Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities

Autor: Yang You, Solaiappan Manimaran, W. Evan Johnson, Oleg Butovsky, Srinidhi Venkatesan Kalavai, Ankita Desani, Alicia A. Van Enoo, Charlotte Madore, Jean-Christophe Delpech, Jennifer I. Luebke, Tsuneya Ikezu, Pin-Hao Chao, Hana Yeh, Asuka Yoshii-Kitahara, Seiko Ikezu, Mina B. Botros, Zhi Ruan, Sudhir Sivakumaran, Maria Medalla, Teresa Guillamon-Vivancos, Maya E. Woodbury, Carl Holland

Publikováno v: Molecular psychiatry
Molecular Psychiatry
Molecular Psychiatry, Nature Publishing Group, 2020, ⟨10.1038/s41380-020-0671-2⟩

Maternal immune activation (MIA) disrupts the central innate immune system during a critical neurodevelopmental period. Microglia are primary innate immune cells in the brain although their direct influence on the MIA phenotype is largely unknown. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f00a9d6703062c80fade6a9d0152ed9
http://europepmc.org/articles/PMC7431382