Koji Ando, Yevgeniya Harrington, Ajit Bharti, Mohan Brahmandam, Ankur K. Shah, Julian Taylor-Parker, Yara Hamade Tohme, Adithi Srinivasiah, Eiji Oki

Publikováno v: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 66(8)

Phosphorylation is the most extensively studied posttranslational modification of proteins. There are approximately 500 kinases known in the human genome. The kinase-activated pathways regulate almost every aspect of cell function and a deregulated k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e10b5f32aba5f944d19c13846659726
https://pubmed.ncbi.nlm.nih.gov/29587004

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Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway

Autor: Julian Taylor-Parker, Jeffrey D. Parvin, Al Ozonoff, Forest M. White, Ajit Bharti, Vibhu Sachdev, J. Keith Joung, Ravi Salgia, Koji Ando, Ankur K. Shah, Moira M. Welch, Yiheng Hu, Benjamin P. Kleinstiver, Lucia E. Rameh

Publikováno v: Oncotarget
Impact Journals

Proteasomal degradation of topoisomerase I (topoI) is one of the most remarkable cellular phenomena observed in response to camptothecin (CPT). Importantly, the rate of topoI degradation is linked to CPT resistance. Formation of the topoI-DNA-CPT cle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2107d094ce59c25b35f5ee105be6b6
https://pubmed.ncbi.nlm.nih.gov/28415827

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IHC-based predictive biomarker for irinotecan response

Autor: Ankur K. Shah, Eiji Oki, Ajit Bharti, Vibhu Sachdeva, Julian Taylor-Parker, Koji Ando

Publikováno v: Journal of Clinical Oncology. 34:548-548

548 Background: For gastro-intestinal cancers, irinotecan is used as first or second line, either as single agent or in combination therapy. The patient response rate is low and drug resistance mechanism is not understood. Irinotecan like other topoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4dbb86eda0033867c74873d7f8bd026
https://doi.org/10.1200/jco.2016.34.4_suppl.548

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DIFFERENTIAL SERUM LEVEL OF SPECIFIC HAPTOGLOBIN ISOFORMS IN SMALL CELL LUNG CANCER

Autor: Singh H, Yotsukura S, Ankur K. Shah, Sachdev, Ravi Salgia, Ajit Bharti, Lee J

Lung cancer is the leading cause of cancer death for both men and women in the United States, and similar trends are seen world wide. The lack of early diagnosis is one of the primary reasons for the high mortality rate. A number of biomarkers have b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1940f15a96c655acdf32efef552d1273
https://europepmc.org/articles/PMC2880513/

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Recovery of trifluoroacetic acid from dilute aqueous solutions by reactive distillation

Autor: Ankur K. Shah, Sanjay M. Mahajani, Yogesh S. Mahajan, Ravindra S. Kamath, Nandkumar B. Salve

Publikováno v: IndraStra Global.

It is difficult to recover trifluoroacetic acid (TFA) from its dilute aqueous solutions by conventional techniques. This work investigates the feasibility of using reactive distillation to recover TFA through esterification with 2-propanol. A kinetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810046e3f92349cb2954a52d2a4222b4
http://hdl.handle.net/10054/697

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Abstract 4653: DNA-PKcs dependent phosphorylation of topoI-S10 determines its ubiquitination by BRCA1/BARD1, rate of topoI degradation and CPT response

Autor: Jeffrey D. Parvin, Julian Taylor Parker, Ajit Bharti, Vibhu Sachdev, Yiheng Hu, Yara Hamade Tohme, Ankur K. Shah, Yevnegyia Malinkovich

Publikováno v: Cancer Research. 73:4653-4653

Abstract: The age-adjusted mortality rate for cancer is about the same in the 21st century as it was 50 years ago. In the past decade, our understanding of oncogenesis at molecular level has increased greatly. This has resulted in the development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3112354e5965088ad95ce1195d51382d
https://doi.org/10.1158/1538-7445.am2013-4653

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Effect of DNA-PK dependent phosphorylation of topo-I-S10 on its rate of proteasomal degradation and CPT response

Autor: Ben Tran, Peter Gibbs, Yevgeniya Malinkovich, Umit Tapan, Julian Taylor-Parker, Ajit Bharti, Jeffrey D. Parvin, Forest M. White, Ravi Salgia, Ankur K. Shah, Yara Hamade Tohme, Vibhu Sachdew

Publikováno v: Journal of Clinical Oncology. 33:606-606

606 Background: Topoisomerase I (topo-I) degradation by ubiquitin proteasomal pathway (UPP), in response to camptothecins (CPTs) is linked to the CPT response. But the mechanism is not understood. Methods: Improvised GST pull down experiments were pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39db27f5be79c9c63651dea90bd2387c
https://doi.org/10.1200/jco.2015.33.3_suppl.606

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